EGFR
HGNC:3236 · 241 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | EGFR | “Molecular docking and MM-GBSA binding free energy analyses against EGFR, VEGFR-1, and VEGFR-2 further supported the experimental findings.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Multitargeted comparative evaluation suggests 2-Aoeobenoxmide shows favourable in silico binding compared to Tucatinib against ERα, HER2, AKT1, EGFR, and PIK3CA in breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Molecular docking simulations revealed strong binding affinities of simvastatin against key cancer targets EGFR, CA9, and GSK3β (ΔG: -7.5 to -8.7 kcal mol-1), providing a mechanistic rationale for its repurposing.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Protein-protein interaction analysis identified ten hub genes, including AKT1, STAT3, EGFR, and MMP9, representing highly connected nodes within the predicted interaction network.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Network pharmacology and molecular docking identified AP9 as a lead chemical with high affinity for hub proteins: as AKT1, EGFR, ESR1, HIF1A, MTOR, and PARP1, implying an involvement in neurodegenerative disease pathways.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Development of novel chalcone-based quinazoline derivatives as dual VEGFR-2 and EGFR inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Quinoxaline-based scaffolds as dual VEGFR-2/EGFR kinase inhibitors and apoptotic inducers: Design, synthesis, anticancer evaluation, and in silico study.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Design and synthesis of novel isatin-isoniazidhydrazone hybrid-based 1,2,3-triazoles as dual EGFR/PARP-1 inhibitors and apoptosis inducers in breast cancer cells.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “A multi-stage computational pipeline for repurposing FDA-approved drugs: application to EGFR C797S-mutant NSCLC.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “EXPERT OPINION: Small-molecule VEGFR-2 inhibitors have minimal selectivity and cause fatigue, anorexia, hypertension, hemorrhage, and bleeding due to their affinity for PDGF, EGFR, and RAF, which is conserved in many tyrosine kinases.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Specifically, we discuss the critical components of CAR-T design, including antigen selection (e.g., HER2, MUC1, and EGFR), CAR structure optimisation with intracellular signalling domains, and genetic engineering techniques like CRISPR and TALENs.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “RESULT: Pyrimidine-based EGFR TKIs, which have emerged as an efficient structural class, possess potent inhibition with improved pharmacokinetic and pharmacodynamic characteristics.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “A cross-comparison of targets related to compounds and diseases revealed nine common genes, among which three central genes TP53, CASP8, and EGFR were identified using protein-protein interaction (PPI) network analysis.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “EGFR as a biomarker in colorectal Cancer: An electrochemical biosensing approach.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Drug repurposing strategy to identify the putative leads against the Epidermal growth factor receptor (EGFR) from the USFDA-approved drug pool: Investigating the utility as an anticancer agent.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “CEACAM5 expression did not significantly correlate with tumor stage, PD-L1 expression, tumor mutation burden, and EGFR or KRAS mutations.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Six patients had EGFR exon 19 deletions and two had EML4-ALK fusions.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Cross-referencing polyphenol-associated targets with GBM-related genes identified 13 common targets (e.g., PTGS2, EGFR, ESR1, MMP9).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Integrating transcriptomics with disease-gene network and identification of EGFR kinase target: inhibitor discovery through virtual screening of natural compounds for brain cancer therapy.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “PROTACs can eliminate oncogenic proteins like EGFR, STAT3, c-MYC, and anti-apoptotic regulators by hijacking the ubiquitin-proteasome system, many of which are essential for OSCC pathophysiology and are considered undruggable.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The epidermal growth factor receptor (EGFR) stands as a cornerstone therapeutic target in oncology, particularly non-small cell lung cancer (NSCLC), where it drives tumor proliferation amid a saturated field of inhibitors and analyses.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “By focusing on hub genes (SRC, AKT1, MAPK1/3, STAT3, EGFR) implicated in key signaling pathways such as PI3K-Akt, MAPK, JAK-STAT, and GABAergic synapse signaling, network analysis showed that these drugs had 15-25 targets in common with epilepsy.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “We also examine the existing standards of care for NSCLC harboring EGFR and ALK alterations, as well as emerging therapies poised for clinical use.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Analysis revealed mutations in IDH1, ATRX, and EGFR, as well as a novel BCOR internal tandem duplication (ITD).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Gene expression studies showed significant down regulation of PD-L1, EGFR, STAT3, BCL2 and Ki-67, while the up regulation of Caspase-3, Caspase-9 and BAX (p < 0.0001).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Network pharmacology and protein-ligand interaction studies identified EGFR, ACHE, and PRKCG as critical molecular targets.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “RESULTS: Six preclinical and five clinical studies investigated five immune-related targets: programmed death-ligand 1 (PD-L1), epidermal growth factor receptor (EGFR), tenascin-C, the extra domain B (ED-B) of fibronectin, and cluster of differentiation 44 variant 6 (CD44v6).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “RESULTS: We categorised recurrently dysregulated genes by their biological function, including transcription factors (SOX2, ZEB2), growth factor receptors (EGFR, PDGFRA), immune-related markers (PD-L1, TAP1, B2M), extracellular matrix regulators (MMP2, LAMC1, HAS2), and metabolic genes (SLC7A11, PRMT5, NRF2).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Current progress of 1,2,3-triazole hybrids as EGFR inhibitors for cancer therapy - a literature review.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Methods: Synthesized 16 derivatives; tested for cytotoxicity, EGFR inhibition, cell cycle, apoptosis, migration; assessed antibacterial activity; performed ADMET profiling, molecular docking, molecular dynamics, and DFT calculations.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “RESULTS: Somatic variants were identified in 23 tumors, with recurrent mutations in BRCA2 (61%), TCF7L2 (52%), EGFR (43%), and SOS1 (43%).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Enriched pathways included the positive regulation of the MAPK cascade, EGFR signaling, angiogenesis, and several other pathways central to skin cancer pathogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Integrated Computational and Experimental Discovery of a Promising Xanthine Derivative with Anticancer Potential Targeting EGFR.