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3 records shown · first 60Evaluating the Impact of rs4025935, rs71748309, rs699947, and rs4646994 Genetic Determinants on Polycystic Ovary Syndrome Predisposition-A Case-Control Study.
PMID 40283113 | PMCID PMC12028387 | DOI 10.3390/life15040558 · Life (Basel, Switzerland) · 2025 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4025935 | “Evaluating the Impact of rs4025935, rs71748309, rs699947, and rs4646994 Genetic Determinants on Polycystic Ovary Syndrome Predisposition-A Case-Control Study.” | 0.90 | hgvs_regex_v1 |
| gene | GSTM1 | “Thus, this study aims to investigate the association of a glutathione S-transferase M1 (GSTM1) deletion, VEGF gene (I/D) insertion/deletion, and VEGF-2578 gene polymorphism with polycystic ovarian syndrome.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “Specifically, regarding the GSTT1 genotype, individuals with the GSTT1-null genotype had an odds ratio (OR) of 4.16 and a relative risk (RR) of 2.14 compared to those with the GSTT1 genotype, with statistically significant differences (p = 0.0001).” | 0.98 | hgnc_dict_v1 |
| phenotype | metabolic syndrome | “It is linked to an increased risk of endometrial cancer, cardiovascular diseases, mental illnesses, non-alcoholic fatty liver disease, metabolic syndrome, and Type 2 diabetes.” | 0.98 | phenotype_alias_lexicon_v2 |
Association of Genetic and Allelic Variants of Von Willebrand Factor (VWF), Glutathione S-Transferase and Tumor Necrosis Factor Alpha with Ischemic Stroke Susceptibility and Progression in the Saudi Population.
PMID 37240845 | PMCID PMC10224221 | DOI 10.3390/life13051200 · Life (Basel, Switzerland) · 2023 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4025935 | “We obtained significant distributions of VWF rs61748511 T > C, TNF-alpha rs1800629 G > A and GST rs4025935 and rs71748309 genotypes between stroke cases and the healthy controls (p < 0.05).” | 0.90 | hgvs_regex_v1 |
| gene | VWF | “Association of Genetic and Allelic Variants of Von Willebrand Factor (VWF), Glutathione S-Transferase and Tumor Necrosis Factor Alpha with Ischemic Stroke Susceptibility and Progression in the Saudi Population.” | 0.98 | hgnc_dict_v1 |
| gene | GSTT1 | “The incidence of ischemic stroke is probably increased by the interaction of GSTT1 and GSTM1 null genotypes with high blood pressure, diabetes and cigarette smoking.” | 0.98 | hgnc_dict_v1 |
| gene | GSTM1 | “The incidence of ischemic stroke is probably increased by the interaction of GSTT1 and GSTM1 null genotypes with high blood pressure, diabetes and cigarette smoking.” | 0.98 | hgnc_dict_v1 |
GSTT1 (rs4025935) null genotype is associated with increased risk of sickle cell disease in the populations of Tabuk-Northwestern region of Saudi Arabia.
PMID 27885941 | DOI 10.1080/10245332.2016.1201631 · Hematology (Amsterdam, Netherlands) · 2017 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4025935 | “GSTT1 (rs4025935) null genotype is associated with increased risk of sickle cell disease in the populations of Tabuk-Northwestern region of Saudi Arabia.” | 0.90 | hgvs_regex_v1 |
| gene | GSTT1 | “GSTT1 (rs4025935) null genotype is associated with increased risk of sickle cell disease in the populations of Tabuk-Northwestern region of Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | GSTM1 | “Present study was, therefore, undertaken to examine the relative impact of the genetic polymorphism of GSTT1 and GSTM1 (rs4025935 and rs71748309) on susceptibility and hematological aspects of the patients with SCD.” | 0.98 | hgnc_dict_v1 |
| phenotype | sickle cell disease | “GSTT1 (rs4025935) null genotype is associated with increased risk of sickle cell disease in the populations of Tabuk-Northwestern region of Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |