breast cancer
SaudiVarKB evidence summary derived from retained literature mentions.
842Phenotype mentions
100Publications
50Associated gene records
50Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| BRCA1 | HGNC:1100 | 86 | 86 |
| BRCA2 | HGNC:1101 | 57 | 57 |
| EGFR | HGNC:3236 | 44 | 44 |
| TP53 | HGNC:11998 | 41 | 41 |
| ESR1 | HGNC:3467 | 19 | 19 |
| PIK3CA | HGNC:8975 | 18 | 18 |
| BAX | HGNC:959 | 17 | 17 |
| STAT3 | HGNC:11364 | 12 | 12 |
| PTEN | HGNC:9588 | 12 | 12 |
| CDK4 | HGNC:1773 | 10 | 10 |
| ATM | HGNC:795 | 9 | 9 |
| RAD51 | HGNC:9817 | 9 | 9 |
| ABCB1 | HGNC:40 | 8 | 8 |
| CDKN1A | HGNC:1784 | 7 | 7 |
| MTHFR | HGNC:7436 | 7 | 7 |
| BCL2 | HGNC:990 | 7 | 7 |
| AKT1 | HGNC:391 | 7 | 7 |
| CCND1 | HGNC:1582 | 7 | 7 |
| PALB2 | HGNC:26144 | 7 | 7 |
| CDH1 | HGNC:1748 | 7 | 7 |
| MDM2 | HGNC:6973 | 7 | 7 |
| BRAF | HGNC:1097 | 6 | 6 |
| MMP9 | HGNC:7176 | 6 | 6 |
| CD44 | HGNC:1681 | 6 | 6 |
| PARP1 | HGNC:270 | 5 | 5 |
| SIRT1 | HGNC:14929 | 5 | 5 |
| KRAS | HGNC:6407 | 5 | 5 |
| FGFR2 | HGNC:3689 | 5 | 5 |
| E2F1 | HGNC:3113 | 5 | 5 |
| RAD50 | HGNC:9816 | 5 | 5 |
| CXCR4 | HGNC:2561 | 5 | 5 |
| ERBB2 | HGNC:3430 | 5 | 5 |
| BARD1 | HGNC:952 | 5 | 5 |
| XRCC1 | HGNC:12828 | 5 | 5 |
| CTLA4 | HGNC:2505 | 4 | 4 |
| JAK2 | HGNC:6192 | 4 | 4 |
| GSTP1 | HGNC:4638 | 4 | 4 |
| IDH1 | HGNC:5382 | 4 | 4 |
| SKP2 | HGNC:10901 | 4 | 4 |
| CENPF | HGNC:1857 | 4 | 4 |
| CYP1A1 | HGNC:2595 | 4 | 4 |
| TOP2A | HGNC:11989 | 4 | 4 |
| XRCC3 | HGNC:12830 | 4 | 4 |
| CD4 | HGNC:1678 | 3 | 3 |
| AR | HGNC:644 | 3 | 3 |
| TG | HGNC:11764 | 3 | 3 |
| BIRC5 | HGNC:593 | 3 | 3 |
| SOD1 | HGNC:11179 | 3 | 3 |
| COL11A1 | HGNC:2186 | 3 | 3 |
| COMT | HGNC:2228 | 3 | 3 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| rs11614913 | rs11614913 | 2 | 2 |
| rs2234693 | rs2234693 | 2 | 2 |
| rs2770150 | rs2770150 | 2 | 2 |
| rs1801320 | rs1801320 | 2 | 2 |
| rs2910164 | rs2910164 | 2 | 2 |
| G135C | G135C | 2 | 2 |
| c.4136_4137delCT | c.4136_4137delCT | 2 | 2 |
| rs25487 | rs25487 | 2 | 2 |
| rs1799794 | rs1799794 | 2 | 2 |
| C677T | C677T | 1 | 1 |
| rs1801133 | rs1801133 | 1 | 1 |
| c.1813C>T | c.1813C>T | 1 | 1 |
| p.L605F | p.L605F | 1 | 1 |
| rs1800629 | rs1800629 | 1 | 1 |
| rs1544410 | rs1544410 | 1 | 1 |
| rs731236 | rs731236 | 1 | 1 |
| rs1801131 | rs1801131 | 1 | 1 |
| rs1042522 | rs1042522 | 1 | 1 |
| p.W577C | p.W577C | 1 | 1 |
| G894T | G894T | 1 | 1 |
| C677T | C677T | 1 | 1 |
| R721G | R721G | 1 | 1 |
| A756D | A756D | 1 | 1 |
| Y791C | Y791C | 1 | 1 |
| E734K | E734K | 1 | 1 |
| E805K | E805K | 1 | 1 |
| F893L | F893L | 1 | 1 |
| R897Q | R897Q | 1 | 1 |
| R897G | R897G | 1 | 1 |
| R912Q | R912Q | 1 | 1 |
| R912G | R912G | 1 | 1 |
| M918T | M918T | 1 | 1 |
| p.Met918Thr | p.Met918Thr | 1 | 1 |
| p.Arg897Gln | p.Arg897Gln | 1 | 1 |
| C797S | C797S | 1 | 1 |
| p.R304Q | p.R304Q | 1 | 1 |
| p.R175H | p.R175H | 1 | 1 |
| E17K | E17K | 1 | 1 |
| rs6700986 | rs6700986 | 1 | 1 |
| rs952804 | rs952804 | 1 | 1 |
| rs1236161858 | rs1236161858 | 1 | 1 |
| rs367917640 | rs367917640 | 1 | 1 |
| rs202071893 | rs202071893 | 1 | 1 |
| rs757469768 | rs757469768 | 1 | 1 |
| rs9939609 | rs9939609 | 1 | 1 |
| rs1703863535 | rs1703863535 | 1 | 1 |
| V114G | V114G | 1 | 1 |
| C189R | C189R | 1 | 1 |
| C189Y | C189Y | 1 | 1 |
| W608R | W608R | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026Exploring a kinase inhibitor targeting PI3KCA mutant cancer cells.Journal of biomolecular structure & dynamics1 mentions
