colorectal cancer
SaudiVarKB evidence summary derived from retained literature mentions.
523Phenotype mentions
100Publications
50Associated gene records
50Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| KRAS | HGNC:6407 | 39 | 39 |
| TP53 | HGNC:11998 | 29 | 29 |
| BRAF | HGNC:1097 | 28 | 28 |
| EGFR | HGNC:3236 | 22 | 22 |
| APC | HGNC:583 | 21 | 21 |
| PIK3CA | HGNC:8975 | 16 | 16 |
| PTEN | HGNC:9588 | 15 | 15 |
| MLH1 | HGNC:7127 | 14 | 14 |
| MSH2 | HGNC:7325 | 10 | 10 |
| NRAS | HGNC:7989 | 10 | 10 |
| PMS2 | HGNC:9122 | 9 | 9 |
| MSH6 | HGNC:7329 | 9 | 9 |
| BAX | HGNC:959 | 9 | 9 |
| BCL2 | HGNC:990 | 6 | 6 |
| CTNNB1 | HGNC:2514 | 6 | 6 |
| ATM | HGNC:795 | 6 | 6 |
| BRCA2 | HGNC:1101 | 6 | 6 |
| GSTM1 | HGNC:4632 | 6 | 6 |
| STAT3 | HGNC:11364 | 5 | 5 |
| BRCA1 | HGNC:1100 | 5 | 5 |
| CCND1 | HGNC:1582 | 5 | 5 |
| GSTP1 | HGNC:4638 | 5 | 5 |
| LDHA | HGNC:6535 | 5 | 5 |
| PCNA | HGNC:8729 | 5 | 5 |
| MUTYH | HGNC:7527 | 5 | 5 |
| IMPACT | HGNC:20387 | 4 | 4 |
| MMP2 | HGNC:7166 | 4 | 4 |
| CD44 | HGNC:1681 | 4 | 4 |
| ATR | HGNC:882 | 4 | 4 |
| IDH1 | HGNC:5382 | 4 | 4 |
| MYC | HGNC:7553 | 4 | 4 |
| CCND3 | HGNC:1585 | 4 | 4 |
| ERBB2 | HGNC:3430 | 4 | 4 |
| ABCC1 | HGNC:51 | 4 | 4 |
| XRCC1 | HGNC:12828 | 4 | 4 |
| RETN | HGNC:20389 | 4 | 4 |
| ABCB1 | HGNC:40 | 3 | 3 |
| CXCL8 | HGNC:6025 | 3 | 3 |
| NOTCH1 | HGNC:7881 | 3 | 3 |
| PALB2 | HGNC:26144 | 3 | 3 |
| SMAD4 | HGNC:6770 | 3 | 3 |
| GSTT1 | HGNC:4641 | 3 | 3 |
| MDM2 | HGNC:6973 | 3 | 3 |
| CLDN2 | HGNC:2041 | 3 | 3 |
| ABCE1 | HGNC:69 | 3 | 3 |
| EPCAM | HGNC:11529 | 3 | 3 |
| CYP1A1 | HGNC:2595 | 3 | 3 |
| PRNCR1 | HGNC:48942 | 3 | 3 |
| PARP1 | HGNC:270 | 2 | 2 |
| CDK4 | HGNC:1773 | 2 | 2 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| V600E | V600E | 2 | 2 |
| rs1042522 | rs1042522 | 2 | 2 |
| rs1136201 | rs1136201 | 2 | 2 |
| rs11571317 | rs11571317 | 2 | 2 |
| p.G12D | p.G12D | 2 | 2 |
| p.G13D | p.G13D | 2 | 2 |
| S33F | S33F | 2 | 2 |
| C677T | C677T | 1 | 1 |
| A1298C | A1298C | 1 | 1 |
| rs1800896 | rs1800896 | 1 | 1 |
| rs1800629 | rs1800629 | 1 | 1 |
| rs731236 | rs731236 | 1 | 1 |
| rs2228570 | rs2228570 | 1 | 1 |
| rs1544410 | rs1544410 | 1 | 1 |
| rs7975232 | rs7975232 | 1 | 1 |
| rs1544410 | rs1544410 | 1 | 1 |
| rs731236 | rs731236 | 1 | 1 |
| p.W577C | p.W577C | 1 | 1 |
| G894T | G894T | 1 | 1 |
| p.Ala771Gly | p.Ala771Gly | 1 | 1 |
| p.Val797Gly | p.Val797Gly | 1 | 1 |
| rs1800469 | rs1800469 | 1 | 1 |
| rs2228570 | rs2228570 | 1 | 1 |
| rs231775 | rs231775 | 1 | 1 |
| rs1264457 | rs1264457 | 1 | 1 |
| rs383369 | rs383369 | 1 | 1 |
| rs7247538 | rs7247538 | 1 | 1 |
| rs7975232 | rs7975232 | 1 | 1 |
| V600E | V600E | 1 | 1 |
| E49R | E49R | 1 | 1 |
| G10R | G10R | 1 | 1 |
| E37K | E37K | 1 | 1 |
| Q61K | Q61K | 1 | 1 |
| Q61* | Q61* | 1 | 1 |
| rs76011559 | rs76011559 | 1 | 1 |
| rs12273047 | rs12273047 | 1 | 1 |
| rs1695 | rs1695 | 1 | 1 |
| rs1138272 | rs1138272 | 1 | 1 |
| rs701848 | rs701848 | 1 | 1 |
| rs2735343 | rs2735343 | 1 | 1 |
| G12D | G12D | 1 | 1 |
| E49K | E49K | 1 | 1 |
| R102Q | R102Q | 1 | 1 |
| G138E | G138E | 1 | 1 |
| V600E | V600E | 1 | 1 |
| W151C | W151C | 1 | 1 |
| L272P | L272P | 1 | 1 |
| A296S | A296S | 1 | 1 |
| A330D | A330D | 1 | 1 |
| R391H | R391H | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026Deciphering Mutational Impacts on c-Src-HK2 Interaction in Colorectal Cancer Progression, and Identification of Potential Phytocompounds Inhibitors: A Molecular Simulation and Free Energy Calculation Approach.Current medicinal chemistry1 mentions
