lung cancer
SaudiVarKB evidence summary derived from retained literature mentions.
299Phenotype mentions
100Publications
50Associated gene records
50Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| EGFR | HGNC:3236 | 67 | 67 |
| KRAS | HGNC:6407 | 17 | 17 |
| ALK | HGNC:427 | 16 | 16 |
| ROS1 | HGNC:10261 | 10 | 10 |
| STAT3 | HGNC:11364 | 8 | 8 |
| BRAF | HGNC:1097 | 6 | 6 |
| PTEN | HGNC:9588 | 4 | 4 |
| ESR1 | HGNC:3467 | 4 | 4 |
| PIK3CA | HGNC:8975 | 4 | 4 |
| APC | HGNC:583 | 4 | 4 |
| TNF | HGNC:11892 | 3 | 3 |
| CS | HGNC:2422 | 3 | 3 |
| TP53 | HGNC:11998 | 3 | 3 |
| BAX | HGNC:959 | 3 | 3 |
| NEAT1 | HGNC:30815 | 3 | 3 |
| CDK2 | HGNC:1771 | 3 | 3 |
| XRCC1 | HGNC:12828 | 3 | 3 |
| RET | HGNC:9967 | 2 | 2 |
| NLRP3 | HGNC:16400 | 2 | 2 |
| SOD1 | HGNC:11179 | 2 | 2 |
| PPARG | HGNC:9236 | 2 | 2 |
| IL6 | HGNC:6018 | 2 | 2 |
| BCL2 | HGNC:990 | 2 | 2 |
| PTGS2 | HGNC:9605 | 2 | 2 |
| BRCA1 | HGNC:1100 | 2 | 2 |
| CD44 | HGNC:1681 | 2 | 2 |
| SMAD4 | HGNC:6770 | 2 | 2 |
| HSP90AA1 | HGNC:5253 | 2 | 2 |
| CCL2 | HGNC:10618 | 2 | 2 |
| CDH1 | HGNC:1748 | 2 | 2 |
| CDKN2A | HGNC:1787 | 2 | 2 |
| EZH2 | HGNC:3527 | 2 | 2 |
| CASP3 | HGNC:1504 | 2 | 2 |
| HIF1A | HGNC:4910 | 2 | 2 |
| NRAS | HGNC:7989 | 2 | 2 |
| PRMT5 | HGNC:10894 | 2 | 2 |
| CXCR4 | HGNC:2561 | 2 | 2 |
| PVT1 | HGNC:9709 | 2 | 2 |
| HRAS | HGNC:5173 | 2 | 2 |
| ERBB2 | HGNC:3430 | 2 | 2 |
| AURKB | HGNC:11390 | 2 | 2 |
| CD4 | HGNC:1678 | 1 | 1 |
| PAH | HGNC:8582 | 1 | 1 |
| CDK4 | HGNC:1773 | 1 | 1 |
| ZEB1 | HGNC:11642 | 1 | 1 |
| CD40 | HGNC:11919 | 1 | 1 |
| TBX4 | HGNC:11603 | 1 | 1 |
| AR | HGNC:644 | 1 | 1 |
| TG | HGNC:11764 | 1 | 1 |
| CYP2D6 | HGNC:2625 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| T790M | T790M | 5 | 5 |
| T790M | T790M | 4 | 4 |
| C797S | C797S | 3 | 3 |
| L858R | L858R | 3 | 3 |
| C797S | C797S | 2 | 2 |
| rs1800629 | rs1800629 | 1 | 1 |
| R721G | R721G | 1 | 1 |
| A756D | A756D | 1 | 1 |
| Y791C | Y791C | 1 | 1 |
| E734K | E734K | 1 | 1 |
| E805K | E805K | 1 | 1 |
| F893L | F893L | 1 | 1 |
| R897Q | R897Q | 1 | 1 |
| R897G | R897G | 1 | 1 |
| R912Q | R912Q | 1 | 1 |
| R912G | R912G | 1 | 1 |
| M918T | M918T | 1 | 1 |
| p.Met918Thr | p.Met918Thr | 1 | 1 |
| p.Arg897Gln | p.Arg897Gln | 1 | 1 |
| rs4950928 | rs4950928 | 1 | 1 |
| C712R | C712R | 1 | 1 |
| rs193922722 | rs193922722 | 1 | 1 |
| Q633L | Q633L | 1 | 1 |
| rs2144684101 | rs2144684101 | 1 | 1 |
| C255G | C255G | 1 | 1 |
| rs1242097924 | rs1242097924 | 1 | 1 |
| D55G | D55G | 1 | 1 |
| rs2044414353 | rs2044414353 | 1 | 1 |
| G12C | G12C | 1 | 1 |
| rs361525 | rs361525 | 1 | 1 |
| rs3804099 | rs3804099 | 1 | 1 |
| rs3804100 | rs3804100 | 1 | 1 |
| G12D | G12D | 1 | 1 |
| rs822336 | rs822336 | 1 | 1 |
| rs2297136 | rs2297136 | 1 | 1 |
| rs4143815 | rs4143815 | 1 | 1 |
| G12C | G12C | 1 | 1 |
| C118T | C118T | 1 | 1 |
| G2032R | G2032R | 1 | 1 |
| D2033N | D2033N | 1 | 1 |
| I1039T | I1039T | 1 | 1 |
| rs1799793 | rs1799793 | 1 | 1 |
| rs13181 | rs13181 | 1 | 1 |
| rs25487 | rs25487 | 1 | 1 |
| rs861539 | rs861539 | 1 | 1 |
| rs1801131 | rs1801131 | 1 | 1 |
| T1232A | T1232A | 1 | 1 |
| p.Glu709X | p.Glu709X | 1 | 1 |
| p.Gly719X | p.Gly719X | 1 | 1 |
| p.Ser768Ile | p.Ser768Ile | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026Comparative anti-cancer properties of carene isoforms induced apoptotic cell death in stomach and lung cancer cell lines.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026CRISPR-Edited Cell Lines: A New Era in Functional Oncology Research.Current pharmaceutical design1 mentions
- 2026KRASG12D/G13D-USP15 axis promotes TGF-β/SMAD signaling and glycolytic flux to accelerate NSCLC pathogenesis.Lung cancer (Amsterdam, Netherlands)1 mentions
- 2026Pharmacophore-guided review of EGFR-targeted anticancer drugs with gefitinib as a reference.European journal of medicinal chemistry1 mentions
- 2026Real-world adoption of off-label combinations for targeted therapy resistance in non-small cell lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico1 mentions
