hypertension
SaudiVarKB evidence summary derived from retained literature mentions.
746Phenotype mentions
100Publications
50Associated gene records
50Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| ACE | HGNC:2707 | 7 | 7 |
| ACE2 | HGNC:13557 | 7 | 7 |
| MTHFR | HGNC:7436 | 6 | 6 |
| PAH | HGNC:8582 | 4 | 4 |
| LDLR | HGNC:6547 | 4 | 4 |
| GSTT1 | HGNC:4641 | 4 | 4 |
| MMP9 | HGNC:7176 | 3 | 3 |
| AGT | HGNC:333 | 3 | 3 |
| GSTM1 | HGNC:4632 | 3 | 3 |
| BMPR2 | HGNC:1078 | 3 | 3 |
| SLC2A10 | HGNC:13444 | 2 | 2 |
| APOE | HGNC:613 | 2 | 2 |
| TBX4 | HGNC:11603 | 2 | 2 |
| TG | HGNC:11764 | 2 | 2 |
| G6PD | HGNC:4057 | 2 | 2 |
| STAT3 | HGNC:11364 | 2 | 2 |
| ABCB1 | HGNC:40 | 2 | 2 |
| HSD11B2 | HGNC:5209 | 2 | 2 |
| AKT1 | HGNC:391 | 2 | 2 |
| MALAT1 | HGNC:29665 | 2 | 2 |
| HLA-B | HGNC:4932 | 2 | 2 |
| ABO | HGNC:79 | 2 | 2 |
| INS | HGNC:6081 | 2 | 2 |
| VDR | HGNC:12679 | 2 | 2 |
| SCN5A | HGNC:10593 | 2 | 2 |
| PCSK9 | HGNC:20001 | 2 | 2 |
| EGFR | HGNC:3236 | 2 | 2 |
| CYP1B1 | HGNC:2597 | 2 | 2 |
| TLR4 | HGNC:11850 | 2 | 2 |
| FAS | HGNC:11920 | 2 | 2 |
| MMP1 | HGNC:7155 | 2 | 2 |
| KLF2 | HGNC:6347 | 2 | 2 |
| MIAT | HGNC:33425 | 2 | 2 |
| CYP17A1 | HGNC:2593 | 2 | 2 |
| HSP90AA1 | HGNC:5253 | 2 | 2 |
| CACNA1C | HGNC:1390 | 2 | 2 |
| CD46 | HGNC:6953 | 2 | 2 |
| PIGN | HGNC:8967 | 2 | 2 |
| GATA4 | HGNC:4173 | 2 | 2 |
| TMPRSS2 | HGNC:11876 | 2 | 2 |
| MAPK14 | HGNC:6876 | 2 | 2 |
| EIF2AK4 | HGNC:19687 | 2 | 2 |
| FOXP3 | HGNC:6106 | 1 | 1 |
| TNF | HGNC:11892 | 1 | 1 |
| ABCB4 | HGNC:45 | 1 | 1 |
| NLRP3 | HGNC:16400 | 1 | 1 |
| AIDA | HGNC:25761 | 1 | 1 |
| PSEN2 | HGNC:9509 | 1 | 1 |
| AK2 | HGNC:362 | 1 | 1 |
| LPL | HGNC:6677 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| C677T | C677T | 3 | 3 |
| p.Arg208Cys | p.Arg208Cys | 2 | 2 |
| A1298C | A1298C | 2 | 2 |
| rs699 | rs699 | 2 | 2 |
| c.1256G>A | c.1256G>A | 1 | 1 |
| p.Arg1624Trp | p.Arg1624Trp | 1 | 1 |
| p.Arg83Cys | p.Arg83Cys | 1 | 1 |
| p.Gln20Arg | p.Gln20Arg | 1 | 1 |
| c.622C>T | c.622C>T | 1 | 1 |
| rs2232365 | rs2232365 | 1 | 1 |
| rs1800629 | rs1800629 | 1 | 1 |
| rs1056827 | rs1056827 | 1 | 1 |
| rs11568818 | rs11568818 | 1 | 1 |
| rs1320632 | rs1320632 | 1 | 1 |
| p.H288Y | p.H288Y | 1 | 1 |
| G20210A | G20210A | 1 | 1 |
| p.W577C | p.W577C | 1 | 1 |
| p.R416H | p.R416H | 1 | 1 |
| p.R239Q | p.R239Q | 1 | 1 |
| p.Y329X | p.Y329X | 1 | 1 |
| p.Q334X | p.Q334X | 1 | 1 |
| p.R335X | p.R335X | 1 | 1 |
| p.R182H | p.R182H | 1 | 1 |
| p.Q264X | p.Q264X | 1 | 1 |
| rs3802230 | rs3802230 | 1 | 1 |
| rs4543 | rs4543 | 1 | 1 |
| rs4544 | rs4544 | 1 | 1 |
| rs4646994 | rs4646994 | 1 | 1 |
| p.Cys571Ser | p.Cys571Ser | 1 | 1 |
| p.Thr389Met | p.Thr389Met | 1 | 1 |
| p.Met467Lys | p.Met467Lys | 1 | 1 |
| G894T | G894T | 1 | 1 |
| c.662C>T | c.662C>T | 1 | 1 |
| G20210A | G20210A | 1 | 1 |
| G679S | G679S | 1 | 1 |
| G66A | G66A | 1 | 1 |
| E22E | E22E | 1 | 1 |
| G68A | G68A | 1 | 1 |
| R23K | R23K | 1 | 1 |
| G2035A | G2035A | 1 | 1 |
| rs2108622 | rs2108622 | 1 | 1 |
| c.1127A>G | c.1127A>G | 1 | 1 |
| G52T | G52T | 1 | 1 |
| rs2228570 | rs2228570 | 1 | 1 |
| p.I27L | p.I27L | 1 | 1 |
| rs1333048 | rs1333048 | 1 | 1 |
| rs10757278 | rs10757278 | 1 | 1 |
| rs12248560 | rs12248560 | 1 | 1 |
| rs4646994 | rs4646994 | 1 | 1 |
| rs1800795 | rs1800795 | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026In Silico Characterization of Bromo-DragonFLY Binding to the 5-HT2A Receptor: Molecular Insights Into a Potent Designer Psychedelic.Proteins1 mentions
- 2026Pharmacogenomic insights into angiotensin converting enzyme inhibitors and calcium channel blockers for personalized hypertension treatment.Journal of hypertension1 mentions
- 2026Characterizing Alzheimer's Disease and Related Dementia in a Hypertension Population Within the State of Florida Using Electronic Health Record-Based Data.Clinical pharmacology and therapeutics1 mentions
- 2026GDF-15 as an integrative cardiometabolic biomarker.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2026Comparative study of obeticholic acid and rosuvastatin in high-fat/fructose diet-induced metabolic dysfunction: role of AMPK, PPAR-γ, SREBP-1c, and STAT3 pathways.Journal of molecular histology1 mentions