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Osimertinib is the standard treatment for epidermal growth factor receptor (EGFR) mutations in advanced non-small cell lung cancer (NSCLC).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “These results establish how cholesterol compacts, dehydrates, and stabilizes the CD147 dimer and nominate testable hotspots for mutational validation, with implications for raft partitioning, MMP/EGFR signaling, and viral entry pathways.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Epidermal growth factor receptor (EGFR) overexpression is a key oncogenic driver in breast cancer, making it an important therapeutic target.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “This study aims to investigate the prevalence of ALK, EGFR, KRAS, ROS1, MET, BRAF, and HER2 mutations in patients with NSCLC within the Middle East and North Africa (MENA) region and to assess the current state of molecular testing and targeted treatments in the Gulf Cooperation Council (GCC) region.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Representative case studies-such as AI-optimized BTK and EGFR inhibitors-highlight real-world impact.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “We performed next-generation sequencing and found mutations in the TP53, NRAS, EGFR PDGFR, MET, KIT, ERBB2, and GUSP genes.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Protein-protein interaction (PPI) network analysis highlighted key genes like EGFR, PTGS2, and TLR4 as central nodes in diabetes-related pathways.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Design, synthesis, and cytotoxic evaluation of quinazoline-based derivatives as VEGER-2 inhibitors: comparative study against EGFR kinase activity, induction of apoptosis, and molecular docking study.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Docking simulations revealed that compounds 5d, 5e, 11a, and 11b exhibited favorable binding energies and effectively interacted with the active sites of the EGFR, CDK2, ERα, and VEGFR receptors.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Exploring the mutational spectrum of key kinase genes PIK3CA, BRAF, EGFR, ALK and ROS1 in oral squamous cell carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Four constituents of A. alba-Avicenol B, Avicenol C, Avicequinone B, and Avicequinone C-were verified, leading to the identification of 10 hub genes (i.e., EGFR, PIK3CA, JAK2, MTOR, JUN, ERBB2, IGF2, SRC, MDM2, and PARP1) associated with CRC.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “In breast cancer cell lines, SFN functions as an HDAC inhibitor and reduces the expression of ER, EGFR, & HER-2 proteins.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “In silico docking studies, the favorable binding of orientin was identified with the key oncogenic targets (EGFR, ALK, KRAS, NTRK).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “In silico ADME analysis of prospective EGFR inhibitors 7a and 9 utilizing the egg-boiled technique showed favorable lipophilicity, GIT absorption, and BBB permeability.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “All tested compounds exhibited binding affinity towards caspase-3 and the receptors EGFR, HER2 and VEGFR.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “This case report discusses an unusual presentation of epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) initially mimicking tuberculosis (TB), complicated by pituitary involvement.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “It has prominent levels of mutated genes such as TP53, KRAS, MET, and EGFR.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Several bioactive compounds from the aqueous fraction exhibited anti-breast cancer activity via EGFR tyrosine kinase inhibition.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The selected variants in six genes [DPYD (rs1801268), CACNA1S (rs772226819), EGFR (rs121434568), RYR1 (rs193922816), CYP2B6 (rs3826711), and MT-RNR1 (rs267606617, rs267606618, rs267606619)] were found to be non-existing among Saudis.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Examining proteins such as EGFR, HER2/Neu, and ER reveals their roles in cancer pathways, with pathways like PI3K/Akt/mTOR (phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin) and MAPK (mitogen-activated protein kinase) being crucial targets for therapies, potentially revolutionizing breast cancer treatment.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Development of new anticancer thiadiazole-sulfonamides as dual EGFR/carbonic anhydrase inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Design and synthesis of novel 2-S-alkylated Quinazolinones as dual BRAFV600E and EGFR inhibitors in melanoma: Mechanistic insights from apoptosis and cell cycle modulation.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “RNA sequencing technology based on TEP demonstrates excellent diagnostic power by correctly identifying LC patients alongside their oncogenic alterations of EGFR, KRAS, and ALK.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Chemoinformatics analysis of Mangifera indica leaves extracted phytochemicals as potential EGFR kinase modulators.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “New alkanesulfonate-based quinazolinone-acetohydrazide scaffolds: Rational design, synthesis, molecular docking, anticancer properties and potential EGFR and its T790M/L858R mutants inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “This study focuses on a predictive drug discovery strategy for compounds that may modulate interaction with HER-2 and EGFR, two important receptors in cancer treatment.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Introduction: In Saudi Arabia, patients with metastatic colorectal cancer (mCRC) with wild-type RAS mutations may be treated with either cetuximab plus chemotherapy (CET + CT) or panitumumab plus chemotherapy (PAN + CT), which are epidermal growth factor receptor (EGFR) antibodies.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “An innovative approach to development of new pyrazolylquinolin-2-one hybrids as dual EGFR and BRAFV600E inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Molecular docking studies showed the high affinity binding of IMT to critical proteins, including BCL2 (-6.637 kcal/mol), Caspase-6, and EGFR, which proved its potential therapeutic value.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Whereas, androgen receptor (AR), epidermal growth factor receptor (EGFR), and estrogen-sensitive receptor alpha (ESR1) were the most enriched target genes.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Our new derivatives selectively inhibited both VEGFR-2 and EGFR as they have the essential structural requirements for inhibitors of both receptors.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Tinagl1 restores tamoxifen sensitivity and blocks fibronectin-induced EMT by simultaneously blocking the EGFR and β1-integrin/FAK signaling pathways in tamoxifen-resistant breast cancer cells.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Cordycepin and Its Structural Derivatives Effectively Suppress the High Expression of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase in Breast Carcinomas: A Computational Drug Development Approach.