- 2026Integrated computational and biological evaluations of newly synthesized thiadiazole-based VEGFR-2 inhibitors with targeted anti-breast cancer activity.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026Advances in prognostic and predictive biomarkers for breast cancer: Integrating multigene assays, hormone receptors, and emerging circulating biomarkers.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2026The synergistic effect of resveratrol and curcumin on oncogenic lncRNA MAPT-IT1 and ferroptosis-related genes in breast cancer.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026Immunogenic mutanome of breast cancer: Advances, challenges and future directions in neoantigen-based immunotherapy.Advances in clinical and experimental medicine : official organ Wroclaw Medical University1 mentions
- 2026CRISPR-Edited Cell Lines: A New Era in Functional Oncology Research.Current pharmaceutical design1 mentions
- 2026Cardiovascular safety of CDK4/6 inhibitors in advance breast cancer: Assessing risks of QTc prolongation and thrombosis.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners1 mentions
- 2026Biochemical landscape of breast cancer: integrating serum markers with clinical prognosis and staging.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico1 mentions
- 2026Multiscale Pancancer Analysis Uncovers Intrinsic Imaging and Molecular Characteristics Prominent in Breast Cancer and Glioblastoma.British journal of cancer1 mentions
- 2026TP53 apoptosis biomarkers in breast cancer.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2026Suppression of NGALR impedes TNBC cell survival, proliferation, invasion, and migration through Akt/mTOR and JAK/STAT3 pathway inhibition.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico1 mentions
- 2026Expression of Tetraspanin 4 Relative to Therapy-induced Senescence Markers in Breast Cancer in Response to Neoadjuvant Chemotherapy.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society1 mentions
- 2026Artificial intelligence in breast cancer: clinical applications in diagnosis, prognosis, and therapeutics.Future oncology (London, England)1 mentions
- 2026The advancements in targeted therapeutic strategies for breast cancer via intervention of natural molecules: An insight into cellular and molecular mechanisms.Pathology, research and practice1 mentions
- 2026Arugula-derived isothiocyanates as novel agents for a potential regulator of AKR1B10 protein in breast cancer: an integrated transcriptomic and molecular docking approach.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026Stimulator of interferon genes (STING)-activating nanomedicines: Translating innate immune modulation into effective therapy for triple-negative breast cancer.Clinical and translational medicine1 mentions
- 2026Integrated in silico and in vitro evaluation of Genistein and Apigenin as dual inhibitors of PARP1 and ESR1 in breast cancer.BMC pharmacology & toxicology1 mentions
- 2026Bacterial contributions to cancer development: mechanisms, dysbiosis, and cross-cancer associations.Infectious agents and cancer1 mentions
- 2026Subtype-Specific m6A circRNA Methylation Patterns Identify Epigenetic Biomarker Candidates of Potential Diagnostic and Prognostic Significance in Breast Cancer.International journal of molecular sciences1 mentions
- 2026PEAO: a bio-inspired parallel optimizer with a multi-strategy communication mechanism for breast cancer diagnosis.Scientific reports1 mentions
- 2026Association between elevated PRIM1 expression and poor prognosis in human urothelial carcinoma.Journal of Taibah University Medical Sciences1 mentions