- 2026Chitosan-functionalized mesoporous silica nanoparticles co-loaded with chrysin and quercetin: a potent strategy against lung cancer cells.Scientific reports1 mentions
- 2026Exploring structural diversity and dynamic stability of small-molecule PRMT5 inhibitors through machine learning-based QSAR and molecular modelling.Molecular diversity1 mentions
- 2026Integrating multiomics data using a correlation based graph attention network for subtype classification in lower grade glioma.Discover oncology1 mentions
- 2026The role of microRNAs in modulating Wnt signaling pathway dynamics and their therapeutic implications in non-small cell lung cancer.Discover oncology1 mentions
- 2026Clinical validation of lightweight CNN architectures for reliable multi-class classification of lung cancer using histopathological imaging techniques.Scientific reports1 mentions
- 2026Profound alterations of cancer transcriptomes by the RNase L inhibitor ABCE1 through the modulation of UU/UA-dinucleotide rich transcript abundance.RNA biology1 mentions
- 2026Identifying regulatory driver motifs in non-small cell lung carcinoma via a systematic approach.PloS one1 mentions
- 2026Transcriptomic and multi-layer variant analysis identifies STAT3 and HIF1A as central regulators of regulated cell death pathways in lung squamous cell carcinoma.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026Smoking-dependent circulating non-coding biomarkers in lung cancer.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2026Molecular Docking and MD Modeling Techniques for the Development of Novel ROS1 Kinase Inhibitors.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2026Reprogramming resistance in advanced lung cancer: epigenetic modulation to restore therapeutic vulnerability.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico1 mentions
- 2026The global cancer crisis: a review of growing burden, deepening inequality and initiatives for prevention and early detection.Ecancermedicalscience1 mentions
- 2026Medicinal Chemistry of Fourth-generation Tyrosine Kinase Inhibitors.Mini reviews in medicinal chemistry1 mentions
- 2026Explainable deep learning-based lung cancer diagnosis using clinically-guided local interpretable model-agnostic explanations.Scientific reports1 mentions
- 2026A multi-stage computational pipeline for repurposing FDA-approved drugs: application to EGFR C797S-mutant NSCLC.Frontiers in chemistry1 mentions
- 2026Green-synthesized CdTe quantum dots: dual-action nanomaterials tackling antimicrobial resistance and cancer.RSC advances1 mentions
- 2026Decoding Prognostic Signatures in Brain Metastatic Non-Small-Cell Lung Cancer via Integrated Multi-Omics and Network Analysis.International journal of molecular sciences1 mentions
- 2026Evaluating the ability of generative AI to standardize TNM staging data in lung cancer.Seminars in oncology1 mentions
- 2026Functional and mechanistic inactivation of immune hubs orchestrates tumor development and progression in lung adenocarcinoma.Discover oncology1 mentions
- 2026Circulating CHI3L1/YKL-40 in lung cancer: Biomarker potential, analytical challenges, and clinical translation prospects.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2026Efficient Estimation Methods for the QR Distribution with Type-II Censored Data: An Empirical Validation on Lung Cancer Prognosis.Entropy (Basel, Switzerland)1 mentions
- 2026Exploring hypoxia-related genes as prognostic indicators in lung adenocarcinoma.PloS one1 mentions
- 2026Immune Landscape and Tumour Heterogeneity in Ovarian Cancer: Insights From Single-Cell RNA Sequencing.Journal of cellular and molecular medicine1 mentions
- 2026Evaluation of PD-L1 Expression and Systemic Inflammatory Blood Cell Ratios as Prognosticators in Advanced Lung, Breast and Head and Neck Cancers.Cancers1 mentions
- 2026Synthesis and multilevel evaluation of benzimidazole-based anticancer compounds: DNA/serum albumin interaction, and in-depth theoretical insights.Molecular and cellular biochemistry1 mentions
