CYP3A5

gene

HGNC:2638 · 26 retained evidence mentions

Source-grounded findings

Supporting evidence

Type	Entity	Source evidence	Confidence	Extractor
gene	CYP3A5	“CYP3A4 and CYP3A5 polymorphisms greatly impacted the pharmacokinetics of rivaroxaban; CYP2J2 polymorphisms were not greatly associated with the clinical outcome.”	0.98	hgnc_dict_v1
gene	CYP3A5	“Regarding findings from individual studies and single gene-drug pairs, CYP2C19 loss-of-function alleles were strongly associated with clopidogrel non-response in the primary study on this topic (odds ratio: 3.43), and the CYP3A5 genotype was identified as a critical determinant of tacrolimus trough levels with a large effect size (Hedges' g = 1.59).”	0.98	hgnc_dict_v1
gene	CYP3A5	“Key predictive variables included CYP3A5 genotype, hematocrit levels, post-operative days, and weight; however, the significance of genomic features seemed to diminish progressively as therapeutic drug monitoring calibrates dosing in the months following post-transplant.”	0.98	hgnc_dict_v1
gene	CYP3A5	“Impact of CYP3A4 and CYP3A5 polymorphisms on tacrolimus dose requirements in Saudi kidney transplant patients.”	0.98	hgnc_dict_v1
gene	CYP3A5	“CYP3A4 and CYP3A5 Genes in Cyclophosphamide-treated Chronic Lymphocytic Leukemia Patients: A Pharmacogenetics Study.”	0.98	hgnc_dict_v1
gene	CYP3A5	“The Axiom PharmacoFocus Array technique was employed to generate accurate star allele-predicted phenotypes of 3 PK genes (CYP3A4, CYP3A5, and CYP2D6).”	0.98	hgnc_dict_v1
gene	CYP3A5	“Expression of CYP3A7 - in contrast to the related adult hepatic CYP3A4 and CYP3A5 forms - was confirmed in u-HepaRG cells.”	0.98	hgnc_dict_v1
gene	CYP3A5	“Rivaroxaban is also metabolized by the CYP3A5 gene.”	0.98	hgnc_dict_v1
gene	CYP3A5	“CYP3A5 Polymorphisms Leading to Tacrolimus Toxicity Following an Adult Renal Transplant.”	0.98	hgnc_dict_v1
gene	CYP3A5	“The impact of CYP3A4 and CYP3A5 genetic variations on tacrolimus treatment of living-donor Egyptian kidney transplanted patients.”	0.98	hgnc_dict_v1
gene	CYP3A5	“Tacrolimus pharmacokinetics are influenced by CYP3A5, age, and concomitant fluconazole in pediatric kidney transplant patients.”	0.98	hgnc_dict_v1
gene	CYP3A5	“We mined next generation sequencing (NGS) data from 11,889 unrelated Saudi nationals, to determine the presence and frequencies of known functional SNP variants in 8 clinically relevant pharmacogenes (CYP2C9, CYP2C19, CYP3A5, CYP4F2, VKORC1, DPYD, TPMT and NUDT15), recommended by the Clinical Pharmacogenetics Implementation Consortium (CPIC), and collectively identified 82 such star alleles.”	0.98	hgnc_dict_v1
gene	CYP3A5	“This study aimed to investigate the association of CYP3A422 (rs35599367), CYP3A53 (rs776746) single nucleotide polymorphism (SNP) with response to simvastatin in hypercholesterolemia patients conducted at King Abdulaziz University hospital (KAUH) in Jeddah, Saudi Arabia.”	0.98	hgnc_dict_v1
gene	CYP3A5	“Ticagrelor's primary active metabolite, ARC124910XX (ARC), is formed via the most abundant hepatic cytochrome P450 (CYP) enzyme, CYP3A4, and CYP3A5.”	0.98	hgnc_dict_v1
gene	CYP3A5	“Genotyping for CYP2B6, CYP2A6, CYP3A5, ABCB1, NR1I2, and NR1I3 single nucleotide polymorphism (SNPs) was performed by TaqMan® allelic discrimination method.”	0.98	hgnc_dict_v1
gene	CYP3A5	“The CYP3A5 genotypes of both liver transplant recipients and donors influence the time-dependent recovery of tacrolimus clearance during the early stage following transplantation.”	0.98	hgnc_dict_v1
gene	CYP3A5	“Genetic polymorphisms of CYP3A5, CHRM2, and ZNF498 and their association with epilepsy susceptibility: a pharmacogenetic and case-control study.”	0.98	hgnc_dict_v1
gene	CYP3A5	“Investigating the Effect of Demographics, Clinical Characteristics, and Polymorphism of MDR-1, CYP1A2, CYP3A4, and CYP3A5 on Clopidogrel Resistance.”	0.98	hgnc_dict_v1
gene	CYP3A5	“Ibrahim P46 Genetic divergence of CYP3A5*3 pharmacogenomic marker for native and admixed Mexican populations J.”	0.98	hgnc_dict_v1
gene	CYP3A5	“These data also reflect on the differences observed in the prevalence of high-risk genotypes in these populations, as far as common markers in the CYP2C9, CYP2C19, CYP3A5, VKORC1, SLCO1B1 and TPMT pharmacogenes are concerned.”	0.98	hgnc_dict_v1
gene	CYP3A5	“Quantitation of the impact of CYP3A5 A6986G polymorphism on quetiapine pharmacokinetics by simulation of target attainment.”	0.98	hgnc_dict_v1
gene	CYP3A5	“Recent pharmacogenetic studies involving various transplant recipients in diverse ethnic populations revealed contradictory findings regarding the impact of CYP3A5 and multidrug resistance-1 (MDR1) single nucleotide polymorphisms (SNPs) on the pharmacodynamics of tacrolmius (TAC).”	0.98	hgnc_dict_v1
gene	CYP3A5	“The impact of CYP3A5 and MDR1 polymorphisms on tacrolimus dosage requirements and trough concentrations in pediatric renal transplant recipients.”	0.98	hgnc_dict_v1
gene	CYP3A5	“Influence of CYP3A5 6986A > G and ABCB1 3435C > T Polymorphisms on Adverse Events Associated With Tacrolimus in Jordanian Pediatric Renal Transplant Patients.”	0.98	hgnc_dict_v1
gene	CYP3A5	“Genotyping of cytochrome P450 enzymes CYP2B6, CYP2C9, CYP2C19, CYP3A5, aldehyde dehydrogenase (ALDH3A1), and glutathione S-transferase (GSTA1) was done either through RFLP or pyrosequencing.”	0.98	hgnc_dict_v1
gene	CYP3A5	“Interestingly, fetal livers that expressed CYP3A7.2 also expressed CYP3A5 protein, and we found a linkage disequilibrium between the CUpsilonP3A72 and CUpsilonP3A51 alleles that was subject to interethnic differences.”	0.98	hgnc_dict_v1