- 2026Domain Shift in Breast DCE-MRI Tumor Segmentation: A Balanced LoCoCV Study on the MAMA-MIA Dataset.Diagnostics (Basel, Switzerland)1 mentions
- 2026Safety and preliminary efficacy of adding tocilizumab to cisplatin/docetaxel for the treatment of locally advanced triple-negative breast cancer patients: prospective phase 1/2 clinical trial.Scientific reports1 mentions
- 2026Jervine-induced suppression of triple-negative breast cancer (TNBC) cells growth through the regulation of Wnt signaling pathway- an in-silico and in-vitro approach.Journal of computer-aided molecular design1 mentions
- 2026In Vitro Anti-Cancer Effects of Artemisia sieberi on Human Breast Cancer Cells: A Systematic Review.Journal of evidence-based integrative medicine1 mentions
- 2026Identification of BRCA1 and BRCA2 Germline Mutations in Female Breast Cancer Patients Using Next Generation Sequencing.Asian Pacific journal of cancer prevention : APJCP1 mentions
- 2026Structural reprogramming of irradiated ellagic acid suppresses cell cycle regulators and modulates cytokines via activation of the p53/BAX-CASP3/Bcl-2-cyclin D1 pathway: Validation studies across breast cancer cell lines.International journal of biological macromolecules1 mentions
- 2026AdaptiveInvolutionNet: Spatially-adaptive involution with channel-wise attention for breast MRI tumor classification.PloS one1 mentions
- 2026Differential responses to the combination of navitoclax and venetoclax with doxorubicin in murine models of triple negative breast cancer.Frontiers in cell and developmental biology1 mentions
- 2026Exome-Wide Association Analysis Identifies Rare Germline Susceptibility Variants in Early-Onset Breast Cancer Among Saudi Women.International journal of molecular sciences1 mentions
- 2026Breast-Cancer-Derived Secretomes from MCF-7 Cells Modulate Bacterial Pathogenic Traits.International journal of molecular sciences1 mentions
- 2026Global, regional, and national burden of breast cancer among females, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023.The Lancet. Oncology1 mentions
- 2026Injectable etoposide-loaded dextran nanoparticles for breast cancer treatment: physicochemical characterization, cytotoxicity studies, macrophage activity, and gene expression profiling.Nanomedicine (London, England)1 mentions
- 2026Clinicopathological Landscape and Survival Outcomes of HER2-Low Breast Cancer in a Large Arab Cohort.World journal of surgery1 mentions
- 2026Global prevalence and ethnic variation of pathogenic BRCA1/2 variants in breast cancer: a systematic review and meta-analysis.Journal of translational medicine1 mentions
- 2026IDH enzyme inhibition in cancer therapy: mechanisms, mutational insights, and effects of IDH inhibitors in glioma, acute myeloid leukemia and chondrosarcoma.3 Biotech1 mentions
- 2026A comparison of honeybee and scorpion venoms as anticancer agents against three different cancer cell lines: lung, colon, and breast cancer.Frontiers in toxicology1 mentions
- 2026Expression of Bruton's Tyrosine Kinase Reflects Immune Cells Infiltration and Cell Proliferation in Breast Cancer.World journal of oncology1 mentions
- 2026Prediction of Specific Survival and Clinicopathological Impact of Somatic PALB2 Mutations and Pathogenic/Likely Pathogenic Variants (PV/LPV) in Breast Cancer: A Cohort Study of 81 Patients.International journal of surgical pathology1 mentions
- 2026Marine Klebsiella sp. RR1-mediated AgNPs functionalized with matcha: synthesis, characterization, and evaluation of antibacterial, antioxidant, anti-inflammatory, and gene regulation of breast cancer potentials.Microbial cell factories1 mentions