- 2026Giant Right Coronary Artery Aneurysm With Left Ventricular Fistula: A Rare Coronary Anomaly.JACC. Case reports1 mentions
- 2026Whole-exome sequencing in obstructive coronary artery disease identifies rare and novel variants in cardiac arrhythmia and pulmonary arterial hypertension-associated genes.Biomolecules & biomedicine1 mentions
- 2026Reappraising cardiac function with myocardial contraction fraction: normal values, disease detection, and prognostication.European heart journal. Cardiovascular Imaging1 mentions
- 2026Comparative analysis of the morphological heterogeneity of smooth muscle cells in two avian species: the muscovy Duck (Cairina moschata) and the Japanese quail (Coturnix japonica): ultrastructural and histochemical study.Protoplasma1 mentions
- 2026Post-Myocardial Infarction Prognostic Factors and Mortality in the Gulf Region: A Systematic Review and Meta-Analysis.Current cardiology reviews1 mentions
- 2026Hypoxia-inducible factor-1α in cardiovascular disease, mechanistic insights, pathophysiological roles, and therapeutic targeting strategies.Biochemical pharmacology1 mentions
- 2026Incidentally discovered developmental venous anomaly with an associated white matter changes in a 7-year-old girl: a case report and literature review.Journal of surgical case reports1 mentions
- 2026National Heart Center/Saudi Heart Association 2025 Guidelines for Cardiovascular Diseases Prevention and Risk Assessment.Saudi medical journal1 mentions
- 2026Prognostic Impact of New-Onset Atrial Fibrillation After Cardiac Arrest: Observations From a Federated Research Network.Journal of cardiovascular electrophysiology1 mentions
- 2026Identifying NDUFA12 mutation in a Saudi family: An unusual presentation of mitochondrial Complex I deficiency mimicking as idiopathic intracranial hypertension in a patient with papilledema and visual loss.Journal of family & community medicine1 mentions
- 2026Beta-Blockers After Myocardial Infarction Without Reduced Ejection Fraction: A Meta-Analysis of Kaplan-Meier Reconstructed Individual Patient Data.American journal of cardiovascular drugs : drugs, devices, and other interventions1 mentions
- 2026Management of Tricuspid Regurgitation in Patients with Rheumatic Mitral Disease.Portuguese journal of cardiac thoracic and vascular surgery1 mentions
- 2026Mesenchymal stem cell-conditioned media alleviates diabetic cardiomyopathy by modulating glycemic control, oxidative stress-induced injury and inflammation regulation.Journal of diabetes and metabolic disorders1 mentions
- 2026The long-term impact of early HbA1c control on nephropathy, neuropathy, and retinopathy in type 2 diabetes: Findings from a large UK observational study.Journal of diabetes and its complications1 mentions
- 2026From post-infectious glomerulonephritis to complement-mediated aHUS: a diagnostic challenge.Pediatric nephrology (Berlin, Germany)1 mentions
- 2026Biological implications and therapeutic potential of phosphodiesterase inhibitors: A review.Medicine1 mentions
- 2026Unrepaired Truncus Arteriosus Type 1 With Eisenmenger Syndrome and Recurrent Embolic Strokes: An Adult Case Report.The American journal of case reports1 mentions
- 2026Association of Monocyte Chemoattractant Protein-1 and Endothelin-1 Genes with Cardiac Pro-Β-Type Natriuretic Peptide Levels in Obese Hypertensive Patients.Current pharmaceutical design1 mentions
- 2026Pegcetacoplan-induced remission in pediatric immune-complex membranoproliferative glomerulonephritis with comorbid autosomal recessive polycystic kidney disease: a case report.Frontiers in medicine1 mentions
- 2026Clinical outcomes in Caroli disease and Caroli syndrome: a longitudinal observational cohort study.Scientific reports1 mentions
- 2026Traditional cardiovascular risk factors and their association with atherosclerotic cardiovascular disease in homozygous familial hypercholesterolemia: A cross-sectional analysis from the HICC registry.Atherosclerosis1 mentions
- 2026Angiotensin-converting enzyme insertion/deletion gene polymorphism in children with nephrotic syndrome: Genotype-phenotype correlations.Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia1 mentions
- 2026Cardiac safety of sofosbuvir-based direct-acting antivirals in hepatitis C patients with pre-existing heart disease.Clinics (Sao Paulo, Brazil)1 mentions
- 2026Association of P2Y12 G52T genetic polymorphism with recurrent thromboembolic events in stroke and myocardial infarction patients on clopidogrel therapy: a prospective observational study.Scientific reports1 mentions
- 2026Early targeted neonatal echocardiography identifies biventricular dysfunction and pulmonary hypertension associated with death or severe bronchopulmonary dysplasia in infants born before 29 weeks' gestation.Frontiers in pediatrics1 mentions
- 2026Persistent Bilateral Optic Disc Swelling in Non-Syndromic Retinitis Pigmentosa: A Case Report.The American journal of case reports1 mentions
- 2026A patent review of VEGFR-2 inhibitors: an update (2022 - present).Expert opinion on therapeutic patents1 mentions
- 2026Optimization and evaluation of different fast acting tablet formulations containing bisoprolol fumarate.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society1 mentions
- 2026A case report on the effective and safe use of ravulizumab in atypical hemolytic uremic syndrome during pregnancy.BMC nephrology1 mentions
- 2026Genetic analysis and clinical phenotype of pulmonary arterial hypertension in an Algerian population.Annals of Saudi medicine1 mentions
- 2026Scimitar Syndrome and Pulmonary Hypertension in Pediatric Population: A Retrospective Analysis of the Prevalence, Clinical Characteristics, Risk Factors, and Outcomes.Pulmonary circulation1 mentions
- 2026Modulation of the serotonergic system restores oxidative balance and gene expression in the brain and heart of rats with obesity induced by overnutrition.Frontiers in physiology1 mentions
- 2026The Role of Platelet-to-Neutrophil Ratio as a Biomarker for Pulmonary Hypertension in Sickle Cell Disease Patients: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania)1 mentions
- 2026Jagged-1 mutation is associated with congenital heart defects: a case report.Journal of medical case reports1 mentions
- 2026Assessment of antibiotic prophylaxis post cardiac implantable electronic device implantation: a retrospective cohort study.BMC infectious diseases1 mentions
- 2026Epidemiology and clinical outcomes of carbapenamase-producing organism (CPO) colonization: a tertiary care center experience in Saudi Arabia.BMC infectious diseases1 mentions
- 2026Evaluation of the antihypertensive and antihyperlipidaemic effects of a pyrimidine derivative in preventing cardiometabolic risk.British journal of pharmacology1 mentions
- 2026Autonomic-vascular dysregulation in CKD-associated hypertension: a narrative review with evidence hierarchy.Frontiers in neuroscience1 mentions
- 2026Critical Pertussis in the PICU: Multinational Study in the Gulf Cooperation Council Region, 2022-2024.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies1 mentions
- 2026Hospital-Based Proportion of Diabetic Retinopathy and Associated Risk Factors Among Patients With Type 2 Diabetes Mellitus.Cureus1 mentions
- 2026Exercise pulmonary hypertension in asymptomatic patients with HIV infection Insights from the RIGHT-NET registry.European journal of internal medicine1 mentions
- 2026Sotatercept reduces bone morphogenetic protein signaling in patients with pulmonary arterial hypertension.Science translational medicine1 mentions
- 2026Chromium as a Modulator of Insulin Receptor Activity: A Systematic Review of Its Role in Metabolic Syndrome and Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy1 mentions
- 2026Medication Use and Guideline Adherence in Inflammatory Bowel Disease Management: A Retrospective Study from a Tertiary Care Hospital in Pakistan (2019-2024).International journal of general medicine1 mentions
- 2026NLRs and preeclampsia: Advances in etiology, pathogenesis, and therapeutic targeting, highlighting NLRP3.Reproductive biology1 mentions
- 2026Epidemiological Trends and Burden of Adult Kidney Cancer in Saudi Arabia: A 42-Year Retrospective Analysis (1982-2023).Cancer reports (Hoboken, N.J.)1 mentions
- 2026Diallyl trisulfide attenuates metabolic syndrome via integrated modulation of PCSK-9/LDL-R axis, redox homeostasis, and inflammatory cytokine networks in high-carbohydrate high-fat (HCHF) diet-fed rats.Frontiers in pharmacology1 mentions
- 2026Clinical phenotypes and mortality predictors in pediatric critical pertussis: A multinational study.Journal of infection and public health1 mentions
- 2026KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension.Communications biology1 mentions
- 2026Premature atherosclerotic cardiovascular disease in the MENA region: economic impact, barriers to care, and policy recommendations for an escalating crisis.Current opinion in lipidology1 mentions
- 2026An Ancient Founder GDF2 Variant Potentially Causes Semi-Dominant Non-Syndromic Pulmonary Arterial Hypertension.Clinical genetics1 mentions
- 2026The Angiotensin II Receptor Antagonist Losartan Impairs Female Fertility in Rats: Potential Mediating Role of microRNA-129-1-3p.Journal of applied toxicology : JAT1 mentions
- 2026Chrononutrition and cardiometabolic health: circadian timing as a dimension of precision nutrition.Frontiers in nutrition1 mentions
- 2026A Hematologic Masquerader: Progressive Familial Intrahepatic Cholestasis Type 3 Presenting as Anemia, Hepatosplenomegaly, and Recurrent Bleeding in a Child.Clinical case reports1 mentions
- 2026Cardioprotective Effect of Aloin Against Ischemia/Reperfusion Injury: Experimental and Computational POM Approaches.Journal of biochemical and molecular toxicology1 mentions
- 2026Association Between Metabolic Syndrome and Prostate Cancer: A Systematic Review.Cancers1 mentions
- 2026Single-Center Experience in Pediatric Lung Transplantation: Clinical Characteristics, Survival, and Post-Transplant Morbidity.Pediatric transplantation1 mentions
- 2026Lack of association between the Cytochrome P450 4F2 rs2108622 genotype and responses to valsartan and amlodipine among a sample of Jordanian hypertensive patients.Prostaglandins & other lipid mediators1 mentions
- 2025Clinical and echocardiographic predictors of outcome in liver transplant patients.Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace1 mentions
- 2025Novel technique utilizing polymethylmethacrylate cement for the treatment of pulsatile tinnitus caused by different sigmoid sinus pathologies.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery1 mentions
- 2025Biochemical investigation of FOXP3 genetic polymorphism and its association with biochemical parameters in pre-eclampsia patients.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2025Gout in pregnancy: Obstetric and neonatal outcomes.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics1 mentions
- 2025Mitochondrial dysfunction and calcium homeostasis in heart failure: Exploring the interplay between oxidative stress and cardiac remodeling for future therapeutic innovations.Current problems in cardiology1 mentions
- 2025Maternal epilepsy and pregnancy, delivery and neonatal outcomes: A population-based retrospective cohort study.Epilepsy & behavior : E&B1 mentions
- 2025The impact of new-onset atrial fibrillation in the setting of acute coronary syndrome.Journal of cardiology1 mentions
- 2025Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry.European heart journal1 mentions
- 2025Pregnancy, delivery, and neonatal outcomes among women with beta-thalassemia major: a population-based study of a large US database.Archives of gynecology and obstetrics1 mentions
- 2025Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach.Biogerontology1 mentions
- 2025The clinical assessment of lung involvement in patients with Still's disease, results from the multicentre international AIDA Network Still's Disease Registry.Rheumatology (Oxford, England)1 mentions
