APOE
HGNC:613 · 41 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | APOE | “These patients previously tested negative for mutations in genes known to cause AD and were genotyped for APOE alleles.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Second, adult-onset glaucoma follows a distinct polygenic architecture where APOE ε2 confers a near five-fold risk for primary angle-closure glaucoma (OR = 4.82), an effect absent or inconsistent in global datasets, and NOS3 variants associate with primary open-angle glaucoma specifically in men, a sex-stratified signal unreported outside Saudi cohorts.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Apolipoprotein E in Alzheimer's disease: A review of APOE receptors, signalling pathways and therapeutic opportunities.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “The most consistent evidence was observed for CETP, APOE, and APOB, particularly in relation to broader macronutrient composition and fat-related exposures, while ABCA1 and APOA5 showed significant but more limited evidence.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “The etiology and progression of these disorders are influenced by a complex interplay of environmental factors and genetic predispositions with specific genetic markers, such as mutations in the APOE and HTT genes, which play pivotal roles.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Then, protein-protein interaction (PPI) network analysis pinpointed seven top-ranked DEGs (GAPDH, PTEN, CCND1, APOE, ESR1, MAPK3/ERK1, and SNCA) as KGs or central modulators of PD pathogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “While the study is limited by the absence of external validation and genetic variables (e.g., APOE), it establishes a reproducible, interpretable, and computationally efficient ML framework for AQI forecasting.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “This article investigates the intricate associations between apolipoprotein E (APOE) gene alleles variation, insulin resistance (IR) and amyloid-β aggregation in cardiovascular disease (CVD) patients.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Relationships Between APOE, Type 2 Diabetes, and Cardiovascular Disease in Postmenopausal Women.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Correlation of APOE polymorphism, expression, and plasma levels with cardiac comorbidities among lipodystrophy in HIV-infected patients.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “APOE, BIN1, SORL1, ADAM10, APH1B, and SPI1 have been identified by previous AD GWAS.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Key genetic markers, such as the APOE ε4 allele in AD and the CYP2D6 polymorphisms in PD, are highlighted for their roles in modulating drug efficacy.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Genetic polymorphisms in TREM2, APOE, and CD33 highlight the significant impact of microglial dysfunction in AD.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Background: Apolipoprotein E (APOE) gene polymorphism has been implicated in the pathogenesis of various metabolic disorders, including type 2 diabetes mellitus (T2DM).” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Being age-related disorders, both Alzheimer's disease (AD) and stroke share multiple risk factors, such as hypertension, smoking, diabetes, and apolipoprotein E (APOE) Ɛ4 genotype, and coexist in patients.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “We performed genetic testing for APOE, MAPT, PSEN1, PSEN2 and APP.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “APOE ε2-Carriers Are Associated with an Increased Risk of Primary Angle-Closure Glaucoma in Patients of Saudi Origin.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Common Variants rs429358 and rs7412 in APOE Gene Are Not Associated with POAG in a Saudi Cohort.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “In addition, polymorphisms in the apolipoprotein E (APOE) gene, namely, rs429358 and rs7412, responsible for APOE allelic variants ε2, ε3, and ε4, may influence KC via oxidative stress mechanism(s).” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “We identified an association between dyslipidemia and variants identified in genes such as JCAD, GLIS3, CD38, FN1, CELSR2, MTNR1B, GIPR, DYM, APOB, APOE, ADCY5.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Association of CELSR2, APOB100, ABCG5/8, LDLR, and APOE polymorphisms and their genetic risks with lipids among the Thai subjects.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Exercise modulates APOE expression in brain cortex of female APOE3 and APOE4 targeted replacement mice.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Thirteen genetic variants, including FV G1691A, FV A4070G, F2 G20210A, F13A1 G103T, FGB - 455G > A, PAI-1 - 675 4G/5G, ITGB3 T1565C, MTHFR C677T, MTHFR A1298C, ACE I/D, APOB G10708A, APOE T388C, and APOE C526T were genotyped using ViennaLab StripAssay.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Host genetics impact on SARS-CoV-2 vaccine-induced immunoglobulin levels and dynamics: The role of TP53, ABO, APOE, ACE2, HLA-A, and CRP genes.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Group differences in gait and balance between PD with and without GBA variants were assessed with linear regression, adjusting for age, gender, clinical testing site, disease duration, and apolipoprotein E (APOE) ɛ4 status.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Some common alleles, including APOE, are effectively associated with LOAD identified, but the genetics of LOAD is not clear to date.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “OBJECTIVE: We aimed to assess CNVs regions that may harbor genes contributing to AD, T2DM, and MDD in 67 Saudi familial and sporadic AD patients, with no alterations in the known genes of AD and genotyped previously for APOE.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Therefore, this review represents the role of ketogenic diets to combat AD pathogenesis by considering the influence of APOE.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “METHODS: The APOE alleles in AMD patients were detected by genotyping.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Most of the AD cases are late onset, and the apolipoprotein E (APOE) isoform is a key genetic risk factor.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “All patients were also genotyped for APOE alleles.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “BACKGROUND: Several candidate genes have been identified in relation to lipid metabolism, and among these, lipoprotein lipase (LPL) and apolipoprotein E (APOE) gene polymorphisms are major sources of genetically determined variation in lipid concentrations.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “IMPORTANCE: The role of the apolipoprotein E (APOE) ε4 allele as an effect modifier in lifestyle interventions to prevent cognitive impairment is still unclear.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Previous studies have revealed that obesity is associated with genetic variations including those found in the apolipoprotein E (APOE) gene, which also affects lipid profiles.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Interpreting the Mechanism of APOE (p.Leu167del) Mutation in the Incidence of Familial Hypercholesterolemia; An In-silico Approach.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “In GLACIER, chr19:50121999 at APOE was associated with ΔTG and multiple SNPs in the APOA1/A4/C3/A5 region at genome-wide significance (P < 5 × 10-8), whereas variants in four loci, DOCK7, BRE, SYNE1 and KCNIP1, reached study-wide significance (P < 1.7 × 10-6).” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Higher CAIDE Dementia Risk Score including APOE genotype was additionally related to more pronounced MTA (OR 1.15, 95% CI 1.00-1.30).” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “Apolipoprotein E (APOE) is a glycosylated protein with multiple biological properties.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “INTRODUCTION: Apolipoprotein E (APOE) genotypes influence the phenotype of several neurodegenerative disorders including Alzheimer's and Parkinson disease and may affect schizophrenia pathogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “AIM: To study the association of apolipoprotein E (APOE) polymorphisms with the susceptibility of inflammatory bowel disease (IBD) in Saudi patients.” | 0.98 | hgnc_dict_v1 |
| gene | APOE | “BACKGROUND/AIM: Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk.” | 0.98 | hgnc_dict_v1 |