CD34
HGNC:1662 · 52 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD34 | “Tumor cells were GLUT-1 positive and negative for S100, GFAP, pan-cytokeratin, SMA, WT-1, CD31, CD34, STAT6, β-catenin, and HMB-45, with Ki-67 nuclear staining of 10-15% of cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Initially excised under the impression of a lipoma, the lesion's histopathology revealed neural origin features with strong S100 and CD34 positivity.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “We report an uterine sarcoma with a FGFR1::TACC1 fusion, the third reported case in the literature, exhibiting epithelioid morphology not previously documented and negativity for S100 and CD34 immunohistochemistry (IHC).” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Here, an integrated, multi-compartment transcriptomic analysis of publicly available microarray datasets was performed, spanning bone marrow (BM) CD34+ progenitors, peripheral blood (PB) CD34+ progenitors, and whole blood from PV patients and healthy controls, with independent validation in neutrophils.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Fucosylation enhances CD34⁺ hematopoietic stem cell homing and longevity via E-selectin-mediated adhesion and signaling.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “A Combination of Plerixafor and Filgrasting Promotes Successful CD34+ Cell Collection for CRISPR/Cas9 Therapy in Sickle Cell Disease Patients With Insufficient Response to Plerixafor Alone.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Markers associated with stromal, epithelial, and endothelial phenotypes (vimentin, α-SMA, desmin, CD117, CD105, CD34, and CD31) were evaluated in kidneys from five healthy animals.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Peripherally mobilized CD34 stem cells targeting 10 × 106 /kg of recipient weight were used.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Tumor cells were reactive for STAT6, BCL2, and CD99, while CD34 was negative.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “CD34 serves as an intrinsic innate immune guardrail protecting stem cells from replicating retroviruses.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Distinct Phenotypic and Molecular Characteristics of CD34- and CD34+ Hematopoietic Stem/Progenitor Cell Subsets in Cord Blood and Bone Marrow Samples: Implications for Clinical Applications.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “In one of them, erythroid proliferation and differentiation from peripheral blood CD34+ cells were studied by flow cytometry, and RPL26 expression by quantitative reverse transcription polymerase chain reaction and immunoblotting.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Based on different T-cell depletion (TCD) approaches, four categories were identified: (1) TCRαβ+/CD19+-depletion (43.8%); (2) T-repleted with post-transplant Cyclophosphamide (PTCy, 34.0%); (3) In-vivo T-depletion with ATG/alemtuzumab (14.8%); (4) CD34+ positive selection (7.4%).” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “The median infused CD34 dose was 13.7 (5.07-25.8), respectively.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “A strong significant correlation in treated rats between fibrosis score and CD34 and FGF23 gene expression.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “METHODS: Hybrid NPs were synthesized, characterized, and assessed for their cytotoxicity against Kasumi-1, HL-60, and THP-1 in comparison to normal primary bone marrow CD34+ cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Bone marrow was hypercellular with 71% blasts, and flow cytometry showed myeloid markers including CD11c, CD33, CD34, and CD45 among others indicating AML with monocytic differentiation.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “We investigated whether varying durations of culture resting times impact the engraftment efficiency of human CD34+ HSPCs edited at the BCL11A enhancer, a key regulator in the expression of fetal hemoglobin.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “The RNA sequencing (RNA-seq) data used in this study was obtained from the Gene Expression Omnibus (GEO) database (accession number GSE104406), which was collected from Fluorescent Activated Cell Sorting (FACS) of human bone marrow derived human hematopoietic stem cells (BM-HSCs) (Lineage-, CD34+, CD38-) young (18-30 years old) and aged (65-75 years old) donors who had no known hematological malignancy, with 10 biological replicates per group.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “However, immunophenotypically they had essentially a null phenotype, with only two tumors staining partially for CD34 and smooth muscle actin.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Single-cell transcriptional profile of CD34+ hematopoietic progenitor cells from del(5q) myelodysplastic syndromes and impact of lenalidomide.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Cell surface protein expression analysis revealed upregulation of CD45, CD99, CD34, HLA-DR, CD38, CD13, CD33, MPO, CD15 and CD117 in AML patients.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Then, for the ZOIUUTW distribution, the CD34+ data involving cancer patients are analyzed to show the flexibility of the model in characterizing inflation at both endpoints of the unit interval.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “The healing of diabetic wounds was assessed by measuring wound closure, oxidative stress markers, immunohistochemical staining of NF-βB, VEGF, CD34, CD45, Ki-67, and eNOS, gene expression of MMP-9, TGF-β1, EGF-b1, FGF, and Col1A1, protein levels of TNFα, IL-1β, IL6, Ang II, and HIF-1α by ELISA assay, and histological examination with H & E and Masson's trichrome.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “CD34+ cells were isolated from human umbilical cord blood using magnetic activated cell sorting and differentiated into MCs with rhIL-6 and rhSCF supplementation for 6-8 weeks.