- 2026Germline variants and impact on lung cancer outcomes following chemotherapy: A systematic review.Critical reviews in oncology/hematology1 mentions
- 2026From Mechanisms to Therapeutic Innovation in Non-Small Cell Lung Cancer: A Knowledge-Depth Translational Mapping with Experimental Validation.International journal of molecular sciences1 mentions
- 2026Modeling the Effects of Single Nucleotide Polymorphisms (SNPs) on the Structure and Function of the Human RET Gene: An In Silico Study.Human mutation1 mentions
- 2026Identification of selective N-pyridinsulfonyl indole based thiosemicarbazone derivatives as potential antiproliferative agents against lung cancer cells.RSC advances1 mentions
- 2026Heptapharmacological activity of Quercetin-3-O-phosphate against lung cancer pathways.PloS one1 mentions
- 2025The use of Isoflavones as Lung Cancer Chemoprevention Agents and their Implications in Treatment through Radio Sensitization.Current medicinal chemistry1 mentions
- 2025The implication of microbiome in lungs cancer: mechanisms and strategies of cancer growth, diagnosis and therapy.Critical reviews in microbiology1 mentions
- 2025Investigating the chemo-preventive role of noscapine in lung carcinoma via therapeutic targeting of human aurora kinase B.Molecular and cellular biochemistry1 mentions
- 2025Immunotherapy plus Chemotherapy for Patients with EGFR-Mutated Non-Squamous Cell Lung Cancer for Disease Progression after EGFR Tyrosine-Kinase Inhibitor: A Meta-Analysis of Randomized Controlled Trials.Oncology1 mentions
- 2025Investigating the antioxidant and anticancer potential of Daucus spp. extracts against human prostate cancer cell line C4-2, and lung cancer cell line A549.Journal of ethnopharmacology1 mentions
- 2025Exosomal ncRNAs in liquid biopsies for lung cancer.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2025Unraveling the Ferroptosis-inducing Potential of Methanol Leaves Extract of Prosopis Juliflora Via Downregulation of SLC7A11 and GPX4 mRNA Expression in A549 Lung Cancer Cells.Current medicinal chemistry1 mentions
- 2025Comprehensive analysis and outcomes of hybridization of physiologically active heterocycles targeting epidermal growth factor receptor (EGFR).Computers in biology and medicine1 mentions
- 2025Reprogramming tumor-associated macrophages: The role of MEK-STAT3 inhibition in lung cancer.Pathology, research and practice1 mentions
- 2025Betanin inspired zinc oxide nanoparticles: The potential antioxidant and anticancer activity against human lung cancer cell line (A549).Biochemical and biophysical research communications1 mentions
- 2025Unveiling the mechanism of sericin and hydroxychloroquine in suppressing lung oxidative impairment and early carcinogenesis in diethylnitrosamine-induced mice by modulating PI3K/Akt/Nrf2/NF-κB signaling pathway.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie1 mentions
- 2025Liquid mosquito repellent induces toxic effects in zebrafish.Drug and chemical toxicology1 mentions
- 2025Epidermal growth factor receptors unveiled: a comprehensive survey on mutations, clinical insights of global inhibitors, and emergence of heterocyclic derivatives as EGFR inhibitors.Journal of drug targeting1 mentions
- 2025Cellular plasticity and non-small cell lung cancer: role of T and NK cell immune evasion and acquisition of resistance to immunotherapies.Cancer metastasis reviews1 mentions
- 2025Molecular mechanisms of phytoconstituents from selected Egyptian plants against non-small cell lung cancer using integrated in vitro network pharmacology and molecular docking approach.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2025The incidence of venous thromboembolism by type of solid cancer worldwide: A systematic review.Cancer epidemiology1 mentions
- 2025A Computational Recognition Analysis of Promising Prognostic Biomarkers in Breast, Colon and Lung Cancer Patients.International journal of molecular sciences1 mentions