- 2026Eugenoplatin (a phyto-chemo drug conjugate) targets cancer stem cells through inhibition of the β-catenin signaling in triple-negative breast cancer cells.Journal of translational medicine1 mentions
- 2026Awareness and attitudes toward BRCA1/2 genetic testing among at-risk women in Egypt.Patient education and counseling1 mentions
- 2026The global cancer crisis: a review of growing burden, deepening inequality and initiatives for prevention and early detection.Ecancermedicalscience1 mentions
- 2026STK11 and DNA Repair Gene Mutations Define Hereditary Subset of Middle Eastern Papillary Thyroid Cancer.International journal of molecular sciences1 mentions
- 2026Tumor-Intrinsic PD-L1 Promotes Breast Cancer Proliferation Through Livin and Galectin-1-Mediated Regulation of SKP2 Expression.International journal of molecular sciences1 mentions
- 2026Insights into the prognostic significance of cell division cycle 25A (CDC25A) in breast cancer.Journal of clinical pathology1 mentions
- 2026Machine learning-based DNA microarray analysis for disease detection using the MICRO-AI framework.Science progress1 mentions
- 2026Machine learning-driven drug repurposing for HER2-positive breast cancer.Scientific reports1 mentions
- 2026CAR-T cell therapy in breast cancer management: expanding horizon and overcoming challenges beyond hematologic cancers.Molecular biology reports1 mentions
- 2026Leveraging a Multienzymes-Mimicking Nanozyme to Overcome CDK4/6 Inhibitor Resistance and Achieve Drug Repurposing in Oesophageal Squamous Cell Carcinoma.Small (Weinheim an der Bergstrasse, Germany)1 mentions
- 2026Fam-trastuzumab deruxtecan in a patient with metastatic human epidermal growth factor receptor 2-positive breast cancer and pre-existing cardiac failure: a case report.AME case reports1 mentions
- 2026MMTV Virus Detection, Survival Analysis, and Prognostic Relevance of Six Tumor Genes in Patients With Breast Cancer.International journal of breast cancer1 mentions
- 2026Design and synthesis of novel isatin-isoniazidhydrazone hybrid-based 1,2,3-triazoles as dual EGFR/PARP-1 inhibitors and apoptosis inducers in breast cancer cells.Bioorganic chemistry1 mentions
- 2026ISG15 as a novel serum biomarker for breast Cancer: Diagnostic and prognostic significance, clinical laboratory applications, and multi-biomarker integration strategies.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2026Population-specific MicroRNA biomarker discovery in breast ductal carcinoma via explainable graph neural multi-omics modeling.BMC cancer1 mentions
- 2026Personalized mRNA vaccine for breast cancer: in silico neoantigen discovery and immunogenic validation in a Pakistani patient cohort.In silico pharmacology1 mentions
- 2026Peganum harmala leaf extract mediated green synthesised polyvinyl alcohol zinc oxide beta cyclodextrin nanocomposite for anticancer and antimicrobial applications.Discover nano1 mentions
- 2026Modifying Epigenetic Landscapes to Restore Immune Therapeutic Responses in Triple Negative Breast Cancer.Cancers1 mentions
- 2026Whole exome sequencing reveals rare DNA repair gene variants in BRCA1/2-negative Arab early-onset breast cancer patients.Scientific reports1 mentions
- 2026Clinical utility of the HFA-ICOS risk tool in real-world HER2-positive breast cancer patients receiving therapy.Cardio-oncology (London, England)1 mentions
- 2026Advances in PARP Inhibition in Improving Outcomes of Breast Cancer, Ovarian Cancer, and Other Solid Tumors: Journey of Discovery, Development, and Clinical Updates of Talazoparib.Drug design, development and therapy1 mentions