- 2026AQP9 and IFITM1 as drivers of immune infiltration and tumor progression in IBD-associated colorectal cancer: from computational insights to experimental validation.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026Oral and Maxillofacial Manifestations of Gardner Syndrome: A Literature Analysis.The Journal of craniofacial surgery1 mentions
- 2026Pharmacophore-based high-throughput virtual screening (HTVS) to identify new c-Src kinase inhibitors with anticancer potential.Bioorganic & medicinal chemistry1 mentions
- 2026Disruption of NANOG-driven epithelial-mesenchymal transition (EMT) and self-renewal restores drug sensitivity in colorectal cancer.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy1 mentions
- 2026Benchmarking pathology foundation models for predicting microsatellite instability in colorectal cancer histopathology.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society1 mentions
- 2026CRISPR/Cas9-mediated claudin-2 knockout in HCT116 cells reveals its key role in colorectal cancer progression.Oncology letters1 mentions
- 2026Study of the association of LILRB2 gene polymorphisms with colorectal cancer susceptibility and prognosis in Tunisian population.Human immunology1 mentions
- 2026Unveiling Tamarix articulata phytochemicals as novel natural inhibitors of colon cancer: A holistic drug design and toxicological approach.Journal of molecular graphics & modelling1 mentions
- 2026HLA-E gene polymorphism and expression in colorectal cancer patients.Human immunology1 mentions
- 2026Synthesis, characterization, and anticancer evaluation of N-Heterocyclic entities: ADME profiling and In Silico predictions.Toxicology reports1 mentions
- 2026Compact deep learning models for colon histopathology focusing performance and generalization challenges.Scientific reports1 mentions
- 2026Analysis of Risk Factors and Assessment of miRNA-122 as a Novel Biomarker for Colon Cancer in Egyptian Patients.Asian Pacific journal of cancer prevention : APJCP1 mentions
- 2026Profound alterations of cancer transcriptomes by the RNase L inhibitor ABCE1 through the modulation of UU/UA-dinucleotide rich transcript abundance.RNA biology1 mentions
- 2026Cubosomal nanoparticles of lycopene as a novel platform for enhancement in antioxidant and anticancer properties with a molecular docking study.Scientific reports1 mentions
- 2026EGFR as a biomarker in colorectal Cancer: An electrochemical biosensing approach.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2026Unlocking the Role of Exosomal ncRNAs in Colorectal Cancer: Molecular Insights and Clinical Promise.Current pharmaceutical design1 mentions
- 2026Poliovirus receptor (PVR) expression as a predictor of relapse in colorectal cancer: bioinformatics and virtual screening.Experimental biology and medicine (Maywood, N.J.)1 mentions
- 2026Pericytes and mesenchymal stromal cells converge toward pro-tumor phenotypes in the tumor microenvironment.Discover oncology1 mentions
- 2026KRAS Variant Frequency and Colorectal Cancer-Specific Survival by Race and Ethnicity.JAMA network open1 mentions
- 2026The global cancer crisis: a review of growing burden, deepening inequality and initiatives for prevention and early detection.Ecancermedicalscience1 mentions
