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Phenotype profile

diabetes mellitus

SaudiVarKB evidence summary derived from retained literature mentions.

1,985Phenotype mentions
100Publications
50Associated gene records
50Associated variant records

Associated gene records

Co-mentioned in the same publications
GeneIdentifier / contextArticlesMentions
TCF7L2HGNC:116412020
KCNJ11HGNC:62572020
SIRT1HGNC:149291717
VDRHGNC:126791616
ACEHGNC:27071313
NLRP3HGNC:164001212
STAT3HGNC:113641010
INSHGNC:60811010
TLR4HGNC:118501010
SLC30A8HGNC:203031010
FTOHGNC:246781010
ABCC8HGNC:591010
HLA-DRB1HGNC:494899
EIF2AK3HGNC:325599
FOXO1HGNC:381999
KCNQ1HGNC:629488
GCKHGNC:419588
MAFHGNC:677688
IRS1HGNC:612588
TGHGNC:1176477
PPARGHGNC:923677
MTHFRHGNC:743677
CYP2C19HGNC:262177
PCSK9HGNC:2000177
ABCA1HGNC:2977
HLA-DQB1HGNC:494477
CYP2C9HGNC:262377
TNFHGNC:1189266
BDNFHGNC:103366
APOEHGNC:61366
CD34HGNC:166266
PTENHGNC:958866
IL10HGNC:596266
GLIS3HGNC:2851066
AKT1HGNC:39166
MMP9HGNC:717666
CDKAL1HGNC:2105066
IGF2BP2HGNC:2886766
INSRHGNC:609166
GSTT1HGNC:464166
ADIPOQHGNC:1363366
HNF1AHGNC:1162166
ACE2HGNC:1355766
LPLHGNC:667755
LDLRHGNC:654755
VEGFAHGNC:1268055
JAK2HGNC:619255
FASHGNC:1192055
MC4RHGNC:693255
HHEXHGNC:490155

Associated variant records

Co-mentioned in the same publications
VariantIdentifier / contextArticlesMentions
C677TC677T55
rs7903146rs790314655
rs1544410rs154441044
rs731236rs73123644
rs7903146rs790314633
rs2228570rs222857033
rs9939609rs993960933
rs1800795rs180079533
rs4402960rs440296033
rs1801133rs180113322
rs1800896rs180089622
rs1800871rs180087122
rs1800872rs180087222
c.436delCc.436delC22
H63DH63D22
C282YC282Y22
rs662rs66222
rs1800470rs180047022
rs1333048rs133304822
rs10757278rs1075727822
rs7975232rs797523222
rs12248560rs1224856022
rs699947rs69994722
rs440960rs44096022
rs1801282rs180128222
rs2975760rs297576022
rs1501299rs150129922
rs17846866rs1784686622
-308G>A-308G>A22
rs11642841rs1164284122
rs10830963rs1083096322
rs8050136rs805013622
A8344GA8344G22
A3243GA3243G22
rs13266634rs1326663422
rs699rs69922
G972RG972R22
rs1801278rs180127822
rs12255372rs1225537222
rs4516035rs451603522
C69TC69T22
rs10811661rs1081166122
45T>G45T>G22
c.1177C>Tc.1177C>T11
p.Arg393*p.Arg393*11
c.155_166delc.155_166del11
p.Arg347Hisp.Arg347His11
c.1278C>Ac.1278C>A11
p.Tyr426*p.Tyr426*11
rs1800436rs180043611

Associated population records

Co-mentioned in the same publications
PopulationIdentifier / contextArticlesMentions
Saudi Arabia123123
Population recordCohort 24040
Saudi ArabiaCohort 22121
Population recordCohort 191818
Population recordCohort 1001818
Saudi Arabia1717
Saudi Arabia · Riyadh1616
Population record1515
Population recordCohort 11212
Saudi Arabia · Jeddah99
Population recordCohort 20077
Saudi ArabiaCohort 10077
Saudi ArabiaCohort 1977
Population recordCohort 2066
Population recordCohort 366
Population recordCohort 1055
Population recordCohort 3055
Population recordCohort 12055
Population recordCohort 40055
Population recordCohort 044
Population recordCohort 4044
Population recordCohort 5644
Population recordCohort 4544
Saudi Arabia · RiyadhCohort 244
Population recordCohort 30044
Population recordCohort 2333
Population recordCohort 433
Population recordCohort 533
Population recordCohort 5033
Population recordCohort 833
Population recordCohort 1533
Saudi Arabia · Eastern Province33
Saudi ArabiaCohort 1833
Population recordCohort 12233
Saudi ArabiaCohort 133
Saudi ArabiaCohort 433
Saudi ArabiaCohort 10233
Saudi Arabia · RiyadhCohort 38533
Saudi ArabiaCohort 25033
Population recordCohort 38433
Population recordCohort 1722
Population recordCohort 6522
Population recordCohort 13522
Saudi ArabiaCohort 122
Saudi Arabia · Riyadh22
Saudi ArabiaCohort 8722
Saudi ArabiaCohort 6022
Population recordCohort 8022
Population recordCohort 622
Population recordCohort 8222

Supporting publications

100 records
  1. 2026Type 2 Diabetes Mellitus in Saudi Arabia: Prevalence, Risk Factors, and Management Strategies: A Review.Endocrine, metabolic & immune disorders drug targets1 mentions
  2. 2026Harnessing virtual screening and MD simulations: a multistage approach to identifying potent and nontoxic agonists for protein kinase A.Molecular diversity1 mentions
  3. 2026Synthesis of (E)-3-(aryl)-1-phenylprop-2-en-1-one Chalcone Derivatives for Hyperglycemic Effect in Diabetes: In Vitro, In Vivo and In Silico Approach.Current medicinal chemistry1 mentions
  4. 2026Chronic metabolic acidosis of diabetes (CMAD): clinical features, diagnosis, and therapeutic potentials of pH correction.Minerva endocrinology1 mentions
  5. 2026Fortified Food With Withania Somnifera Modulates Glucose Metabolism in STZ-Induced Hyperglycemia in Rats.Biotechnology and applied biochemistry1 mentions
  6. 2026Anti-inflammatory and anti-diabetic role of Ashwagandha (Withania somnifera) in a type 2 diabetes mellitus mouse model: a study using histological, molecular, and pathological parameters.Protoplasma1 mentions
  7. 2026A Systematic Review on Effect of Bifidobacterium Isolated from Skin Microbiota on GLP-1 Production to Alleviate Human Ailments.Probiotics and antimicrobial proteins1 mentions
  8. 2026Computational insights into PKCθ non-synonymous SNPs: from structural changes to functional implications.Journal of biomolecular structure & dynamics1 mentions
  9. 2026Metformin-mediated modulation of epigenetic regulators in type 2 diabetes: A study on differential expression of DNMT1, TET1, OGG1, and AID genes.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
  10. 2026Prevalence of Vitamin B12 Deficiency in Patients with Type 2 Diabetes Mellitus on Metformin: A Single Retrospective Study in a Tertiary Health Care Center Experience.Current diabetes reviews1 mentions
  11. 2026Journey through the gut-inflammation axis in polycystic ovary syndrome: the microbiota's role in shaping inflammatory pathways.Molecular and cellular biochemistry1 mentions
  12. 2026Protective role of dibenzylideneacetone derivative (MBK2) against diabetic pathophysiology via PTGS2-PGE2 signaling modulation and redox homeostasis.Biochemical pharmacology1 mentions
  13. 2026Carvacrol alleviates diabetic cardiomyopathy in rats: Targeting Cuproptosis pathway.Toxicology and applied pharmacology1 mentions
  14. 2026Characterization of monogenic diabetes among Sudanese children: a multi-center experience from a population with high consanguinity.Journal of pediatric endocrinology & metabolism : JPEM1 mentions
  15. 2026Advances in Wound Healing Strategies for Diabetic Foot Ulcers: From Conventional to Regenerative Therapies.Current diabetes reviews1 mentions
  16. 2026GADA as a biomarker for type 1 diabetes.Clinica chimica acta; international journal of clinical chemistry1 mentions
  17. 2026Circular RNAs as Biomarkers and Therapeutic Targets in Diabetic Cardiovascular Complications.Endocrinology, diabetes & metabolism1 mentions
  18. 2026Unlocking potentials of a prenylated flavonoid: Xanthohumol's role in combating inflammatory conditions and Rhematic diseases.Cytokine1 mentions
  19. 2026Isobavachalcone reduces blood glucose and promotes muscle development via dipeptidyl peptidase-4 inhibition.International journal of biological macromolecules1 mentions
  20. 2026Three-dimensional models for type 2 diabetes study.Diabetology international1 mentions
  21. 2026Targeting the underlying immune mechanism of diabetes-induced myocardial dysfunction via modulation of SIRT-3/p53/TIGAR/PFKFB-3 and SIRT-3/NF-κB signaling pathways as a potential controlling strategy.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie1 mentions
  22. 2026Development and optimization of the hypoglycemic activity of an α-glucosidase inhibitory protein from a UV-induced mutant strain of Streptomyces griseorubens.Protein expression and purification1 mentions
  23. 2026Effects of Brassica juncea Seed Extract on Diabetes-Related Gene Expression Profiling of Pancreatic β-Cells in a Rat Model: Relevance to Environmental and Health Safety.Journal of the American Nutrition Association1 mentions
  24. 2026GDF-15 as an integrative cardiometabolic biomarker.Clinica chimica acta; international journal of clinical chemistry1 mentions
  25. 2026Reduced plasma epidermal growth factor levels reflect poor glycaemic status in type 2 diabetes.Endocrine connections1 mentions
  26. 2026Mitigation of Metabolic Diseases Through Personalized Nutrition: A Critical In-Depth Review.Food science & nutrition1 mentions
  27. 2026Analysis of Risk Factors and Assessment of miRNA-122 as a Novel Biomarker for Colon Cancer in Egyptian Patients.Asian Pacific journal of cancer prevention : APJCP1 mentions
  28. 2026Identification of Additional Cases of Severe Neonatal GABA-Transaminase Deficiency.JIMD reports1 mentions
  29. 2026Post-Myocardial Infarction Prognostic Factors and Mortality in the Gulf Region: A Systematic Review and Meta-Analysis.Current cardiology reviews1 mentions
  30. 2026RNA-Binding Proteins in Adipose Biology: From Mechanistic Understanding to Therapeutic Opportunities.International journal of molecular sciences1 mentions
  31. 2026Harnessing Phytochemicals and Nanotechnology Synergy for Molecular, Epigenetic, and Microbiota-Driven Regulation in Type 2 Diabetes Mellitus.Pharmaceutics1 mentions
  32. 2026Prevalence of Carbapenem-Resistant Enterobacteriaceae in Intensive Care Units in Saudi Arabia: A 10-Year Systematic Review.Saudi medical journal1 mentions
  33. 2026National Heart Center/Saudi Heart Association 2025 Guidelines for Cardiovascular Diseases Prevention and Risk Assessment.Saudi medical journal1 mentions
  34. 2026Dictyota ciliolata ameliorates hyperglycemia, oxidative stress, and inflammation via modulation of metabolic and signaling pathways in diabetic rats.Tissue & cell1 mentions
  35. 2026Nano-liposomal berberine and vildagliptin combination: A novel therapeutic approach against oxidative stress, inflammation, autophagy dysregulation, and fibrosis in diabetic nephropathy.Tissue & cell1 mentions
  36. 2026Bukiniczia cabulica (Boiss.) Lincz. ameliorate diabetes-induced neuropathy: analgesic, anti-diabetic and anti-neuropathic using enzyme inhibitory, molecular docking and in-vivo studies.Inflammopharmacology1 mentions
  37. 2026Clinical biomarkers and biosensors for early detection of metabolic dysfunction-associated steatohepatitis (MASH): a translational perspective.Frontiers in bioengineering and biotechnology1 mentions
  38. 2026Epigenetic regulation by HDAC11-driven STAT3 activation promotes pro-inflammatory cytokine production and endothelial dysfunction upon bacterial infection in diabetes.Cell communication and signaling : CCS1 mentions
  39. 2026Prognostic Impact of New-Onset Atrial Fibrillation After Cardiac Arrest: Observations From a Federated Research Network.Journal of cardiovascular electrophysiology1 mentions
  40. 2026Delphi Consensus on the Use of Fenofibrate as Systemic Therapy for the Prevention of Diabetic Retinopathy Progression.Journal of diabetes1 mentions
  41. 2026Advancing the diagnosis of cardiac electrophysiological disorders in diabetes: integrating clinical, imaging, and molecular insights.Frontiers in medicine1 mentions
  42. 2026Impact of a 12-week calisthenic exercise regimen on glycaemic regulation and cardiovascular endurance in individuals with type 2 diabetes Mellitus. A randomized controlled trail.Complementary therapies in medicine1 mentions
  43. 2026Advancing Life Sciences and Biotechnology in Saudi Arabia: A Comprehensive Overview of the Saudi Biobank Project Study Design and Aspirations.Journal of epidemiology and global health1 mentions
  44. 2026Trimetazidine is associated with suppression of endoplasmic reticulum stress-mediated NLRP3 inflammasome activation in type 1 diabetes-induced liver damage in rats.European journal of medical research1 mentions
  45. 2026Human infections caused by pathogenic Burkholderia: current clinical challenges and future perspectives.Infection1 mentions
  46. 2026Integrating trust into artificial intelligence for medicine: using diabetes as the exemplar disease.Journal of translational medicine1 mentions
  47. 2026Pregnancy-Triggered Vaso-Occlusive Crises in Hemoglobin SE Disease Complicated by Glucose-6-Phosphate Dehydrogenase Deficiency: A Case Report.Cureus1 mentions
  48. 2026Prevalence and Recovery of Euthyroid Sick Syndrome in Pediatric Diabetic Ketoacidosis: A Retrospective Cohort Study.Children (Basel, Switzerland)1 mentions
  49. 2026Cross-Cultural Nutritional Epigenomics: Diet and Microbiome Interactions Shaping Type 2 Diabetes in Arab and Western Populations.Nutrients1 mentions
  50. 2026Oral Immunization with the C488A Live-Attenuated Mutant of Coxsackievirus B4E2 (CVB4E2) Induces Potent Immune Response and Protects Balb/c Mice Against Lethal Infection.Viruses1 mentions
  51. 2026Tirzepatide ameliorates type 2 diabetes-associated male reproductive dysfunction via modulation of the Nrf2/Keap1 pathway.Toxicology research1 mentions
  52. 2026Exploring the anti-diabetic potential of bis-Schiff bases of ibuprofen: insights into the in vitro, molecular docking and density functional theory analyses.RSC advances1 mentions
  53. 2026Mesenchymal stem cell-conditioned media alleviates diabetic cardiomyopathy by modulating glycemic control, oxidative stress-induced injury and inflammation regulation.Journal of diabetes and metabolic disorders1 mentions
  54. 2026The long-term impact of early HbA1c control on nephropathy, neuropathy, and retinopathy in type 2 diabetes: Findings from a large UK observational study.Journal of diabetes and its complications1 mentions
  55. 2026Functional Hemispherectomy for Rasmussen Encephalitis in a Patient with Systemic Lupus Erythematosus and Type 1 Diabetes Mellitus: A Case Report.International medical case reports journal1 mentions
  56. 2026KCNJ11 (p.Arg192Cys)-associated MODY13 with coexisting autoimmunity in a child, a case report.BMC pediatrics1 mentions
  57. 2026The Significance of miRNA-375 in β-cell Function and Autoimmune Destruction in Type 1 Diabetes Mellitus: A Review Article.Reviews on recent clinical trials1 mentions
  58. 2026Integrating the Glycemia Risk Index Into Clinical Practice and Research: A Consensus Report.Journal of diabetes science and technology1 mentions
  59. 2026Neonatal Diabetes Mellitus Due to Homozygous ZNF808 Mutation Associated With Skeletal Anomalies: A Novel Presentation of Pancreatic Agenesis-3.Cureus1 mentions
  60. 2026Dapagliflozin Loaded Bilosomes Gel for Transdermal Delivery: Formulation, Optimization, Physicochemical Characterization, and In Vivo Evaluation.AAPS PharmSciTech1 mentions
  61. 2026Diabetes Mellitus as an Integrated Microbiome, Immune, and Metabolic Disorder with Clinical Implications for Multisystem Complications and Public Health.Journal of clinical medicine1 mentions
  62. 2026Exploring the Epigenetic Mechanisms Underlying Chronic Diseases: A Comprehensive Review.Current gene therapy1 mentions
  63. 2026Glycohypoxia: a hypothesis linking chronic hyperglycemia to functional hypoxia and diabetic complications in type 2 diabetes.Medical gas research1 mentions
  64. 2026Association of NLRP3 Inflammasome rs10754558 Polymorphism with Type 2 Diabetes Mellitus and Its Complications: Clinical and Bioinformatics Study.Diabetes, metabolic syndrome and obesity : targets and therapy1 mentions
  65. 2026Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities.Cell metabolism1 mentions
  66. 2026The multifaceted nature of Friedreich ataxia: strategies for comprehensive patient care.Neurodegenerative disease management1 mentions
  67. 2026Synthesis, characterization, blood biochemical parameters evaluation and antidiabetic potential of thiobarbiturate derivatives.Pakistan journal of pharmaceutical sciences1 mentions
  68. 2026Delonix regia flower extract protects against diabetic cardiac remodeling via modulating eNOS/NO/cGMP and NF-κB/iNOS/TNF-α trajectories.The Journal of pharmacy and pharmacology1 mentions
  69. 2026Multi-Omics and Machine Learning-Driven Discovery of ABCC8 (SUR1) for Diabetes Mellitus: Integrating Molecular Insights on Nigella sativa Bioactives and Sulfonylurea.Chemical biology & drug design1 mentions
  70. 2026Integrated Computational Analysis Reveals Structurally Destabilizing Missense Variants in the PDX1 Transcription Factor.Genes1 mentions
  71. 2026Clinical Outcomes with the Use of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor Among Patients with Diabetes Mellitus and COVID-19: A Systematic Review of Observational Studies.Journal of clinical medicine1 mentions
  72. 2026Acrylamide Exposure Exacerbates Type 2 Diabetes-Induced Neurotoxicity: An Integrated Neurobehavioral and Molecular Investigation.Life (Basel, Switzerland)1 mentions
  73. 2026Explainable Meta-Learning Ensemble Framework for Predicting Insulin Dose Adjustments in Diabetic Patients: A Comparative Machine Learning Approach with SHAP-Based Clinical Interpretability.Medicina (Kaunas, Lithuania)1 mentions
  74. 2026Traditional cardiovascular risk factors and their association with atherosclerotic cardiovascular disease in homozygous familial hypercholesterolemia: A cross-sectional analysis from the HICC registry.Atherosclerosis1 mentions
  75. 2026Harnessing mangroves for epigenetic therapies.Natural product research1 mentions
  76. 2026Association Between Genotype and Plasma Levels of EPCR in Type 2 Diabetes Mellitus in Jazan Region, Saudi Arabia: A Case-Control Study.International journal of general medicine1 mentions