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Epidermal growth factor receptors unveiled: a comprehensive survey on mutations, clinical insights of global inhibitors, and emergence of heterocyclic derivatives as EGFR inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “New thiazolidin-4-ones as anti-cervical cancer agents targeting EGFR: design, synthesis, and computational studies.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Comprehensive analysis and outcomes of hybridization of physiologically active heterocycles targeting epidermal growth factor receptor (EGFR).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “RESULTS: In the pan-cancer group, TP53 (58.5%), EGFR (20.4%), and KRAS (18.9%) were the most frequently mutated genes.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Immunotherapy plus Chemotherapy for Patients with EGFR-Mutated Non-Squamous Cell Lung Cancer for Disease Progression after EGFR Tyrosine-Kinase Inhibitor: A Meta-Analysis of Randomized Controlled Trials.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Bio-molecular Fe(III) and Zn(II) complexes stimulate the interplay between PI3K/AKT1/EGFR inhibition and induce autophagy and apoptosis in epidermal skin cell cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “This study examines primary molecular markers commonly assessed in GBM patients, including brain-derived neurotrophic factor (BDNF), platelet-derived growth factor receptor A (PDGFRA), O6-methylguanine DNA methyltransferase (MGMT), epidermal growth factor receptor (EGFR), and vascular endothelial growth factor A (VEGFA) using computational approaches.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Molecular mechanisms involve hormonal signaling, HER2/epidermal growth factor receptor (EGFR) pathways, tumor suppressor gene alterations, and epigenetic changes.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Dysregulation of this pathway, often due to mutations in genes such as PIK3CA, PTPN11, EGFR, and AKT1, contributes to tumorigenesis and therapy resistance.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Illuminating the role of VEGFA and EGFR in head and neck squamous cell carcinoma through the multi-omics data integration.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “While somatic mutations such as KRAS and EGFR were commonly reported in tumor studies, our primary focus is on germline PSVs that may indicate population-specific genetic risks, including BRCA1 exon 11 mutations in breast cancer and p.Gly12Asp in KRAS for colorectal cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “From EGFR mutations to STAT30-driven resistance in NSCLC: Biomarkers and multi-modal treatment approach.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The molecular landscape of TNBC is covered in the first section, which keeps the focus on transcriptome and genomic profiling while highlighting key molecular targets like mutations in the BRCA1/2, PIK3CA, androgen receptors (AR), epidermal growth factor receptors (EGFR), and immunological checkpoint molecules.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Comprehensive evaluation of EGFR and AKT targeting efficacy of resveratrol loaded PEGylated liposomes for the glioblastoma management: In silico, in vitro BBB permeation studies.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Finally, we performed theoretical studies of molecular docking, molecular dynamics and interactions between lamivudine and key proteins regulating necroptosis, including epidermal growth factor receptor (EGFR), receptor-interacting protein kinase 1 (RIPK1), and receptor-interacting protein kinase 3 (RIPK3).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Network pharmacology identified 24 hub targets, and molecular docking revealed strong binding affinities (-6.5 to -9.1 kcal/mol) between BRLE compounds and inflammatory proteins including EGFR, SRC, STAT3, and AKT1.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Effect of Nano-Gefitinib on Solid Ehrlich Carcinoma via Targeting EGFR, RIPK2 Pathways, and Macrophage Reprogramming.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “RESULTS: The review identified several IHC markers, including p53, Ki-67, EGFR, and p16, as frequently associated with early dysplastic changes and malignant transformation in the oral mucosa.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “RESULTS: Combining the results of network pharmacology with other bioinformatics databases suggests that myrrh's active components exert anti-cancer effects by regulating genes involved in breast cancer pathogenesis, particularly PTGS2, EGFR, ESR2, MMP2, and JUN.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Key targets like MMP9, EGFR, and AKT1 were highlighted, and the PPAR and PI3K-AKT signaling pathways were identified as the primary mechanisms through which CT may treat DN.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Six rats in each group were euthanized at each time point for histopathological, immunohistochemical examination of collagen, the levels of alpha-smooth muscle actin (α-SMA), and epidermal growth factor receptor (EGFR). additionally, the gene expression analysis of the relative renal nuclear factor erythroid 2-related factor2 (Nrf2 mRNA), Transforming growth factor beta-1 (TGFβ1), fibroblast growth factor-7 (FGF7), Transforming growth factor beta-1 (TGFβ1), Lysyl oxidase (LOX), and Vascular endothelial growth factor (VEGF) were applied.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Case Series: EGFR and ROS-1 Co-Occurrence in Advanced Non-Small Cell Lung Cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “One gene EGFR was found to have functional association with ID anemia, suggesting potential for using E. sativa extracts.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Epidermal Growth Factor Receptor (EGFR) was mutated in 5/17 (29%) patients.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Elucidating gastric cancer mechanisms and therapeutic potential of Adociaquinone A targeting EGFR: A genomic analysis and Computer Aided Drug Design (CADD) approach.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Specifically, E5, E6, and E7 proteins disrupt the signaling pathways like p53, retinoblastoma tumor suppressor protein (pRB), The phosphoinositide 3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR), epidermal growth factor receptor (EGFR), mitogen-activated protein kinases (MAPK)/extracellular signal-regulated kinases (ERK), and Wnt/β-catenin, promoting HPV-mediated carcinogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “A significant upregulation of CART, VACHT, EGFR, caspase-3, NOS-1, and miR-27a-5p was evident in the stomach of the AMD group.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Pathway enrichment was performed with Gene Ontology and KEGG databases; (3) Results: We identified 28 active phytoconstituents, targeting proteins such as EGFR, SRC, STAT3, AKT1, and HSP90AA1.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Small molecule inhibitors targeting genetic mutations like EGFR and ALK have shown promise in NSCLC treatment.