FLG
HGNC:3748 · SaudiVarKB evidence summary derived from retained literature mentions.
11Gene mentions
11Publications
9Linked variants
5Associated phenotypes
Associated phenotypes
Co-mentioned in FLG publications| Phenotype | Identifier | Articles | Mentions |
|---|---|---|---|
| atopic dermatitis | — | 4 | 4 |
| asthma | — | 2 | 2 |
| allergic rhinitis | — | 2 | 2 |
| epilepsy | HP:0001250 | 1 | 1 |
| neurodevelopmental disorder | HP:0012759 | 1 | 1 |
Linked variants
Variants normalized to FLG| Variant | HGVS / rsID | Articles | Mentions |
|---|---|---|---|
| rs12130219 | rs12130219 | 1 | 1 |
| rs61816761 | rs61816761 | 1 | 1 |
| rs558269137 | rs558269137 | 1 | 1 |
| rs12144049 | rs12144049 | 1 | 1 |
| rs3126085 | rs3126085 | 1 | 1 |
| rs471144 | rs471144 | 1 | 1 |
| rs6661961 | rs6661961 | 1 | 1 |
| rs61816764 | rs61816764 | 1 | 1 |
| rs9303277 | rs9303277 | 1 | 1 |
Population context
Reported in the same publications| Country / region | Group | Cohort | Articles |
|---|---|---|---|
| Saudi Arabia | — | — | 1 |
| Saudi Arabia | — | 35 | 1 |
| Saudi Arabia | — | 20 | 1 |
| Not specified | — | 700 | 1 |
| Not specified | — | 474 | 1 |
| Not specified | — | 262 | 1 |
| Not specified | — | 4,205 | 1 |
Supporting publications
11 records- 2025Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity.Immunity, inflammation and diseasePubMed ↗
- 2023Manuka honey activates the aryl hydrocarbon receptor: Implications for skin inflammation.Pharmacological researchPubMed ↗
- 2023Filaggrin gene variants among Saudi patients with ichthyosis vulgaris.BMC medical genomicsPubMed ↗
- 2022Polymorphisms of the filaggrin gene are associated with atopic dermatitis in the Caucasian population of Central Russia.GenePubMed ↗
- 2022Clinical and genetic characterization of patients segregating variants in KPTN, MINPP1, NGLY1, AP4B1, and SON underlying neurodevelopmental disorders: Genetic and phenotypic expansion.International journal of developmental neuroscience : the official journal of the International Society for Developmental NeurosciencePubMed ↗
- 2022Whole-Exome Sequencing Reveals Migraine-Associated Novel Functional Variants in Arab Ancestry Females: A Pilot Study.Brain sciencesPubMed ↗
- 2021Missense, silent, non-sense and frame-shift mutations in exon 3 of the filaggrin gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy.Nucleosides, nucleotides & nucleic acidsPubMed ↗
- 2021Novel Homozygous Mutations in the Genes TGM1, SULT2B1, SPINK5 and FLG in Four Families Underlying Congenital Ichthyosis.GenesPubMed ↗
- 2021Filaggrin gene polymorphisms are associated with atopic dermatitis in women but not in men in the Caucasian population of Central Russia.PloS onePubMed ↗
- 2018Uncommon Filaggrin Variants Are Associated with Persistent Atopic Dermatitis in African Americans.The Journal of investigative dermatologyPubMed ↗
- 2012Epidemiologic and genetic characteristics of alopecia areata (part 2).Acta dermatovenerologica Alpina, Pannonica, et AdriaticaPubMed ↗