61+ results for “CYP1B1”

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CYP1B1

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Gene · 58 articles

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Genetic Risk Factors and Clinical Implications of Glaucoma in the Saudi Population: A Review.

International journal of molecular sciences · 2026 · PMID 42074148 · PubMed ↗ · all extracted evidence

Matches:

CYP1B1 “First, CYP1B1 functions as the dominant causal gene across both primary congenital glaucoma (PCG) and juvenile-onset open-angle glaucoma (JOAG), accounting for 76-86% of cases, with two founder alleles, p.G61E (penetrance 87.7%) and p.R469W (penetrance 93%), driving severe, early-onset phenotypes.”

MYOC “Critically, MYOC and LTBP2, the primary JOAG genes in other populations, carry no pathogenic variants in Saudi cohorts, rendering standard multi-ethnic gene panels inadequate for this population.”

Pathogenic variants identification in primary congenital glaucoma patients using whole exome sequencing.

Scientific reports · 2025 · PMID 40169658 · PubMed ↗ · all extracted evidence

Matches:

CYP1B1 “A prioritization strategy was employed to identify variants in known PCG-related genes, primarily focusing on CYP1B1.”

primary congenital glaucoma “Pathogenic variants identification in primary congenital glaucoma patients using whole exome sequencing.”

Integrated Network Pharmacology, Molecular Modeling, LC-MS Profiling, and Semisynthetic Approach for the Roots of Rubia tinctorum L. Metabolites in Cancer Treatment.

ACS omega · 2025 · PMID 40224436 · PubMed ↗ · all extracted evidence

Matches:

CYP1B1 “The most enriched cancer-linked target genes were PLCG1, BCL2, CYP1B1, NSD2, and ESR2.”

PLCG1 “The most enriched cancer-linked target genes were PLCG1, BCL2, CYP1B1, NSD2, and ESR2.”

Identification of Novel Genes and Pathways of Ovarian Cancer Using a Comprehensive Bioinformatic Framework.

Applied biochemistry and biotechnology · 2024 · PMID 37615851 · PubMed ↗ · all extracted evidence

Matches:

CYP1B1 “The study identified a total of five genes (CDKN1A, DKK1, CYP1B1, NTS, and GDF15) that were differentially expressed in OC.”

CDKN1A “The study identified a total of five genes (CDKN1A, DKK1, CYP1B1, NTS, and GDF15) that were differentially expressed in OC.”

Genetic heterogeneity of primary open-angle glaucoma in Pakistan.

Saudi journal of biological sciences · 2023 · PMID 36387029 · PubMed ↗ · all extracted evidence

Matches:

CYP1B1 “The present study has been conducted to screen 25 POAG families with 2 or more affected members for their association with Myoc and CYP1B1 (the most common gene in primary congenital glaucoma).”

primary congenital glaucoma “The present study has been conducted to screen 25 POAG families with 2 or more affected members for their association with Myoc and CYP1B1 (the most common gene in primary congenital glaucoma).”

Genetic Epidemiology of Primary Congenital Glaucoma in the 22 Arab Countries: A Systematic Review.

Ophthalmic epidemiology · 2022 · PMID 33641569 · PubMed ↗ · all extracted evidence

Matches:

CYP1B1 “Variants in CYP1B1 gene are the most encountered in PCG cases.”

MYOC “Sixty-nine variants were identified in the CYP1B1 gene, five variants were in the MYOC gene and single variants were reported in NTF4, FOXC1, and WDR36 genes.”

Mutational analysis of CYP1B1 (rs56010818) variant in primary open angle glaucoma (POAG) affected patients of Pakistan.

Saudi journal of biological sciences · 2022 · PMID 35002398 · PubMed ↗ · all extracted evidence

Matches:

CYP1B1 “Mutational analysis of CYP1B1 (rs56010818) variant in primary open angle glaucoma (POAG) affected patients of Pakistan.”

rs56010818 “Mutational analysis of CYP1B1 (rs56010818) variant in primary open angle glaucoma (POAG) affected patients of Pakistan.”

The Antioxidative Role of Natural Compounds from a Green Coconut Mesocarp Undeniably Contributes to Control Diabetic Complications as Evidenced by the Associated Genes and Biochemical Indexes.

Oxidative medicine and cellular longevity · 2021 · PMID 34367469 · PubMed ↗ · all extracted evidence

Matches:

CYP1B1 “Of the top 15 proteins found by Cytoscape 3.6.1, 8, CAT and OGG1 (downregulated) and CASP3, COMT, CYP1B1, DPYD, NQO1, and PTGS1 (upregulated), were dysregulated in diabetes-related kidney disease.”

OGG1 “Of the top 15 proteins found by Cytoscape 3.6.1, 8, CAT and OGG1 (downregulated) and CASP3, COMT, CYP1B1, DPYD, NQO1, and PTGS1 (upregulated), were dysregulated in diabetes-related kidney disease.”

Biological and Clinical Implications of TNF-α Promoter and CYP1B1 Gene Variations in Coronary Artery Disease Susceptibility.

Cardiovascular & hematological disorders drug targets · 2021 · PMID 34939556 · PubMed ↗ · all extracted evidence

Matches:

CYP1B1 “Biological and Clinical Implications of TNF-α Promoter and CYP1B1 Gene Variations in Coronary Artery Disease Susceptibility.”

coronary artery disease “Biological and Clinical Implications of TNF-α Promoter and CYP1B1 Gene Variations in Coronary Artery Disease Susceptibility.”

Meta-analysis of CYP1B1 gene mutations in primary congenital glaucoma patients.

European journal of ophthalmology · 2021 · PMID 34020567 · PubMed ↗ · all extracted evidence

Matches:

CYP1B1 “Meta-analysis of CYP1B1 gene mutations in primary congenital glaucoma patients.”

primary congenital glaucoma “Meta-analysis of CYP1B1 gene mutations in primary congenital glaucoma patients.”

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