- 2025Deciphering the anticancer potential of thymoquinone: in-depth exploration of the potent flavonoid from Nigella sativa.Molecular biology reports1 mentions
- 2025miR-210: A non-invasive biomarker for hypoxia-driven lung cancer diagnosis and therapy.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2025An innovative approach to development of new pyrazolylquinolin-2-one hybrids as dual EGFR and BRAFV600E inhibitors.Molecular diversity1 mentions
- 2025Leveraging deep learning for epigenetic protein prediction: a novel approach for early lung cancer diagnosis and drug discovery.Health information science and systems1 mentions
- 2025Tumor-educated platelets in lung cancer.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2025Targeting KRAS-G12C in lung cancer: The emerging role of PROTACs in overcoming resistance.Pathology, research and practice1 mentions
- 2025The role of Wnt/β-catenin signaling in lung cancer progression and therapy: a comprehensive review.Medical oncology (Northwood, London, England)1 mentions
- 2025Electric-Field Molecular Fingerprinting to Probe Cancer.ACS central science1 mentions
- 2025Marine-Inspired Spirooxindole PIM-1 Kinase Inhibitors Endowed with Concomitant TRKA/CDK2 Inhibition for Multifaceted Non-Small Cell Lung Cancer Apoptotic Induction.ChemMedChem1 mentions
- 2025Cigarette smoke modulates methylation levels of LEF1-AS1 and impedes its expression: An experimental study.Tobacco induced diseases1 mentions
- 2025Exploring the Profiles of ROS1 Tyrosine Kinase: A Structural Analysis of G2032R and D2033N Mutations.International journal of applied & basic medical research1 mentions
- 2025Design and Synthesis of New pyrazole Hybrids Linked to Oxime and Nitrate Moieties as COX-2, EGFRL858R/T790M Inhibitors and Nitric Oxide Donors with dual Anti-inflammatory/Anti-proliferative Activities.Bioorganic chemistry1 mentions
- 2025Synthesis of Marine-Inspired Multifaceted DNA Damaging Spirooxindoles Combating NSCLC and Associated Bacterial Infection.ACS medicinal chemistry letters1 mentions
- 2025In vivo and in vitro therapeutic evaluation of bone marrow-derived mesenchymal stem cells in liver cancer treatment.Frontiers in cell and developmental biology1 mentions
- 2025Rare aggressive presentation of primary cutaneous diffuse large B-Cell lymphoma, leg type, in the upper arm with concurrent non-small cell lung cancer.BMJ case reports1 mentions
- 2025Unlocking the Molecular Targets in Non-Small-Cell Lung Cancer and a Nanomedicine-Based Remedy.Critical reviews in therapeutic drug carrier systems1 mentions
- 2025An overview of lncRNA GAPLINC's role in human cancer growth and metastasis.Archives of biochemistry and biophysics1 mentions
- 2025Cadherin family genes in non-small cell lung cancer: implications for diagnosis, prognosis, and targeted therapy.American journal of translational research1 mentions
- 2025In vitro antioxidant, anticholinesterase, and antiproliferative activities of methanol extracts of Crateva religiosa bark.Journal of Cancer1 mentions
- 2025From EGFR mutations to STAT30-driven resistance in NSCLC: Biomarkers and multi-modal treatment approach.Pathology, research and practice1 mentions
- 2025Endocrine manifestations of lung adenocarcinoma with epidermal growth factor receptor mutation mimicking tuberculosis: A case report and literature review.Qatar medical journal1 mentions
- 2025Triazole-functionalized benzofuran and benzothiophene semicarbazides as novel VEGFR-2-targeted anti-cancer agents.Bioorganic chemistry1 mentions
- 2025Optimized deep learning approach for lung cancer detection using flying fox optimization and bidirectional generative adversarial networks.PeerJ. Computer science1 mentions
- 2025Chemical Composition and Anti-Lung Cancer Activities of Melaleuca quinquenervia Leaf Essential Oil: Integrating Gas Chromatography-Mass Spectrometry (GC/MS) Profiling, Network Pharmacology, and Molecular Docking.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2025Synthesis and Evaluation of Novel Bis-Chalcone Derivatives Containing a Thiophene Moiety as Potential Anticancer Agents: In Vitro, In Silico , and Mechanistic Studies.ACS omega1 mentions
