Central Province
Saudi Arabia · 1 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| population | Saudi Arabia, Central Province | “Clinical Pharmacogenomic Variants Among the Saudi Population and Their Impact on Drug Response: A Review of Saudi-Based Evidence. However, the Saudi Arabian population, which had distinctive characteristics and high rates of marriage between relatives, remains underrepresented in global dosing algorithms. This systematic review and meta-analysis synthesized quantitative evidence from 16 studies encompassing 4,111 Saudi Arabian participants to examine the clinical impact of pharmacogenomic variants on drug efficacy, toxicity, and dosing requirements. Significant statistical heterogeneity was observed, particularly within warfarin studies (I2 > 90%), which subgroup analysis suggested that geographical differences between the Eastern and Central provinces contributed to this variation. These findings indicate that the standard dosing regimens are suboptimal for a significant proportion of the Saudi population.” | 0.95 | saudi_context_rules_v1 |