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The advanced non-small cell lung cancer (NSCLC) that harbors epidermal growth factor receptor (EGFR) mutations has put a selective pressure on the discovery and development of newer EGFR inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Furthermore, network pharmacology analysis identified the top 10 hub genes, namely AKT1 (protein kinase B), CTNNB1 (catenin beta-1), SRC (proto-oncogene c-Src), TNF (tumor necrosis factor), EGFR (epidermal growth factor receptor), HSP90AA1 (heat shock protein 90α), MAPK3 (mitogen-activated protein kinase 3), STAT3 (signal transducer and activator of transcription 3), CASP3 (caspase protein), and ESR1 (estrogen receptor 1), which are responsible for hepatoprotective activity.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “BBR's ability to modulate chemoresistance is attributed to its diverse mechanisms of action, including inducing DNA breaks, inhibition of drug efflux pumps, modulation of apoptosis and necroptosis, downregulating multidrug resistance genes, enhancing immune response, suppressing angiogenesis and targeting multiple pathways within cancer cells, including protein kinase B/mammalian target of rapamycin (Akt/mTOR), epidermal growth factor receptor (EGFR), mitogen-activated protein kinase (MAPK), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), poly(ADP-ribose) polymerase (PARP1), janus kinase/signal transducers and activators of transcription (JAK-STAT), Wnt/β-catenin etc.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Five proteins (i.e., EGFR, MAPK3, ESR1, MAPK1, and PTGS2) associated with breast cancer were selected as receptor proteins.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The top KEGG signaling pathways according to fold enrichment analysis was the EGFR tyrosine kinase inhibitor resistance pathway.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Bioinformatics-driven discovery of novel EGFR kinase inhibitors as anti-cancer therapeutics: In silico screening and in vitro evaluation.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “New Theobromine Apoptotic Analogue with Anticancer Potential Targeting the EGFR Protein: Computational and In Vitro Studies.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “METHODS: Approximately 950 compounds were virtually screened against the two most promising targets of glioblastoma, i.e., epidermal growth factor receptor (EGFR) and phosphoinositide 3-kinase (PI3K).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer cells.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Nine variants were missense, which included an insertion in EGFR c.1819_1820insCA, causing frameshifting, and a single nucleotide deletion in HRAS and HNF1A genes, causing frameshifting in these genes.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “We predicted that miR-200c-3p plays a markable role in the development of AA by its effect on the EGFR tyrosine kinase inhibitor resistance pathway.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The etiology of GBM may involve various cellular and molecular pathways, including EGFR, PDCD4, NF-κB, MAPK, matrix metalloproteinases, STAT, and Akt.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The in-depth analysis based on the degree revealed that AKT1 and EGFR formed the foundation of the PPI network.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Super enhancer loci of EGFR regulate EGFR variant 8 through enhancer RNA and strongly associate with survival in HNSCCs.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “RESULTS: The findings revealed that Cucurbita pepo contains 18 active components and has 192 potential gene targets, including AR, EGFR, ESR1, AKT1, MAPK3, SRC, and MTOR.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Also, their ability to bind with both EGFR and VEGFR-2 receptors was examined by molecular modeling.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The emerging role of noncoding RNAs in the EGFR signaling pathway in lung cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Exploring EGFR inhibitors with the aid of virtual screening, docking, and dynamics simulation studies.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Identification of potential edible spices as EGFR and EGFR mutant T790M/L858R inhibitors by structure-based virtual screening and molecular dynamics.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “A new theobromine-derived EGFR inhibitor (2-(3,7-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)-N-(2,6-dimethylphenyl)acetamide) has been developed that has the essential structural characteristics to interact with EGFR's pocket.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Computer aided drug discovery (CADD) of a thieno[2,3-d]pyrimidine derivative as a new EGFR inhibitor targeting the ribose pocket.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “BACKGROUND: Epidermal growth factor receptor (EGFR/HER-1) and its role in tumor development and progression through the mechanism of tumor angiogenesis is prevalent in non-small lung cancer, head and neck cancer, cholangiocarcinoma & glioblastoma.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Integrin Subunit Alpha 1 (ITGA1) is one among the integrin family and helps in regulating the Epidermal Growth Factor receptor (EGFR) pathway, consequently affects proliferation and healing.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Targeting EGFR/PI3K/AKT/mTOR signaling in lung and colon cancers: synthesis, antitumor evaluation of new 1,2,4-oxdiazoles tethered 1,2,3-triazoles.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Epidermal growth factor receptor (EGFR) mutations were positive in two (4.5%) cases and ALK mutation was positive in two (4.5%) cases.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The over-expression of several proteins, including Heat shock proteins, Cofilin, Annexins, Insulin-like growth factor, transforming growth factor-β, Receptor tyrosine kinase, Ezrin, Runx2, SATB2, ATF4, Annexins, cofilin, EGFR, VEGF, retinoblastoma 1 (Rb1) and secreted protein, has been associated to the development and progression of osteosarcoma.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The frontier anticancer candidates against the MDA-MB-468 were also examined against the wild EGFR (EGFR-WT) and mutant EGFR (EGFR-T790M) receptors.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “In this study, we are addressing this need by investigating the effect of several BUVs on the activity of the human epidermal growth factor receptor (EGFR), an important regulator of cellular processes that has recently been identified as a cell-surface receptor for environmental organic chemicals.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “High throughput virtual screening and validation of Plant-Based EGFR L858R kinase inhibitors against Non-Small cell lung Cancer: An integrated approach Utilizing GC-MS, network Pharmacology, Docking, and molecular dynamics.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “From enrichment analysis, we found NF-ΚB1, AKT1, EGFR, JUN, and RELA as the main regulators in the DCKD development through mitogen activated protein kinase (MAPK) pathway signalling.