JAK2
HGNC:6192 · 63 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | JAK2 | “Myeloproliferative neoplasms (MPNs) present a fundamental paradox: despite sharing a small set of canonical driver mutations in JAK2, CALR, or MPL, patients exhibit striking heterogeneity in disease latency, clinical presentation, and evolutionary trajectories to myelofibrosis or secondary acute myeloid leukemia.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Clonal hematopoiesis of indeterminate potential (CHIP) describes the proliferation of blood cell clones that carry driver mutations, such as DNA methyltransferase 3 alpha (DNMT3A), ten-eleven translocation 2 (TET2), additional sex combs like 1 (ASXL1), and Janus kinase 2 (JAK2), without leading to any obvious malignancy.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Interaction profiling confirmed stable binding through hydrogen bonding, hydrophobic, and π-interactions with BAX, ASC, GSDMD, KIM-1, JAK2, NLRP3, and miRNA-155.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Specifically, the JAK2/STAT3 pathway is a key mediator of cardiac repair and defence mechanisms.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Molecular crosstalk between lncRNA H19, miR-29a, and JAK2/STAT3 signaling in alopecia areata: a preliminary study.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “In silico molecular docking was performed to assess the binding affinity and interaction profiles of campesterol with target proteins, including JAK2, TNF-α, and NF-κB, which are involved in inflammatory pathways.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Alpha‑lipoic acid-loaded chitosan nanoparticles ameliorate streptozotocin‑induced diabetic liver injury via Nrf2/HO‑1 activation and TLR4/NF‑κB and JAK2/STAT1 inhibition.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “AIM OF THE STUDY: The purpose of the current study is to elucidate the defending strategies of Citrus aurantifolia (Christm.) Swingle (Rutaceae) essential oil (CAEO) in the amelioration of MTX induced hepatic and kidney toxicities focusing on the Nrf2/HO-1 and JAK2/STAT3/NF-κB pathways.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Ph-like ALL is a high-risk subtype with diverse genomic alterations, including CRLF2 rearrangements, JAK2/EPOR mutations, and ABL-class fusions, which are targetable but underdiagnosed in low and middle-income countries (LMICs).” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “The activation of these cell surface receptors results in functional responses including cellular proliferation, differentiation, survival, and maturation via multiple signaling pathways such as JAK2/STAT5, MAPK, and PI3-kinase/AKT.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Four constituents of A. alba-Avicenol B, Avicenol C, Avicequinone B, and Avicequinone C-were verified, leading to the identification of 10 hub genes (i.e., EGFR, PIK3CA, JAK2, MTOR, JUN, ERBB2, IGF2, SRC, MDM2, and PARP1) associated with CRC.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Citronellol Induces Apoptosis via Differential Regulation of Caspase-3, NF-κB, and JAK2 Signaling Pathways in Glioblastoma Cell Line.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “MATERIALS AND METHODS: We employed computational approaches like high-throughput virtual screening, molecular dynamics simulations (MDS), and binding free energy calculations to identify inhibitors targeting wild and mutant JAK2 kinases.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “JAK2/STAT3/NFκB gene expression was measured.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Background The Janus kinase 2 (JAK2) V617F mutations are related to increased thrombotic risk in patients with myeloproliferative disorders (MPDs).” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Laboratory data involved the hematological parameters (hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, hematocrit, white blood cells, red blood cells, and platelets) and real-time PCR JAK2 V617F mutation qualitative assay.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “OBJECTIVES: To systematically review evidence on the prevalence of the JAK2V617F (JAK2) mutation and polycythemia vera (PV) among all blood donors, focusing on those with elevated hematocrit.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “ADMET properties of the active compound Patuletin (MOL004112) were assessed, followed by 200 ns molecular dynamics simulations to examine its stability in complex with JAK2.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “JAK2 Mutation Assessment in Thrombotic Events at Unusual Anatomical Sites: Insights from a High-Altitude Cohort.