- 2026Bioactivity-Guided Fractionation of the Bidah Pomegranate Landrace Identifies a Bioactive Fraction Inducing Mitochondria-Associated Apoptotic Responses in Colorectal Cancer Cells.International journal of molecular sciences1 mentions
- 2026Deciphering the Molecular Interactions of Tuberculosis and Colorectal Cancer: A Network and RNA-Seq Data Analysis Approach.Anti-cancer agents in medicinal chemistry1 mentions
- 2026Clinical Discovery and Molecular Analysis of Two Novel MSH2 Gene Mutations (p.Ala771Gly and p.Val797Gly) in Saudi Colorectal Cancer Patients: Potential Implications for Tumorigenesis.Health science reports1 mentions
- 2026A comprehensive analysis of the Cullin family reveals that CUL5 and CUL7 promote colorectal cancer progression and serve as prognostic markers.Hereditas1 mentions
- 2026Integrative Multi-Omics and Molecular Simulations Identify PRKCD as a Biological Modulator in Colon Adenocarcinoma: Validation With Phoenix dactylifera Phytochemicals and Comparison With Rottlerin.Chemical biology & drug design1 mentions
- 2026Metal accumulation in paired colon cancer and adjacent tissues and its relationship with genotoxic and epigenetic biomarkers.Frontiers in public health1 mentions
- 2026Fucosylation Dynamics as a Critical Determinant of Cancer Cell Fate in Colorectal Carcinoma: Integrating Hallmark Plasticity, Microenvironmental Remodelling, and Therapeutic Resistance.Biology1 mentions
- 2026The Colorectal Cancer Glycocode: Tumour Sialylation Is Associated with an Immune-Excluded Phenotype and Distinct Therapeutic Signatures.Biology1 mentions
- 2026N-Substituted-2-(9H-Xanthen-9-yl)acetamide Derivatives Induce In Vitro Colon Cancer Cell Death via TASK-1 Inhibition: Lead Compounds for Further Optimization as TASK-1-Targeted Therapeutics in Colorectal Cancer.International journal of molecular sciences1 mentions
- 2026The ATP-adenosine axis as a driver of tumor-associated macrophage reprogramming in colorectal cancer: mechanistic insights into immune evasion and therapeutic vulnerabilities.Purinergic signalling1 mentions
- 2026Comparative molecular analysis of colorectal cancer in Saudi Arabia: distinct genetic alterations and clinical features.Frontiers in oncology1 mentions
- 2026Molecular and Immune Profiling of Sessile Serrated Adenomas/Polyps Reveals Prognostic Genes and Immune Cell Dynamics in Colorectal Cancer Progression.Applied biochemistry and biotechnology1 mentions
- 2026Modulating claudin-2 with CRISPR-Cas9 to improve photodynamic therapy outcomes in colorectal cancer.Tissue & cell1 mentions
- 2026Targeting DNMT1 restores PTEN expression in colorectal cancer cells.Molecular and cellular probes1 mentions
- 2026A QbD optimization of a pH-responsive Eudragit S100-chitosan nanoformulation for the co-delivery of pentoxifylline and simvastatin in colorectal cancer therapy.RSC advances1 mentions
- 2026Efficient colorectal cancer classification from histopathological images utilizing lightweight convolutional neural networks.Computers in biology and medicine1 mentions
- 2026O-Glycosylation Signatures Shape the Tumour Immune Microenvironment and Associate with Genomic Stability, Drug Resistance Programmes, and Epithelial Differentiation in Colorectal Cancer.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2026Tissue-Agnostic Targeting in Solid Tumors: A PRISMA-Compliant Meta-Analysis of Efficacy, Safety, and Resistance Determinants Across Histologies.Oncology research1 mentions