- 2025AI-driven genetic algorithm-optimized lung segmentation for precision in early lung cancer diagnosis.Scientific reports1 mentions
- 2025Exploring QSPR in breast cancer drugs via entire neighborhood indices and regression models.Scientific reports1 mentions
- 2025Chnoospora minima Polysaccharide-Mediated Green Synthesis of Silver Nanoparticles: Potent Anticancer and Antimicrobial Activities.Biology1 mentions
- 2025The Role of Plant-Derived Natural Products as a Regulator of the Tyrosine Kinase Pathway in the Management of Lung Cancer.Current issues in molecular biology1 mentions
- 2025Isolation, characterization, and biomedical potential of phycoerythrin phycobiliprotein from Kappaphycus alvarezii (Doty) L. M. Liao: antimicrobial, antioxidant, and anticancer activities.Scientific reports1 mentions
- 2025Anticancer Molecular Mechanisms of Epigallocatechin Gallate: An Updated Review on Clinical Trials.Food science & nutrition1 mentions
- 2025Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects.Food science & nutrition1 mentions
- 2025Next-generation nanoformulation: Glycyrrhiza glabra-based chitosan-curcumin MgO/Fe2O3 nanocomposite for targeted lung cancer therapy with dual antioxidant action.Medical oncology (Northwood, London, England)1 mentions
- 2025Targeting the Skp2-Cks1 protein-protein interaction: structures, assays, and preclinical inhibitors.European journal of pharmacology1 mentions
- 2025Prevalence of Molecular Mutations in Non-Small Cell Lung Cancer and Current Treatment Approaches in the MENA Region: Systematic Review and Expert Opinion.Journal of immunotherapy and precision oncology1 mentions
- 2025Integrative proteo-genomic profiling uncovers key biomarkers of lapatinib resistance in HER2-positive breast cancer.British journal of cancer1 mentions
- 2025In silico repurposing of FDA-approved drugs against MEK1: structural and dynamic insights into lung cancer therapeutics.Frontiers in pharmacology1 mentions
- 2025Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management.Food science & nutrition1 mentions
- 2025Ferroptosis-Linked Six-Gene Panel Enables Machine Learning-Assisted Diagnosis and Therapeutic Guidance in Lung Adenocarcinoma.Biology1 mentions
- 2025Long-term Survival in Lung Cancer With Brain Metastases and Coronary Artery Stenosis: A Case Report.Journal of the Saudi Heart Association1 mentions
- 2025Coumarin/nitrogen-bearing heterocyclic hybrid-loaded electrospun PMMA/PVP nanofibrous scaffolds for accelerating topical wound healing rates: synthesis and in vitro bio-evaluation.RSC advances1 mentions
- 2025Thymoquinone Upregulates microRNA-199a-3p and Downregulates COX-2 Expression and PGE2 Production via Deactivation of p38/ERK/JNK-MAPKs and p65/p50-NF-κB Signaling in Human Lung Cancer Cells.Biology1 mentions
- 2025MicroRNA-125b-5p Drives MMP-2 Expression via Activation of RAGE-38MAPK-p65/p50NF-κB Axis: A Novel Mechanism in Human Lung Cancer Cells.International journal of molecular sciences1 mentions
- 2025Butylated Neuropeptide Antagonist Targeting Hypoxia-Induced GRPR Overexpression in Small Cell Lung Cancer.International journal of molecular sciences1 mentions
- 2025Evaluating the Safety and Efficacy of PD-1 Inhibitors in HIV Patients Diagnosed with Lung Cancer: A Systematic Review.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2025Potential Role of Tumor-derived MIF in B-Cell Antigen Presentation in Lung Adenocarcinoma: Single-cell and TCGA Analyses.Anticancer research1 mentions
- 2025QSAR-guided discovery of novel KRAS inhibitors for lung cancer therapy.Frontiers in bioinformatics1 mentions
- 2025Cuproptosis in lung cancer: a nexus of ncRNA regulation, epigenetics, and tumor microenvironment Remodeling.Clinical and experimental medicine1 mentions