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Further analysis identified 5 core/ hub targets of CN including JAK2, ERK1, ESR1, GSK3B and HSP90AA1.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “This panel was designed to sequence the complete genome of CALR, IDH1, IDH2, JAK2, FLT3, NPM1, MPL, TET2, SF3B1, TP53, and MLL.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Leo was also found to impart STAT3 inhibition by mitigating the activation of upstream kinases such as JAK1, JAK2, and Src both in constitutive and IL-6 inducible systems.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Moreover, the study suggests at the potential role of other related genes such as IL-23Rβ1, TYK2, or JAK2 in IFN-γ production, warranting further investigation.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Administration of MSCs improved dyslipidemia, the altered cardiac injury biomarkers (p ≤ 0.0001), downregulated Janus kinase 2/signal transducer and activator of transcription 3(JAK2/STAT3)/inducible Nitric oxide synthase (iNOS) and iNOS/Apoptosis signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Perindopril Ameliorates Sodium Valproate-Induced Rat Model of Autism: Involvement of Sirtuin-1, JAK2/STAT3 Axis, PI3K/Akt/GSK-3β Pathway, and PPAR-Gamma Signaling.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Computational modeling and in vitro evaluation identified natural product-Z218 as a novel Janus kinase 2 (JAK2) inhibitor to combat β-thalassemia.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “The FISH study was negative for BCR::ABL1, JAK2, PDGFRA, PDGFRB, and FGFR1 rearrangements.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “For instance, many patients with myeloproliferative neoplasms carry the acquired gain-of-function JAK2 V617F somatic mutation.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Our results showed that the docking affinity from 4Z16 (JAK3 wild-type model), 4E4N (JAK1), 4D1S (JAK2), and 7UYT (TYK2) from the Schrödinger software suite agreed well with the experimentally derived binding free energies with small predicted mean errors.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “A 68-Year-Old Man with a Cytogenetic Diagnosis of Chronic Myeloid Leukemia and Bone Marrow Findings of Philadelphia Chromosome Translocation Between the Long Arm of Chromosomes 9 and 22, Leading to the BCR-ABL1 Fusion Gene and V617F Mutation in the JAK2 Gene.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm driven by canonical gene mutations in JAK2, CALR, or MPL in >80% of the cases.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Moreover, these treatments downregulated the colonic inflammatory cascade by inhibiting NFκB, TNFα, IL-1β, IL6, IL23, IL17, COX-2, and iNOS, subsequently leading to downregulation of the JAK2/STAT3 signaling pathway and a decrease in the Th17 cell response.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “The expression levels of apoptosis and autophagy markers, JAK2 and STAT3 were determined using quantitative real time-PCR (qRT-PCR) and western blotting methods.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “These predictions are corroborated by molecular docking results, where we noticed that NOD2 and IL23R missense variants induce molecular interaction deformities with RIPK2 and JAK2 ligand molecules, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “OBJECTIVE: Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway activation is initiated by mutations in the JAK2 gene.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Oral squamous cell carcinoma with essential thrombocythemia and positive JAK2 (V617F) mutation.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Screening of V617F mutation in JAK2 gene with acute myeloid leukemia in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “JAK2 (OD 2.5) alteration was associated with increased percentage of CD177pos neutrophils.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “It is an end result of a genetic mutation of one or more of the most frequent oncogenes such as Janos kinase 2 (JAK2), MPL proto-oncogene, thrombopoietin receptor (MPL), and calreticulin (CALR).” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Familial thrombocytosis (FT) is a rare hereditary haematological disorder characterised by increased platelet count, usually caused by germ-line mutations in thrombopoietin (THPO), myeloproliferative leukaemia virus oncogene (MPL) or Janus kinase 2 (JAK2) genes, and can be associated with increased risk of thrombosis.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “BCR-ABL1 oncoprotein activates various molecular pathways including the RAS/RAF/MEK/ERK pathway, JAK2/STAT pathway, and PI3K/AKT/mTOR pathway.