- 2026Green synthesis of ZnO/Fe3O4 nanocomposites from Citrus reticulata peel: antibacterial activity against MDR Acinetobacter baumannii, CRISPR-Cas gene modulation, and anticancer potential.RSC advances1 mentions
- 2026Irisin Potentiates 5-fluorouracil Cytotoxicity in HT-29 Colon Cancer Cells through Enhanced Apoptosis and Transcriptional Modulation of Adenosine Monophosphate-activated Protein Kinase/Mammalian Target of Rapamycin Signaling.International journal of applied & basic medical research1 mentions
- 2026Liposomal honokiol attenuates dimethylhydrazine-induced colon carcinogenesis in rats through modulation of oxidative stress, inflammation, apoptosis, autophagy, and lipid metabolism pathways.Medical oncology (Northwood, London, England)1 mentions
- 2025Genomic Landscape of Advanced Solid Tumors in Middle East and North Africa Using Circulating Tumor DNA in Routine Clinical Practice.Oncology1 mentions
- 2025Prevalence of SPOP and IDH Gene Mutations in Prostate Cancer in a Jordanian Population.Biochemical genetics1 mentions
- 2025Visible-light-induced CO-releasing properties and cytotoxicity of a Ru(II) carbonyl complex containing 2-(pyridin-2-yl)-quinoxaline.Dalton transactions (Cambridge, England : 2003)1 mentions
- 2025Investigation of GSTP1 and PTEN gene polymorphisms and their association with susceptibility to colorectal cancer.Radiology and oncology1 mentions
- 2025Targeting the Hippo and Rap1 signaling pathways: the anti-proliferative effects of curcumin in colorectal cancer cell lines.Medical oncology (Northwood, London, England)1 mentions
- 2025A review on the effects of flavan-3-ols, their metabolites, and their dietary sources on gut barrier integrity.Food & function1 mentions
- 2025Relationship between inherited genetic variation and survival from colorectal cancer stratified by tumour location.Scientific reports1 mentions
- 2025Schiff bases targeting an Sw-480 colorectal cell line: synthesis, characterization, ds-DNA binding and anticancer studies.RSC advances1 mentions
- 2025The mutational spectrum of NRAS gene discovers a novel frameshift mutation (E49R) in Saudi colorectal cancer patients.Cancer cell international1 mentions
- 2025Discovery of PPAR Alpha Lipid Pathway Modulators That Do Not Bind Directly to the Receptor as Potential Anti-Cancer Compounds.International journal of molecular sciences1 mentions
- 2025Nutraceutical Impact of Pumpkin Seed Oil on Expression Levels of EZH-2 and KRT-14 Genes against DSS-induced Inflammatory Bowel Disease in the Rat Model.Cell biochemistry and biophysics1 mentions
- 2025First Case of Tracheobronchopathia Osteochondroplastica in an 82-Year-Old Patient From Saudi Arabia.Laryngoscope investigative otolaryngology1 mentions
- 2025The incidence of venous thromboembolism by type of solid cancer worldwide: A systematic review.Cancer epidemiology1 mentions
- 2025A Computational Recognition Analysis of Promising Prognostic Biomarkers in Breast, Colon and Lung Cancer Patients.International journal of molecular sciences1 mentions
- 2025Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology1 mentions
- 2025Chitosan-Coated Silver Nanourchins for Imatinib Mesylate Delivery: Biophysical Characterization, In-Silico Profiling, and Anti-Colon Cancer Efficacy.Molecular pharmaceutics1 mentions
