V600E
V600E · SaudiVarKB evidence summary derived from retained literature mentions.
34Variant mentions
34Publications
19Associated gene records
2Associated phenotype records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| BRAF | HGNC:1097 | 34 | 34 |
| NRAS | HGNC:7989 | 5 | 5 |
| KRAS | HGNC:6407 | 4 | 4 |
| TERT | HGNC:11730 | 4 | 4 |
| TP53 | HGNC:11998 | 3 | 3 |
| RET | HGNC:9967 | 2 | 2 |
| HRAS | HGNC:5173 | 2 | 2 |
| NTRK1 | HGNC:8031 | 1 | 1 |
| PTEN | HGNC:9588 | 1 | 1 |
| GNAS | HGNC:4392 | 1 | 1 |
| MAP2K1 | HGNC:6840 | 1 | 1 |
| EIF1AX | HGNC:3250 | 1 | 1 |
| MLH1 | HGNC:7127 | 1 | 1 |
| PIK3CA | HGNC:8975 | 1 | 1 |
| TPO | HGNC:12015 | 1 | 1 |
| PDGFRA | HGNC:8803 | 1 | 1 |
| SAMMSON | HGNC:49644 | 1 | 1 |
| BANCR | HGNC:43877 | 1 | 1 |
| RMEL3 | HGNC:53975 | 1 | 1 |
Associated phenotype records
Co-mentioned in the same publications| Phenotype | Identifier / context | Articles | Mentions |
|---|---|---|---|
| thyroid cancer | — | 18 | 18 |
| colorectal cancer | — | 2 | 2 |
Associated population records
Co-mentioned in the same publications| Population | Identifier / context | Articles | Mentions |
|---|---|---|---|
| Saudi Arabia | — | 3 | 3 |
| Population record | Cohort 18 | 1 | 1 |
| Population record | Cohort 2 | 1 | 1 |
| Population record | Cohort 50 | 1 | 1 |
| Population record | Cohort 200 | 1 | 1 |
| Population record | Cohort 30 | 1 | 1 |
| Population record | Cohort 210 | 1 | 1 |
| Population record | Cohort 110 | 1 | 1 |
| Population record | Cohort 122 | 1 | 1 |
| Population record | Cohort 90 | 1 | 1 |
| Saudi Arabia | Cohort 9 | 1 | 1 |
| Saudi Arabia | Cohort 770 | 1 | 1 |
| Saudi Arabia | Cohort 204 | 1 | 1 |
| Population record | Cohort 822 | 1 | 1 |
| Population record | Cohort 54 | 1 | 1 |
| Population record | Cohort 550 | 1 | 1 |
| Saudi Arabia | Cohort 210 | 1 | 1 |
| Population record | Cohort 191 | 1 | 1 |
| Population record | Cohort 316 | 1 | 1 |
| Population record | Cohort 16,170 | 1 | 1 |
Supporting publications
34 records- 2026Primary Pulmonary Ameloblastoma: First Case Series With Clinicopathologic and Genomic Analysis.The American journal of surgical pathology1 mentions
- 2026Recurrent primary hyperparathyroidism with ipsilateral multifocal papillary thyroid carcinoma of classical, warthin-like, and follicular variants harboring distinct BRAF and NRAS mutations: a rare case report.World journal of surgical oncology1 mentions
- 2025Non-coding RNAs in BRAF-mutant melanoma: targets, indicators, and therapeutic potential.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2025Advances in genetic and molecular insights into thyroid disorders: Implications for diagnosis, prognosis, and personalized treatment.Saudi medical journal1 mentions
- 2025Eco-conscious AQbD-guided stability-indicating RP-UPLC method for analysing Tovorafenib in bulk and dosage forms.Scientific reports1 mentions
- 2025No prognostic or molecular disparity between synchronous and metachronous metastases in differentiated thyroid cancer: insight from middle eastern cohort.International journal of surgery (London, England)1 mentions
- 2024The Prevalence and Prognostic Implications of BRAF K601E Mutations in Thyroid Neoplasms: A Systematic Review and Meta-Analysis.Head & neck1 mentions
- 2024Clinical and Histopathological Features of Thyroid Cancer with TERT Promoter Molecular Alterations in Isolation Versus with Concurrent Molecular Alterations: A Multicenter Retrospective Study.Cancers1 mentions
- 2024Exploring somatic mutations in BRAF, KRAS, and NRAS as therapeutic targets in Saudi colorectal cancer patients through massive parallel sequencing and variant classification.Frontiers in pharmacology1 mentions