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The present study aimed to evaluate the expression of vascular endothelial growth factor (VEGF), Bcl-2-associated X protein (BAX), epidermal growth factor receptors (EGFR), ProExTMC, and human telomerase reverse transcriptase (hTERT) and assess their association with survival and clinicopathological characteristics.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Using multi-omics profiling, we identified the dysregulation of endothelial growth factor (EGFR) and tumor necrosis factor (TNF) signaling pathways in PGM3 and STAT3 patients, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Design, synthesis, docking, ADMET and anticancer evaluations of N-alkyl substituted iodoquinazoline derivatives as dual VEGFR-2 and EGFR inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Computer-Assisted Drug Discovery of a Novel Theobromine Derivative as an EGFR Protein-Targeted Apoptosis Inducer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Background and objectives: Non-small cell lung cancer (NSCLC) is often caused by EGFR mutations, leading to overactive cell growth pathways.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “RESULTS: Out of total identified 269 DEGs, EGFR (epidermal growth factor receptor), HMOX1 (heme oxygenase-1), PGR (progesterone receptor), CXCL10 (C-X-C motif chemokine ligand 10), CCL5 (C-C motif chemokine ligand 5), and IL12B (interleukin 12B) were prioritized as top DEGs in OP patients.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The data obtained revealed that most of these compounds were potent, with variable degrees of target selectivity and dual EGFR/VGFR2 inhibitors at the IC50 value range, i.e., 0.3-24 µM.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “According to the PPI network and core targets study, the main targets against PSO were EGFR, SRC, STAT3, ERBB2, PTK2, SYK, EP300, CBL, TP53, and AR.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “This study aims to determine whether combining erlotinib, an epidermal growth factor receptor (EGFR) inhibitor, with cabozantinib, a mesenchymal-epithelial transition factor (c-Met) inhibitor, would have an augmented therapeutic benefit on A549 cells.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The most effective antiproliferative derivatives, 3f-j, were subsequently investigated as possible multi-target inhibitors of EGFR, BRAFV600E, and EGFRT790M.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Discovery of new thieno[2,3-d]pyrimidines as EGFR tyrosine kinase inhibitors for cancer treatment.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Additionally, the potential of compound 5d as a multi-targeted kinase inhibitor was examined against different protein kinases, including VEGFR2, EGFR, HER2, and CDK2.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Surprisingly, 3h showed a remarkable potency against mutated EGFR and B-RAF, being 4 and 1.3 more selective to the mutated enzymes over the wild-type forms (EGFRT790M IC50 = 69 nM and B-RAFV600E IC50 = 83 nM).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “It has been shown to regulate multiple crucial cellular signaling pathways, including those mediated by EGFR, JAK-STAT, MAPKs, NF-κB, PI3K-AKT-mTOR, and others.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “A new series of indole-2-carboxamides 5a-g, 6a-f and pyrido[3,4-b]indol-1-ones 7a and 7b have been developed as new antiproliferative agents that target both wild and mutant type EGFR.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Compound 8c was investigated for epidermal growth factor receptor (EGFR) inhibition; it exhibited promising IC50 values of 96.6 nM compared with 67.3 nM for erlotinib.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “In summary, we proposed that quercetin, luteolin, apigenin, catechin, epicatechin, stigmasterol, beta-sitosterol, celastrol, and betulic acid inhibit tumor growth by affecting tumor protein 53 (TP53), interleukin 6 (IL6), RAC-alpha serine/threonine protein kinases 1 (AKT1), caspase-3 (CASP3), tumor necrosis factor (TNF), jun proto-oncogene (JUN), heat shot protein 90 AA1 (HSP90AA1), vascular endothelial growth factor A (VEGFA), epidermal growth factor receptor (EGFR), and SRC proto-oncogene (SRC).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Relationship between compounds, target genes, and pathways revealed that J. humile exerts its effect on breast cancer by altering, Estrogen signaling pathway, HER2, and EGFR overexpression.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Furthermore, compounds 8 and 14 were assessed for their EGFR kinase (Wild and T790M) inhibitory activities, revealing eligible potential.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Structure-Based Virtual Screening, Molecular Docking, Molecular Dynamics Simulation of EGFR for the Clinical Treatment of Glioblastoma.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Gastric cancers are caused primarily due to the activation and amplification of the EGFR or HER2 kinases resulting in cell proliferation, adhesion, angiogenesis, and metastasis.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Notch signaling, PTEN/Akt/mTOR axis, KRAS mutation, JAK/STAT signaling, P53, EGFR, and the VEGFs have all been linked to OC, and miRNAs have been shown to have a role in all of these.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Aim: Our objective was to design and synthesize a new range of pyrazolopyrimidines while maintaining the key pharmacophoric features of EGFR tyrosine kinase inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Identification of Potent Inhibitors Targeting EGFR and HER3 for Effective Treatment of Chemoresistance in Non-Small Cell Lung Cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “PTPN23 is a regulator of endosomal trafficking functioning to move activated membrane receptors, such as EGFR, from the endosomal sorting complex towards the ESCRT-III complex for multivesicular body biogenesis, lysosomal degradation, and subsequent downregulation of receptor signaling.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The US Food and Drugs Administration (FDA) has recently approved dacomitinib as a first-line treatment for patients suffering from non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Mutant EGFR/BRAF pathways are thought to be crucial targets for the development of anticancer drugs since they are over-activated in several malignancies.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Molecular abnormalities related to epidermal growth factor receptor (EGFR), v-Raf murine sarcoma viral oncogene homolog B1 (B-RAF) Kirsten rat sarcoma virus (KRAS) mutations, translocation of the anaplastic lymphoma kinase (ALK) gene, mesenchymal-epithelial transition factor (MET) amplification have been studied to overcome the resistance and to develop new therapies for non-small cell lung cancer (NSCLC).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Epidermal growth factor receptor (EGFR) is a transmembrane protein tyrosine kinase that is usually overexpressed in many types of cancers.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Network pharmacology analysis revealed 171 potential UC targets for the bioactive compounds, including EGFR, LRRK2, and HSP90 as top targets, which were found to bind to key CGBRE compounds through molecular docking.