- 2025Discovery of a selective PI3Kα inhibitor via structure-based virtual screening for targeted colorectal cancer therapy.Journal of enzyme inhibition and medicinal chemistry1 mentions
- 2025Deciphering the anticancer potential of thymoquinone: in-depth exploration of the potent flavonoid from Nigella sativa.Molecular biology reports1 mentions
- 2025Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link.Journal of the National Cancer Center1 mentions
- 2025Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation.Journal of the Egyptian National Cancer Institute1 mentions
- 2025Costs of Adverse Event Management Associated with First-Line Cetuximab or Panitumumab in Metastatic Colorectal Cancer Patients in Saudi Arabia.Journal of health economics and outcomes research1 mentions
- 2025Dissociation between the expression of cGAS/STING and a senescence-associated signature in colon cancer.International journal of immunopathology and pharmacology1 mentions
- 20256-Paradol enhances sorafenib's effects against colorectal cancer and promotes active metabolite formation.Pathology, research and practice1 mentions
- 2025Recent Update of Natural Compounds as HIF-1α Inhibitors in Colorectal Carcinoma.Drug design, development and therapy1 mentions
- 2025Vitexin's Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational Approaches.Recent patents on anti-cancer drug discovery1 mentions
- 2025Probiotics in colorectal cancer prevention and therapy: mechanisms, benefits, and challenges.Discover oncology1 mentions
- 2025Flavonoids and their role in oxidative stress, inflammation, and human diseases.Chemico-biological interactions1 mentions
- 2025Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development.Open medicine (Warsaw, Poland)1 mentions
- 2025Effectiveness of Tumor-induced Mesenchymal Stem Cells on Cell Growth and Development in Different Cancer Types In Vitro and In Vivo Models.Archives of medical research1 mentions
- 2025New alkanesulfonate-based quinazolinone-acetohydrazide scaffolds: Rational design, synthesis, molecular docking, anticancer properties and potential EGFR and its T790M/L858R mutants inhibitors.Bioorganic chemistry1 mentions
- 2025Isolation, Screening, and Identification of Staphylococcus epidermidis with Effective Probiotic Attributes.Current microbiology1 mentions
- 2025Exploring the molecular pathways of advanced rectal cancer: A focus on genetic, RNA, and biological technique.Pathology, research and practice1 mentions
- 2025Artificial intelligence in inflammatory bowel disease.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association1 mentions
- 2025Zapotin mitigates breast cancer progression by targeting PKCε mediated glycolytic pathway regulation.BMC cancer1 mentions
- 2025Increased protein expression of interleukin-10 and its signalling molecules in colon cancer progression: potential prognostic and therapeutic targets.Discover oncology1 mentions
- 2025Dynamic comprehensive learning-based dung beetle optimizer using triangular mutation for polyps image segmentation.Computational biology and chemistry1 mentions
- 2025Anthocyanins: From Natural Colorants to Potent Anticancer Agents.Food science & nutrition1 mentions
- 2025The gastrointestinal mycobiome in inflammation and cancer: unraveling fungal dysbiosis, pathogenesis, and therapeutic potential.Medical oncology (Northwood, London, England)1 mentions
- 2025Incidental low-grade appendiceal mucinous neoplasm in Crohn's disease patient post ileocecal resection: a case report.Journal of surgical case reports1 mentions