- 2025Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome-An Update.Medicina (Kaunas, Lithuania)1 mentions
- 2025Genomic Insights into Blood Pressure Regulation: Exploring Ion Channel and Transporter Gene Variations in Jordanian Hypertensive Individuals.Medicina (Kaunas, Lithuania)1 mentions
- 2025Prophylactic vs therapeutic blood transfusions impact on pregnant sickle cell patients.Pakistan journal of medical sciences1 mentions
- 2025Unusual presentation of anomalous origin of the right pulmonary artery from the ascending aorta: case report.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology1 mentions
- 2025Anomalous origin of the left main coronary artery in a 62‑year‑old woman: a case report and review of the literature.Journal of cardiothoracic surgery1 mentions
- 2025Connexin 43 Affects Pulmonary Artery Reactivity via Changes in Nitric Oxide Production and Influences Proliferative and Migratory Responses in Mouse Pulmonary Artery Fibroblasts.International journal of molecular sciences1 mentions
- 2025Efficacy of Tirzepatide Dual GIP/GLP-1 Receptor Agonist in Patients With Idiopathic Intracranial Hypertension. A Real-World Propensity Score-Matched Study.Endocrinology, diabetes & metabolism1 mentions
- 2025USG-guided bilateral sphenopalatine ganglion block: A useful anesthetic adjuvant for trans nasal trans sphenoidal pituitary surgery in a patient with severely low ejection fraction.Saudi journal of anaesthesia1 mentions
- 2025Ictal vomiting as an unusual presentation of herpes simplex encephalitis - Pathophysiological and therapeutic perspectives.IDCases1 mentions
- 2025Bowel Obstruction Due to the Mesenteric Mass Being an Enteritis Cystica Profunda: A Case Report.Cureus1 mentions
- 2025Hermansky-Pudlak Syndrome Type 1 Presenting with Interstitial Lung Disease: A Report of a Rare Case from Saudi Arabia.The American journal of case reports1 mentions
- 2025Prevalence and Factors Associated With Hepatitis C Virus in Riyadh, Saudi Arabia: A Large Cross-Sectional Study.Journal of epidemiology and global health1 mentions
- 2025Computational and molecular insights on non-synonymous SNPs associated with human RAAS genes: Consequences for Hypertension vulnerability.Journal, genetic engineering & biotechnology1 mentions
- 2025Plasma Atrial Natriuretic Peptide Predicts Oxidized Low-Density Lipoprotein Levels in Type 2 Diabetes Mellitus Patients Independent of Circulating Adipokine and Cytokine.International journal of molecular sciences1 mentions
- 2025Risk Factors of Post-Craniotomy Surgical Site Infection: A Retrospective Study.Surgical infections1 mentions
- 2025Microscope-Assisted Hypertensive Retinopathy Diagnosis Using Deep Learning Models.Microscopy research and technique1 mentions
- 2025Predictors of Outcomes in Pediatric Pulmonary Arterial Hypertension.Journal of the Saudi Heart Association1 mentions
- 2025Unraveling the Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic Interventions.International journal of molecular sciences1 mentions
- 2025Flavonoids and their role in oxidative stress, inflammation, and human diseases.Chemico-biological interactions1 mentions
- 2025Clinical characterization of blood pressure phenotypes: the BP phenotype score.Blood pressure1 mentions
- 2025Global Effect of Cardiovascular Risk Factors on Lifetime Estimates.The New England journal of medicine1 mentions
- 2025Therapeutic potential of allosteric HECT E3 ligase inhibition.Cell1 mentions
- 2025The Lancet Commission on rethinking coronary artery disease: moving from ischaemia to atheroma.Lancet (London, England)1 mentions
- 2025A 65-Year-Old Man with Coronary Artery Embolism and Acute Inferior Myocardial Infarction Following Cardioversion for Ventricular Tachycardia.The American journal of case reports1 mentions
- 2025Epidemiology and Clinical Impact of Vancomycin-Resistant Enterococcus at King Abdulaziz University Hospital (2015-2022): Prevalence, Risk Factors, and Mortality.International journal of general medicine1 mentions
- 2025Public knowledge and awareness of gout among adults in Jeddah, Saudi Arabia: A cross-sectional study.Medicine1 mentions