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Dual luciferase reporter gene assay and RNA pull-down assay were carried out to verify the relationship between ITGB2-AS1 and miR-338-3p or miR-338-3p and epidermal growth factor receptor (EGFR).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “One of the most common strategies is single-gene testing, which is often conducted for known mutations, such as BRAF in melanoma and EGFR in lung cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Based on the pharmacophoric features of EGFR inhibitors, a new semisynthetic theobromine-derived compound was designed to interact with the catalytic pocket of EGFR.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Compounds 8, 10, 12a, and 12b were evaluated for their kinase inhibitory activities against wild EGFR (EGFRWT).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “ZFB is Epidermal Growth Factor Receptor (EGFR) inhibitor that is characterized by good permeability of the blood-brain barrier for (NSCLC) patients with EGFR mutations.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Epidermal Growth Factor Receptor (EGFR), its wild type and mutations L858R/T790M, is overexpressed in non-small cell lung cancer (NSCLC) patients and is considered an inevitable oncology target.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “A new series of pyrido[2,3-d]pyrimidin-4(3H)-one derivatives having the essential pharmacophoric features of EGFR inhibitors has been designed and synthesised.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “This study aimed at evaluating the relationship between the expression of epidermal growth factor receptor (EGFR) and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) and tumor radiosensitivity in patients with non-small cell lung cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “In Silico Screening of Synthetic and Natural Compounds to Inhibit the Binding Capacity of Heavy Metal Compounds against EGFR Protein of Lung Cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Moreover, gene alterations in APC, EGFR, FBXW7, TP53, PTEN, K-ras genes were concomitant in CRC.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “A new class of EGFR PROTACs based on pomalidomide was developed, synthesised, and tested for their cytotoxic activity against a panel of human cancer cells.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “In this work, several chalcones containing the ligustrazine moiety were synthesized and tested for their in vitro anticancer activity and several cancer markers, including EGFR, BRAFV600E, c-Met, and tubulin polymerization, in order to uncover multitarget bioactive compounds.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “HLA-A in prostate cancer, MSR1 in familial prostate cancer, and EGFR in both castration-resistant prostate cancer and metastatic castration-resistant had the highest allele frequencies of splice-disrupt variations.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “We also detected mutations in other genes, including BRAF, EGFR, and KRAS.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “A docking simulation of compound 6b was carried out to correlate its molecular structure with its significant EGFR inhibition potency and its possible binding interactions within the active site of EGFRWT and the mutant EGFRT790M.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Single gene testing for epidermal growth factor receptor (EGFR) for patients who underwent tissue biopsy showed a 35% mutation rate.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “This review and research study leads to the conclusion that growth promoting pathways (EGFR, Ras, and PI3K), growth inhibitory pathways (p53 and STK11), apoptotic pathways (Bcl- 2/Bax/Fas), and DDR pathways and genes are commonly and dominantly altered in both the cases COVID-19 and lung cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “In some cases, gene mutations including P16, TP53, and EGFR, have been observed in GBM.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The key genes, including EGFR, MYC, VEGFA, and PTEN, are targeted by TF such as AR, Sp1, TP53, NF-KB1, STAT3, RELA.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The computational pathway analysis illustrated that JGF might inhibit renal failure through PI3K-Akt, MAPK signaling pathway, and EGFR tyrosine kinase inhibitor resistance.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Multiple robust and well-tolerated TKIs targeting single or multiple targets, including EGFR, ALK, ROS1, HER2, NTRK, VEGFR, RET, MET, MEK, FGFR, PDGFR, and KIT, have been developed over the last two decades, contributing to our understanding of precision cancer medicine based on a patient's genetic alteration profile.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The known synonymous mutations were found in this tumor were, in exon 14 of FGFR3 in c.1953G>A; in exon 12 of PDGFRA in c.1701A>G; in exon 18 of PDGFRA c.2472C>T; in exon 20 of EGFR in c.2361G>A; in exon 13 of RET in c.2307G>T; in exon 16 of APC in c.4479G>A; and in exon 2 of MET in c.534C>T.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Objectives To estimate the proportion of positive epidermal growth factor receptor (EGFR) mutations among patients diagnosed with non-small cell lung carcinoma (NSCLC) and T790M at the King Khalid University Hospital (KKUH).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Discovery, Development, Inventions, and Patent Trends on Mobocertinib Succinate: The First-in-Class Oral Treatment for NSCLC with EGFR Exon 20 Insertions.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Globally Approved EGFR Inhibitors: Insights into Their Syntheses, Target Kinases, Biological Activities, Receptor Interactions, and Metabolism.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “BACKGROUND: Rociletinib (CO-1686; RLC) is a new, small molecule that is orally administered to inhibit mutant-selective covalent inhibitor of most epidermal growth factor receptor (EGFR)-mutated forms, including T790M, L858R, and exon 19 deletions, but not exon 20 insertions.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “In the present study, we showed that in addition to weakening the inhibitory interaction between p85α and p110α, a group of driver mutations in the p85α N-terminal SH2 domain activated EGFR, HER2, HER3, c-Met, and IGF-1R in a p110α-independent manner.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “APC, RET, and EGFR genes were most frequently mutated.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “New pyrimidine and pyrazole-based compounds as potential EGFR inhibitors: Synthesis, anticancer, antimicrobial evaluation and computational studies.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “We identified recurrent amplifications in the 1q31, 7q35, 14q11, 22q11, and 22q13 regions and observed amplification of EGFR in 25% of samples with tobacco consumption history.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Profiling non-small cell lung cancer reveals that PD-L1 is associated with wild type EGFR and vascular invasion, and immunohistochemistry quantification of PD-L1 correlates weakly with RT-qPCR.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The combination also inhibited EGFR, increased the preG1/S cell cycle phases, apoptosis, and caspase 8 in HT29 cells, while it increased the G1 phase, p21/p27, and apoptosis in HT29-5FU cells.