- 2026Precision breast oncology: molecular insights and transformative clinical strategies.Cancer treatment and research communications1 mentions
- 2026Dose-dependent neurotoxic effects of anastrozole via disrupting NLRP3 inflammasome and α-synuclein pathways.Tissue & cell1 mentions
- 2026Circadian rhythms as orchestrators of breast cancer metastasis: From molecular mechanisms to chronotherapeutic interventions.Cancer letters1 mentions
- 2026Ethanolic extract of Otostegia fruticosa induces ROS-dependent apoptosis and reduces migration of MDA-MB-231 cells in vitro.PloS one1 mentions
- 2026Erucin Targets Oncogenic Signaling Pathways in Triple-Negative Breast Cancer: An Integrated Network Pharmacology and In Vitro Study.Life (Basel, Switzerland)1 mentions
- 2026Decitabine Induces Subtype-Specific Epigenomic Remodeling and Perturbs Age-Associated Regulatory CpGs in Breast Cancer.Cancer informatics1 mentions
- 2026Low Frequency of Pathogenic Variants in BRCA1 Exons 11/20 and BRCA2 Exon 11 Suggests Divergent Mutational Hotspots in Sudanese Breast Cancer Patients: A Case-Control Study.Breast cancer : basic and clinical research1 mentions
- 2026Evaluation of XRCC4 and VEGF Gene Variants in Relation to Breast Cancer Risk in a Jordanian Cohort.Cancer management and research1 mentions
- 2026State-Aware RNA Biomarkers in Triple-Negative Breast Cancer (TNBC): Integrating Tumor Plasticity, Spatial Architecture, and Temporal Monitoring.International journal of molecular sciences1 mentions
- 2026The Human Breast Microbiome: From Homeostasis to Malignancy, Mechanistic Insights and Therapeutic Perspectives.International journal of molecular sciences1 mentions
- 2026Evaluation of PD-L1 Expression and Systemic Inflammatory Blood Cell Ratios as Prognosticators in Advanced Lung, Breast and Head and Neck Cancers.Cancers1 mentions
- 2026Vitamin D-related genetic variants as predictive biomarkers for breast cancer in Jordanian women.Frontiers in medicine1 mentions
- 2026Novel Monoazo Dispersion Dyes Incorporating a 4-thiazolidinone Moiety: Synthesis, Structural Characterization, Molecular Docking, and Anticancer Investigations.Current medicinal chemistry1 mentions
- 2026Multitargeted comparative evaluation suggests 2-Aoeobenoxmide shows favourable in silico binding compared to Tucatinib against ERα, HER2, AKT1, EGFR, and PIK3CA in breast cancer.Scientific reports1 mentions
- 2026Expression and Survival Analysis Show High Mobility Group (HMG) Family as Prognostic Biomarkers in Breast Cancer.European journal of breast health1 mentions
- 2026Structure-based discovery of PARP15 inhibitors with enhanced binding energetics and stability via quantum refinement for targeted breast cancer therapy.Computational biology and chemistry1 mentions
- 2026Assessing the Association Between Genetic Variants in ACE, SOD1, and PER3 and their Role in Breast Cancer Risk among Jordanian Women.Journal of Cancer1 mentions
- 2026Synthesis and multilevel evaluation of benzimidazole-based anticancer compounds: DNA/serum albumin interaction, and in-depth theoretical insights.Molecular and cellular biochemistry1 mentions
- 2026Post-CDK4/6 Inhibitor Therapeutic Approaches in Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: Current Evidence and Emerging Strategies-A Narrative Review.Diagnostics (Basel, Switzerland)1 mentions
- 2026Tissue-Agnostic Targeting in Solid Tumors: A PRISMA-Compliant Meta-Analysis of Efficacy, Safety, and Resistance Determinants Across Histologies.Oncology research1 mentions