- 2025Propranolol and Capecitabine Synergy on Inducing Ferroptosis in Human Colorectal Cancer Cells: Potential Implications in Cancer Therapy.Cancers1 mentions
- 2025Expression Profile of Serum CircFUNDC1 and CircUHRF1 Can Differentiate Between Colorectal Cancer and Inflammatory Bowel Diseases (Ulcerative Colitis and Crohn's Disease).Journal of clinical laboratory analysis1 mentions
- 2025Synergistic Inhibition of Colon Cancer Cell Proliferation via p53, Bax, and Bcl-2 Modulation by Curcumin and Plumbagin Combination.ACS omega1 mentions
- 2025Ileal pouch-anal anastomosis in familial adenomatous polyposis and ulcerative colitis with coexisting colorectal cancer: a guideline for treatment.Journal of surgical case reports1 mentions
- 2025Triazole-quinoxaline attenuates epithelial-to-mesenchymal transition by suppressing the Wnt/β-catenin pathway in human colorectal cancer cells.Archives of biochemistry and biophysics1 mentions
- 2025Comparative in silico analyses between Lactiplantibacillus plantarum and Bifidobacterium longum concerning probiotic properties, anti-lipidemic, and anti-diabetic in vitro activities.BMC microbiology1 mentions
- 2025Imiquimod-Loaded Phospholipid-Free Small Unilamellar Vesicles Activate the Tumor Immune Microenvironment to Treat Liver Cancer and Liver Metastases.Advanced healthcare materials1 mentions
- 2025Effects of PIK3CA Gene Modifications on Radiosensitivity in Colorectal Cancer Cells.Asian Pacific journal of cancer prevention : APJCP1 mentions
- 2025Probiotics and Cancer: Mechanistic Insights and Organ-Specific Impact.Biomolecules1 mentions
- 2025PARP Inhibition in Colorectal Cancer-A Comparison of Potential Predictive Biomarkers for Therapy.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2025In-silico analysis of potential phytochemicals targeting mitogen activating protein kinase-14 (MAPK14) gene in colorectal cancer.Scientific reports1 mentions
- 2025Investigating the genetic landscape of cancer in Jordan: a step toward personalized care.European journal of medical research1 mentions
- 2025Phyto-Fabrication Tribulus terrestris Mediated Iron Oxide Nanoparticles: A Promising Approach of Antioxidant and Anticancer Activities via in vitro and in silico Studies.Frontiers in bioscience (Landmark edition)1 mentions
- 2025The Significance of STAT3 in Colonic Diseases: A Comprehensive Study of Pathological Roles and Therapeutic Implications.Cell biochemistry and biophysics1 mentions
- 2025ABCE1 facilitates tumour progression via aerobic glycolysis and inhibits cell death in human colorectal cancer cells through the p53 signalling pathway.Scientific reports1 mentions
- 2025USP6NL knockdown suppresses colorectal cancer progression by inducing CASP9-Mediated apoptosis and disrupting FOXC2/SNAI1-Driven EMT and angiogenesis.Functional & integrative genomics1 mentions
- 2025Utilizing of Seaweed for Eco-friendly Synthesis of Nickel Cobalt Nanoparticles and Assessment of its Cytotoxic Effects on Human Liver and Colon Cancer Cells.Dose-response : a publication of International Hormesis Society1 mentions
- 2025A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy.Food science & nutrition1 mentions
- 2025Long-Term Survival for Locally Advanced Adenosquamous Carcinoma Colon Cancer in Ulcerative Colitis: A Case Report.Case reports in oncology1 mentions