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Development of pyridazine derivatives as potential EGFR inhibitors and apoptosis inducers: Design, synthesis, anticancer evaluation, and molecular modeling studies.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “AIM: To compare the efficacy and safety of tyrosine kinase inhibitors (TKIs) as first-line treatment in patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC) with positive EGFR mutation.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Uncommon EGFR mutations in lung adenocarcinoma: features and response to tyrosine kinase inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “833 samples of non-small cell lung cancer from 799 patients who received resection of their lung cancer, were selected for molecular analysis of six known mutations, including EGFR, KRAS, BRAF, PIK3CA, HER2 and ALK.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Novel quinazoline-based EGFR kinase inhibitors: A review focussing on SAR and molecular docking studies (2015-2019).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Moreover, compound 11j is also showed moderate EGFR inhibition with IC50 of 5.827 ± 0.46 µM, but significantly inhibited the Wnt/β-catenin pathway with IC501286.96 ± 12.37 ng/mL.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Seven synonymous mutations were detected in this tumor, viz., in IDH1 (rs11554137), in FGFR3 (rs7688609), in PDGFRA (rs1873778), in APC (COSM3760869), in EGFR (rs1050171), in MET (rs35775721), and in RET (rs1800861), respectively.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “RESULTS: Sequencing analysis identified missense, nonsense and frameshift mutations in TP53 (66%), PIK3CA (27%), CDKN2A (25%), EGFR (18%), and PTEN (14%).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “PURPOSE: To identify computed tomography (CT) features of epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma in Canadian population and whether imaging-based surrogate markers of EGFR mutation in our population were similar to those found in the Asian population.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “RESULTS: Synergy was observed between dacomitinib and fulvestrant in three human ERβ+ NSCLC models: 201T (wild-type EGFR), A549 (KRAS mutant), and HCC827 (EGFR 19 deletion) with combination indices of 0.1-0.6.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Screening of RAS (Kirsten rat sarcoma viral oncogene homolog (KRAS), neuro-blastoma RAS viral oncogene homolog (NRAS), and v-raf murine sarcoma viral oncogene homolog B1 (BRAF)) somatic mutations is necessary prior to considering anti-epidermal growth factor receptor (EGFR) therapies in CRC patients.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “3'-(4-(Benzyloxy)phenyl)-1'-phenyl-5-(heteroaryl/aryl)-3,4-dihydro-1'H,2H-[3,4'-bipyrazole]-2-carboxamides as EGFR kinase inhibitors: Synthesis, anticancer evaluation, and molecular docking studies.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Eight synonymous mutations were found in FGFR3, PDGFRA, EGFR, RET, HRAS, FLT3, APC and SMAD4 genes.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Nazartinib (EGF816, NZB) is a promising third-generation human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “We investigated the cytotoxicity of lapatinib by MTT assay, mode of cell death using apoptosis-necrosis assay, DNA damage using micronucleus test, EGFR protein expression by immunocytochemistry, and assessed its effect on EGFR (7p11.2 locus) and TP53 (17p13 locus) genes using interphase-FISH technique.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “However, treatment with both first- and second-generation TKIs results in acquired resistance and is related to various toxicities; the EGFR T790M mutation has been associated with this resistance.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Molecular designing, virtual screening and docking study of novel curcumin analogue as mutation (S769L and K846R) selective inhibitor for EGFR.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Interestingly, all of EGFR, JAK2, NR3C1, PDZD2, and SEMA3C genes had single nucleotide polymorphisms (SNP) in castration-resistant prostate cancer, consistent with high selection pressure on these genes during drug treatment and consequent resistance.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Olmutinib (OTB, Olita™) is an orally available third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “EGF ligand fused to truncated Pseudomonas aeruginosa exotoxin A specifically targets and inhibits EGFR‑positive cancer cells.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “In this study, we studied epidermal growth factor receptor (EGFR), tumor protein p53 (TP53), Kirsten rat sarcoma 2 viral oncogene homolog (KRAS), and Serine/Threonine Kinase 11 (STK11) to construct the ERSDM profile.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “OBJECTIVE: Evaluate the frequency and prognostic effect of RAS, BRAF, PIK3CA, PTEN, and EGFR somatic mutations as well as mismatch repair (MMR) deficiency in Lebanese Middle Eastern patients.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The epidermal growth factor receptor (EGFR) is a cell surface receptor belonging to erythroblastic leukemia viral oncogene homologue (ErbB) family of tyrosine kinase.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Erlotinib is a first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) approved in the first-line treatment of advanced non-small-cell lung cancer (NSCLC) patients with sensitizing epidermal growth factor receptor (EGFR) mutations.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “MATERIALS & METHODS: Eligible NSCLC patients had progressed after clinical benefit on prior erlotinib/gefitinib and/or had activating EGFR/HER2 mutations, exhausted all other treatments, and were ineligible for afatinib trials.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Novel quinoline-3-carboxamides (Part 2): Design, optimization and synthesis of quinoline based scaffold as EGFR inhibitors with potent anticancer activity.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Therapies targeting epidermal growth factor receptor (EGFR) have variable and unpredictable responses in breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The therapeutic options of nonsmall cell lung cancer (NSCLC) therapy has been changed since the first discovery of activating epidermal growth factor receptor (EGFR) mutations and the development of specific EGFR tyrosine kinase inhibitors, which resulted in the evolution of "personalized medicine." There are a considerable number of genomic aberrations in NSCLC serving as potential predictive biomarkers and drug targets and still more.