  77. 2026Association of P2Y12 G52T genetic polymorphism with recurrent thromboembolic events in stroke and myocardial infarction patients on clopidogrel therapy: a prospective observational study.Scientific reports1 mentions
  78. 2026TGF-β1 Gene Polymorphisms in Saudi Patients With Type 2 Diabetes With or Without Diabetic Nephropathy.International journal of endocrinology1 mentions
  79. 2026Mayer-Rokitansky-Küster-Hauser Syndrome Associated With Diabetes Mellitus and Renal Anomalies in an Adolescent Girl: A Rare Case Report.AACE endocrinology and diabetes1 mentions
  80. 2026Erdheim-Chester Disease: A Rare Presentation With Atrial Flutter and Severe Sinus Node Dysfunction.JACC. Case reports1 mentions
  81. 2026Network pharmacology and molecular docking reveal PPARγ-directed antidiabetic phytochemical compounds of Momordica charantia.In silico pharmacology1 mentions
  82. 2026Identification of novel genomic variants in diabetic nephropathy patients using whole-exome sequencing: a pilot investigation.Frontiers in endocrinology1 mentions
  83. 2026Fam-trastuzumab deruxtecan in a patient with metastatic human epidermal growth factor receptor 2-positive breast cancer and pre-existing cardiac failure: a case report.AME case reports1 mentions
  84. 2026The prevalence of diabetic retinopathy in type-2 diabetes in Pakistan: a systematic review and meta-analysis.Frontiers in clinical diabetes and healthcare1 mentions
  85. 2026Effect of methanolic extract of Salix babylonica on biochemical parameters and gene expression in streptozotocin induced diabetic rat model.Fitoterapia1 mentions
  86. 2026Deciphering enzyme inhibition of thiazole assemblies for diabetes management via molecular docking, dynamic simulation, DFT and kinetic study: A computational therapeutic strategy.Computational biology and chemistry1 mentions
  87. 2026Antidiabetic Activity of Phenolic-Rich Extracts From Cistus albidus (L.) in Alloxan-Induced Diabetic Rats: In Vitro, In Vivo, and In Silico Investigations.Food science & nutrition1 mentions
  88. 2026Self-Management Interventions in Young Adults (18-30 Years) With Type 1 Diabetes, Sickle Cell Disease, and Inflammatory Bowel Disease: A Scoping Review.Chronic diseases and translational medicine1 mentions
  89. 2026Calcium Carbonate-Stabilized Nano-Caffeine Emulsion Attenuates Diabetic Cardiomyopathy via Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Pathways in Type 2 Diabetic Rats with HPLC-Quantified Cardiac Caffeine Levels.International journal of nanomedicine1 mentions
  90. 2026Detection of New Delhi metallo-β-lactamase (blaNDM) and oxacillinase (blaOXA-48) genes among carbapenem-resistant Enterobacteriaceae (CRE) in Jazan Region, Saudi Arabia.Scientific reports1 mentions
  91. 2026Modulation of the serotonergic system restores oxidative balance and gene expression in the brain and heart of rats with obesity induced by overnutrition.Frontiers in physiology1 mentions
  92. 2026Medicinal Plants and the Gastrointestinal Microbiota in Chronic Diseases Modulation: A Structured Mechanistic and Translational Review.Current microbiology1 mentions
  93. 2026Phenotype-Specific Mortality Outcomes with Dipeptidyl Peptidase-4 Inhibitors in Heart Failure and Diabetes: Real-World Evidence from a Retrospective Single-Center Cohort Study.Journal of clinical medicine1 mentions
  94. 2026Cardioprotective effects of 3-N-Butylphthalide in diabetic cardiomyopathy: focus on balanced mitochondrial dynamics and pyroptosis pathways.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology1 mentions
  95. 2026Targeting Nrf2/HO-1, NF-κB, and Apoptotic Pathways: Mechanistic Evaluation of Phlorizin Nanoparticles in Diabetic Renal Injury.Clinical and experimental pharmacology & physiology1 mentions
  96. 2026High prevalence of poly cystic ovary syndrome among young Saudi medical students: an observational cross-sectional study.Frontiers in medicine1 mentions
  97. 2026Blood viscosity in clinical practice: A critical review of diagnostic utility, therapeutic implications, and evidence gaps.Clinical hemorheology and microcirculation1 mentions
  98. 2026X-Linked immune dysregulation, polyendocrinopathy, and enteropathy (IPEX) syndrome with concurrent membranous and IgA nephropathy: a case report.BMC nephrology1 mentions
  99. 2026Irisin mitigates diabetic cardiac damage and is associated with improved redox status and reduced p53/VCAM-1 mRNA expression in STZ-treated rats.Archives of biochemistry and biophysics1 mentions
  100. 2026Assessment of antibiotic prophylaxis post cardiac implantable electronic device implantation: a retrospective cohort study.BMC infectious diseases1 mentions