- 2026Modeling the Effects of Single Nucleotide Polymorphisms (SNPs) on the Structure and Function of the Human RET Gene: An In Silico Study.Human mutation1 mentions
- 2026Decoding PARP roles in breast cancer therapy resistance.Molecular biology reports1 mentions
- 2026Chemical profiling and in silico evaluation of a Matricaria chamomilla L. extract: exploring its antioxidant, antibacterial, antidiabetic, anti-inflammatory, and anticholinergic activities.Frontiers in nutrition1 mentions
- 2025Doxorubicin-sanguinarine nanoparticles: formulation and evaluation of breast cancer cell apoptosis and cell cycle.Drug development and industrial pharmacy1 mentions
- 2025Phosphoinositide 3-Kinase Inhibitors from Gladiolus Segetum Ker-Gawl Corms Supported by Network Pharmacology.Chemistry & biodiversity1 mentions
- 2025Genomic Landscape of Advanced Solid Tumors in Middle East and North Africa Using Circulating Tumor DNA in Routine Clinical Practice.Oncology1 mentions
- 2025Associations between BCL-2 expression and different histopathological prognostic factors in different molecular subtypes of invasive breast carcinoma of no special type.Histology and histopathology1 mentions
- 2025Design, Synthesis, and Molecular Docking of Quinazolines Bearing Caffeoyl Moiety for Targeting of PGK1/PKM2/STAT3 Signaling Pathway in the Human Breast Cancer.Current pharmaceutical design1 mentions
- 2025The functional TNF-α-308G > a single-nucleotide polymorphism (rs1800629): association with the predictive indices of breast cancer carcinogenesis.Breast cancer research and treatment1 mentions
- 2025Nanoparticulate drug combination inhibits DNA damage repair and PD-L1 expression in BRCA-mutant and wild type triple-negative breast cancer.Journal of controlled release : official journal of the Controlled Release Society1 mentions
- 2025Cell division cycle 6 is an independent prognostic biomarker in breast cancer.Pathology1 mentions
- 2025Evidence-based advancements in breast cancer genetic counseling: a review.Breast cancer (Tokyo, Japan)1 mentions
- 2025Network Pharmacology and In silico Elucidation of Phytochemicals Extracted from Ajwa Dates (Phoenix dactylifera L.) to Inhibit Akt and PI3K Causing Triple Negative Breast Cancer (TNBC).Current pharmaceutical design1 mentions
- 2025Gold nanoparticles mediate suppression of angiogenesis and breast cancer growth via MMP-9/NF-κB/mTOR and PD-L1/PD-1 signaling: integrative in vitro validation and network pharmacology insights.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2025Exploring the role of exosomal lncRNA in cancer immunopathogenesis: Unraveling the immune response and EMT pathways.Experimental cell research1 mentions
- 2025CircRNAs in extracellular vesicles associated with triple-negative breast cancer.Cellular and molecular biology (Noisy-le-Grand, France)1 mentions
- 2025Elevated MRPS23 expression facilitates aggressive phenotypes in breast cancer cells.Cellular and molecular biology (Noisy-le-Grand, France)1 mentions
- 2025Exploration of Novel Therapeutic Targets for Breast Carcinoma and Molecular Docking Studies of Anticancer Compound Libraries with Cyclin-dependent Kinase 4/6 (CDK4/6): A Comprehensive Study of Signalling Pathways for Drug Repurposing.Current pharmaceutical design1 mentions
- 2025Cordycepin and Its Structural Derivatives Effectively Suppress the High Expression of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase in Breast Carcinomas: A Computational Drug Development Approach.Current medicinal chemistry1 mentions