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Immunoblot analysis showed that mutant CSF2RB signals through JAK2/STAT and PI3K/mTOR pathways in ligand starvation conditions.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Janus kinase 2 gene (JAK2) V617F mutation was positive in two of 26 patients (7.7%).” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Curcumin down-regulates SHH pathways, epigallocatechin-3-gallate regulates the Notch pathway and inhibits TGFβ1/SMAD signalling, and resveratrol regulates the Wnt/β-catenin pathway and carnosic acid-induced apoptosis in colon cancer cell via JAK2/STAT3 signalling pathway.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Notably, no former studies have linked JAK2/STAT3, HMGB1/NF-κB, and Nrf2/HO-1 signaling in TNBS-evoked colitis.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “JAK2 Inhibition by Fedratinib Reduces Osteoblast Differentiation and Mineralisation of Human Mesenchymal Stem Cells.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “3FC downregulated the constitutive phosphorylation of STAT3 and non-receptor tyrosine kinases such as JAK1 and JAK2.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “We noted that LDL induced a substantial STAT3 activation and JAK1, JAK2, Src activation in diverse prostate and pancreatic tumor cells.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “The algorithm identified the following variables prior to HCT that impacted overall survival: age, TP53 mutations, absolute neutrophils count, cytogenetics per International Prognostic Scoring System-Revised, Karnofsky performance status, conditioning regimen, donor age, WBC count, hemoglobin, diagnosis of therapy-related MDS, peripheral blast percentage, mutations in RAS pathway, JAK2 mutation, number of mutations/sample, ZRSR2, and CUX1 mutations.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Ectopic PD-L1 expression in JAK2 (V617F) myeloproliferative neoplasm patients is mediated via increased activation of STAT3 and STAT5.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “A number of concurrent and cooperating mutations clearly play a role in modulating the proliferative potential of cells, including mutations in KIT, FLT3, and possibly JAK2.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “JAK2 and Beyond: Mutational Study of JAK2V617 in Myeloproliferative Disorders and Haematological Malignancies in Kashmiri population.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Genetic and environmental factors can cause mutation in several genes like tyrosine kinase, JAK2 gene which may initiate cancer.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Interestingly, all of EGFR, JAK2, NR3C1, PDZD2, and SEMA3C genes had single nucleotide polymorphisms (SNP) in castration-resistant prostate cancer, consistent with high selection pressure on these genes during drug treatment and consequent resistance.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Janus kinases (JAKs) are a family of non-receptor tyrosine kinases, composed by four members, JAK1, JAK2, JAK3 and TYK2.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “CONCLUSION: Our data suggest that PH inhibits STAT3 activity in Sor-sensitive and -resistant HCCs via SHP-1-mediated inhibition of STAT3 and AKT/mTOR/JAK2/VEGFR2 pathway.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “The most frequently reported genetic aberration among polycythemia vera (PV) patients is a gain of function mutation V617F in exon 14 of Janus kinase 2 (JAK2) gene.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “At two loci (JAK2 and A1CF), experimental analysis in mice showed lipid changes consistent with the human data.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “We found that GAC 17:1 can inhibit constitutive activation of STAT3 through the abrogation of upstream JAK2, Src but not of JAK1 kinases in U266 cells and also found that GAC can suppress IL-6-induced STAT3 phosphorylation in MM.1S cells.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “Detection of mutations in JAK2 exons 12-15 by Sanger sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “STAT3 suppression was mediated through the inhibition of activation of upstream JAK2, but not of JAK1 and Src kinases.” | 0.98 | hgnc_dict_v1 |
| gene | JAK2 | “We further demonstrated that SCRS data amplified by either MDA or MALBAC from a gastric cancer cell line could accurately detect gastric cancer CNVs with comparable sensitivity and specificity, including amplifications of 12p11.22 (KRAS) and 9p24.1 (JAK2, CD274, and PDCD1LG2).” | 0.98 | hgnc_dict_v1 |