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Here, we report that upregulation of PGC-1α by infection with a lentivirus expressing PGC-1α or by the small-molecule PGC-1α agonist ZLN005 in human primary erythroid progenitor CD34+ cells induces both fetal γ-globin mRNA and protein expression as well as the percentage of HbF-positive cell (F cells) without significantly affecting cell proliferation and differentiation.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “MiR-18a-5p was inversely correlated with CFU-Hill's colonies, CD34+, CD34+CD133+ cells, and positively with IL-10, C-reactive protein, vascular endothelial growth factor-D (VEGF-D), and thrombomodulin.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Expression levels of TCM homing receptors, CD34 and GlyCAM-1, were also significantly upregulated in the lung tissues of OVA-sensitized mice, which may facilitate the increased TCM infiltration into inflamed lungs.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “In addition there was no statistically significant association of mutRAS gene of AML patients with several prognostic markers including age, gender, karyotyping, CD34 positivity, cytogenetic abnormalities, total leukocyte count, white blood cell count and French-American-British (FAB) classification.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Giant cell fibroblastoma (GCF) presented as painless swelling in the trunk, positive for CD34 with PTEN gene mutation.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “LSCs belong to the primitive population; CD34+CD38-Lin-, which does not distinguish normal hematopoietic stem cells (HSC) from CML LSCs.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Immunohistochemistry showed co-expression of S100 protein, CD34 and TRK.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “MiR-126-5p was positively correlated with CXCR1/2, and with HbA1c whilst negatively correlated with circulating endothelial progenitor cells (CD34+CD133+CD45dim) and fibronectin adhesion assay in a combined group of T1DM patients and HCs; p = 0.028 p = 0.049 p = 0.035 p = 0.047 and p = 0.004 respectively.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Flow-cytometric analysis for the MSC surface-markers CD105, CD73, CD166, CD90, CD34, CD45 and HLA-DR was performed.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “METHODS AND RESULTS: We successfully isolated CD34+ cells from peripheral blood of β-thalassemia patients with IVS-1-110 mutation.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Immunohistochemical (IHC) markers used included CD34 expression in all cases, Bcl-2 expression in 10/11, CD99 in 9/9 and Vimentin in 4/4.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “The most important thyroid stem cell's markers are: stem cell antigen 1 (SCA-1), octamer-binding transcription 4 (OCT-4), p63, CD34+ CD45-, paired box gene 8 (PAX-8), thyroid transcription factor 1 (TTF-1), thyroid transcription factor 2 (TTF-2), hematopoietically expressed homeobox protein HHEX, the transcription factor GATA-4, hepatocyte nuclear factor 4-α (HNF-4-α) and homeobox transcription factor Nanog (hNanog).” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Interestingly other functional markers were also shown to be reduced in ko macrophages in comparison to wt mice; the expression of CD115, which is a receptor for M-CSF, and CD34, a stem/progenitor cell marker, suggesting global regulation of gene expression by MKP-2.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “These tumors are characterized by expression of CD117 and CD34 antigens and activating mutations in the KIT and PDGFRA genes.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “The synergistic effects of saxagliptin and metformin on CD34+ endothelial progenitor cells in early type 2 diabetes patients: a randomized clinical trial.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “We have shown that metformin improves angiogenesis via affecting expression of growth factors/angiogenic inhibitors in CD34⁺ cells under hyperglycemia-hypoxia.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “ANTXR1 was expressed at mRNA and protein levels in erythroid progenitors derived from induced pluripotent stem cells (iPSCs) and CD34+ cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Metformin improves the angiogenic potential of human CD34⁺ cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “In normal CD34+ cells, RPL27A knockdown preferentially blocked erythroid proliferation and differentiation.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “The mean value of the peripheral CD34+ cells infused was 9.19 × 10 (6) /kg recipient weight.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Immunophenotypic analysis showed that the neoplastic cells were positive for CD4, CD123, TCL-1, and HLA-DR and were negative for CD3, CD8, CD13, CD19, CD34, and myeloperoxidase.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “The diagnosis was GIST, confirmed by immunohistochemical expression of CD117, CD34, and Bcl-2.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “Sensitive detection of pre-existing BCR-ABL kinase domain mutations in CD34+ cells of newly diagnosed chronic-phase chronic myeloid leukemia patients is associated with imatinib resistance: implications in the post-imatinib era.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “The proliferation was immunoreactive for HMB-45, S-100 and melan-A, and non-immunoreactive for CD34, smooth muscle actin, and AE1/AE3.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “The median CD34 cell dose was 8.3 x 10(6)/kg.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “There were significant correlations between the number of blood vessels expressing the panendothelial marker CD34 and the numbers of blood vessels expressing HIF-1alpha (r = 0.554; p = 0.026), Ang-2 (r = 0.830; p<0.001) and VEGF (r = 0.743; p = 0.001).” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “The spindle cells are positive for CD34, and Vimentin and negative for S100.” | 0.98 | hgnc_dict_v1 |