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Tyrosine kinase domain mutations of EGFR gene in head and neck squamous cell carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Ba-Hammam, Mohammad Athar P112 Epithelial ovarian carcinoma (EOC): Systems oncological approach to identify diagnostic, prognostic and therapeutic biomarkers Gauthaman Kalamegam, Peter Natesan Pushparaj, Muhammad Abu-Elmagd, Farid Ahmed Khalid HussainWali Sait, Nisreen Anfinan, Mamdooh Gari, Adeel Chaudhary, Adel Abuzenadah, Mourad Assidi, Mohammed Al-Qahtani P113 Crohn’s disease phenotype in northern Tunisian population Naira Ben Mami, Yosr Z Haffani, Mouna Medhioub, Lamine Hamzaoui, Ameur Cherif, Msadok Azouz P114 Establishment of In Silico approaches to decipher the potential toxicity and mechanism of action of drug candidates and environmental agents Gauthaman Kalamegam, Fazal Khan, Shilu Mathew, Mohammed Imran Nasser, Mahmood Rasool, Farid Ahmed, Peter Natesan Pushparaj, Mohammed Al-Qahtani P115 1q Gain predicts poor prognosis marker for young breast cancer patients Shereen A Turkistany, Lina M Al-harbi, Ashraf Dallol, Jamal Sabir, Adeel Chaudhary, Adel Abuzenadah P116 Disorders of sex chromosomes in a diagnostic genomic medicine unit in Saudi Arabia: Prevalence, diagnosis and future guidelines Basmah Al-Madoudi, Bayan Al-Aslani, Khulud Al-Harbi, Rwan Al-Jahdali, Hanadi Qudaih, Emad Al Hamzy, Mourad Assidi, Mohammed Al Qahtani P117 Combination of WYE354 and Sunitinib demonstrate synergistic inhibition of acute myeloid leukemia in vitro Asad M Ilyas, Youssri Ahmed, Mamdooh Gari, Farid Ahmed, Mohammed Alqahtani P118 Integrated use of evolutionary information in GWAS reveals important SNPs in Asthma Nada Salem, Sajjad Karim, Elham M Alhathli, Heba Abusamra, Hend F Nour Eldin, Mohammed H Al-Qahtani, Sudhir Kumar P119 Assessment of BRAF, IDH1, IDH2, and EGFR mutations in a series of primary brain tumors Fatima Al-Adwani, Deema Hussein, Mona Al-Sharif, Awatif Jamal, Fahad Al-Ghamdi, Jaudah Al-Maghrabi, Saleh S Baeesa, Mohammed Bangash, Adeel Chaudhary, Mohammed Al-Qahtani, Hans-Juergen Schulten P120 Expression profiles distinguish oligodendrogliomas from glioblastoma multiformes with or without oligodendroglioma component Alaa Alamandi, Reem Alotibi, Deema Hussein, Sajjad Karim, Jaudah Al-Maghrabi, Fahad Al-Ghamdi, Awatif Jamal, Saleh S Baeesa, Mohammed Bangash, Adeel Chaudhary, Hans-Juergen Schulten, Mohammed Al-Qahtani P121 Hierarchical clustering in thyroid goiters and hyperplastic lesions Ohoud Subhi, Nadia Bagatian, Sajjad Karim, Adel Al-Johari, Osman Abdel Al-Hamour, Hosam Al-Aradati, Abdulmonem Al-Mutawa, Faisal Al-Mashat, Jaudah Al-Maghrabi, Hans-Juergen Schulten, Mohammad Al-Qahtani P122 Differential expression analysis in thyroiditis and papillary thyroid carcinomas with or without coexisting thyroiditis Nadia Bagatian, Ohoud Subhi, Sajjad Karim, Adel Al-Johari, Osman Abdel Al-Hamour, Abdulmonem Al-Mutawa, Hosam Al-Aradati, Faisal Al-Mashat, Mohammad Al-Qahtani, Hans-Juergen Schulten, Jaudah Al-Maghrabi P123 Metagenomic analysis of waste water microbiome in Sausdi Arabia Muhammad W shah, Muhammad Yasir, Esam I Azhar, Saad Al-Masoodi P124 Molecular characterization of Helicobacter pylori from faecal samples of Tunisian patients with gastric cancer Yosr Z Haffani, Msadok Azouz, Emna Khamla, Chaima Jlassi, Ahmed S.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “ROS1 testing is often only considered after negative tests for EGFR mutation and ALK gene rearrangement, based on the assumption that these oncogenic driver events tend to be exclusive.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “CONTEXT: -The National Cancer Care Network and the combined College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology guidelines indicate that all lung adenocarcinomas (ADCs) should be tested for epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “RESULTS: Targeted sequencing lead to the identification of frequent mutations in TP53 (65 %), APC (36 %), KRAS (35 %), PIK3CA (19 %), PTEN (13 %), EGFR (11 %), SMAD4 (11 %), and FBXW7 (7 %).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Immuno- and gene expression analysis of EGFR and Nestin during mice skin development.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Because mutations within HER1/EGFR are predictive of response to tyrosine kinase inhibitors (TKI) in lung cancer, we investigated whether mutations in HER family kinase domains are predictive of response to targeted therapy in HER2-overexpressing breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Data collected included demographic information, disease characteristics and EGFR test results.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “METHODS: K-RAS (exons 2, 3, 4) wild type colorectal cancer patients, candidates to second/third-line cetuximab with chemotherapy were prospectively allocated into 2 groups on the basis of their profile: favourable (BRAF and PIK3CA exon 20 wild type, EGFR GCN ≥ 2.6, HER-3 Rajkumar score ≤ 8, IGF-1 immunostaining < 2) or unfavourable (any of the previous markers altered or mutated).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Activating alterations in several potential driver oncogenic genes have been identified, including EGFR, ROS1 and ALK and understanding of their molecular mechanisms underlying development, progression, and survival of lung cancer has led to the design of personalized treatments that have produced superior clinical outcomes in tumours harbouring these mutations.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Molecular interaction of a kinase inhibitor midostaurin with anticancer drug targets, S100A8 and EGFR: transcriptional profiling and molecular docking study for kidney cancer therapeutics.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Our objective is to compare the yield of different diagnostic procedures for cellular differentiation of NSCLC and analysis of epidermal growth factor receptor (EGFR) mutation.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “BACKGROUND: Targeting epidermal growth factor receptors (EGFR) is an innovative approach to managing non-small cell lung cancer (NSCLC) which harbors EGFR mutation.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “The roles of epidermal growth factor receptor (EGFR) inhibitors in the management of lung cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “EGFR mutation testing in non-small cell lung cancer (NSCLC).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Very low prevalence of epidermal growth factor receptor (EGFR) protein expression and gene amplification in Saudi breast cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “In a fraction of patients with known EGFR mutation status, GBT showed significantly higher ORR among patients with mutant EGFR (odds ratio [OR] = 2.81, 95% CI: 1.71-4.62, P < 0.0001); however, EGFR mutation was not associated with better PFS or OS with GBT.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “ER, PR, HER2, EGFR and CK5/6 were used as surrogate markers for gene expression profiling to classify 231 breast cancer specimens.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “HER2, TOP2A, CCND1, EGFR and C-MYC oncogene amplification in colorectal cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Epidermal growth factor receptor (EGFR) exon 18-21 mutations were shown to be highly predictive of response to gefitinib (Iressa) therapy in lung cancer.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Tissue microarrays were analyzed by fluorescence in situ hybridization for HER2, CCND1, MYC, and EGFR amplification.” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Multiple different oncogenes have been described previously to be amplified in breast cancer including HER2, EGFR, MYC, CCND1, and MDM2.” | 0.98 | hgnc_dict_v1 |