- 2023FDG PET/CT Prognostic Markers in Patients with Advanced Melanoma Treated with Ipilimumab and Nivolumab.Radiology1 mentions
- 2023Metastatic papillary thyroid carcinoma in pleural effusion: a case report and review of the literature.Journal of medical case reports1 mentions
- 2023The Impact of BRAF V600E Mutation Allele Frequency on the Histopathological Characteristics of Thyroid Cancer.Cancers1 mentions
- 2022TERT Promoter Mutations Are an Independent Predictor of Distant Metastasis in Middle Eastern Papillary Thyroid Microcarcinoma.Frontiers in endocrinology1 mentions
- 2022Coexisting Molecular Alterations Increase the Risk of Malignancy in Thyroid Nodules with Copy Number Alterations.Cancers1 mentions
- 2021Cerebellar pleomorphic xanthoastrocytoma in the setting of neurofibromatosis type-I: Does it portend a different prognosis? A case report and systematic review.Clinical neurology and neurosurgery1 mentions
- 2020Ameloblastic fibrosarcoma: clinicopathological and molecular analysis of seven cases highlighting frequent BRAF and occasional NRAS mutations.Histopathology1 mentions
- 2020BRAF and KRAS mutations in papillary thyroid carcinoma in the United Arab Emirates.PloS one1 mentions
- 2020Oncogene mutational analysis in imatinib naive population of gastrointestinal stromal tumor patients.Cellular and molecular biology (Noisy-le-Grand, France)1 mentions
- 2019ACTH-Secreting Neuroendocrine Carcinoma of the Cecum: Case Report and Review of the Literature.Clinical colorectal cancer1 mentions
- 2019BRAF gene mutations in synchronous papillary thyroid carcinoma and Langerhans cell histiocytosis co-existing in the thyroid gland: a case report and literature review.BMC cancer1 mentions
- 2019Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo.Nature communications1 mentions
- 2017Erdheim-Chester Disease with No Skeletal Bone Involvement and Massive Weight Loss.Case reports in hematology1 mentions
- 2016TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer.Oncogene1 mentions
- 2016IL-12 immunotherapy of Braf(V600E)-induced papillary thyroid cancer in a mouse model.Laboratory investigation; a journal of technical methods and pathology1 mentions
- 2016Uncommon TERT Promoter Mutations in Pediatric Thyroid Cancer.Thyroid : official journal of the American Thyroid Association1 mentions
- 2016BRAF and MAP2K1 mutations in Langerhans cell histiocytosis: a study of 50 cases.Human pathology1 mentions
- 2016Classical V600E and other non-hotspot BRAF mutations in adult differentiated thyroid cancer.Journal of translational medicine1 mentions
- 2015Diagnostic value of fine needle aspiration BRAF(V600E) mutation analysis in papillary thyroid cancer: a systematic review and meta-analysis.Human pathology1 mentions
- 2014Concomitant RAS, RET/PTC, or BRAF mutations in advanced stage of papillary thyroid carcinoma.Thyroid : official journal of the American Thyroid Association1 mentions
- 2014A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma.Molecular cancer1 mentions
- 2014Comparing BRAF mutation status in matched primary and metastatic cutaneous melanomas: implications on optimized targeted therapy.Experimental and molecular pathology1 mentions
- 2013Pancreas as delayed site of metastasis from papillary thyroid carcinoma.Case reports in gastrointestinal medicine1 mentions
- 2012Pancreatic metastasis arising from a BRAF(V600E)-positive papillary thyroid cancer: the role of endoscopic ultrasound-guided biopsy and response to sorafenib therapy.Thyroid : official journal of the American Thyroid Association1 mentions
- 2009Aberrant BRAF splicing as an alternative mechanism for oncogenic B-Raf activation in thyroid carcinoma.The Journal of pathology1 mentions