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PMID 35619874 | PMCID PMC9124608 | DOI 10.7759/cureus.24392 · Cureus · 2022 · 6 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
variant	p.G12D	“KRAS p.G12D accounted for the most frequently resulting variant (17/42, 40.5%).”	0.95	hgvs_regex_v1
gene	KRAS	“KRAS/NRAS/BRAF Mutation Rate in Saudi Academic Hospital Patients With Colorectal Cancer.”	0.98	hgnc_dict_v1
gene	NRAS	“KRAS/NRAS/BRAF Mutation Rate in Saudi Academic Hospital Patients With Colorectal Cancer.”	0.98	hgnc_dict_v1
gene	BRAF	“KRAS/NRAS/BRAF Mutation Rate in Saudi Academic Hospital Patients With Colorectal Cancer.”	0.98	hgnc_dict_v1

PMID 32983680 | PMCID PMC7511070 | DOI 10.7759/cureus.9978 · Cureus · 2020 · 4 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
variant	p.G12D	“Seventy-five percent of these K-ras mutations were in codon 12, most commonly p.G12D.”	0.95	hgvs_regex_v1
phenotype	colorectal cancer	“Background Colorectal cancer (CRC) is one of the leading types of cancer worldwide and in Saudi Arabia.”	0.98	phenotype_alias_lexicon_v2
population	Saudi Arabia, Madinah	“Clinico-Pathological Study of K-ras Mutations in Colorectal Tumors: A Single-Center Retrospective Study of 51 Patients in Madinah, Saudi Arabia. Background Colorectal cancer (CRC) is one of the leading types of cancer worldwide and in Saudi Arabia. Methods Medical records and paraffin-embedded tumor samples from 51 patients with histologically proven colorectal adenocarcinoma referred to Madinah center in Saudi Arabia were analyzed for the occurrence of rat sarcoma virus (RAS) mutations. Conclusions K-ras mutations are common among Saudi patients diagnosed with CRC in Madinah, especially pG12V and pG12D in codon 12.”	0.95	saudi_context_rules_v1
variant	p.G13D	“Codon 13 mutations occurred in 20% of tumors: all of these were p.G13D (100%).”	0.95	hgvs_regex_v1

PMID 24675495 | DOI 10.1700/1430.15819 · Tumori · 2014 · 6 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
variant	p.G12D	“RESULTS: K-ras mutations occurred in 56% of the patients; 48.7% of the mutations were in codon 12, most commonly p.G12V and p.G12D (each 35.6% of codon 12 mutations).”	0.95	hgvs_regex_v1
phenotype	colorectal cancer	“AIMS AND BACKGROUND: K-ras gene mutations contribute to the pathogenesis of colorectal cancer.”	0.98	phenotype_alias_lexicon_v2
population	Saudi Arabia	“Clinico-pathological study of K-ras mutations in colorectal tumors in Saudi Arabia. We characterized K-ras mutations in colorectal tumors in patients in the Kingdom of Saudi Arabia, in terms of geographic area, age, gender, histology, stage, and anatomical localization. METHODS: Medical records and paraffin-embedded tumor samples from 150 consecutive patients with histologically proven colorectal adenocarcinoma referred to two centers in Saudi Arabia were analyzed using an LCD-array kit. CONCLUSIONS: K-ras mutations are common among the Saudi colorectal cancer population, especially pG12V and pG12D in codon 12, and are more frequent in sigmoid and rectal adenocarcinomas and stage IVB tumors.”	0.95	saudi_context_rules_v1
variant	p.G12V	“RESULTS: K-ras mutations occurred in 56% of the patients; 48.7% of the mutations were in codon 12, most commonly p.G12V and p.G12D (each 35.6% of codon 12 mutations).”	0.95	hgvs_regex_v1