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5 records shown · first 60Association of a single nucleotide polymorphism in SOD2 with susceptibility for the development of diabetic nephropathy in patients with type 2 diabetes: A Saudi population study.
PMID 37698290 | PMCID PMC10638619 | DOI 10.1002/edm2.449 · Endocrinology, diabetes & metabolism · 2023 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4880 | “This study aimed to investigate the potential association between single nucleotide polymorphisms (SNPs) in antioxidant enzymes, specifically SOD2 rs4880 and CAT rs769217, and the risk of T2D and susceptibility to DN within the Saudi population.” | 0.90 | hgvs_regex_v1 |
| gene | SOD2 | “Association of a single nucleotide polymorphism in SOD2 with susceptibility for the development of diabetic nephropathy in patients with type 2 diabetes: A Saudi population study.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Association of a single nucleotide polymorphism in SOD2 with susceptibility for the development of diabetic nephropathy in patients with type 2 diabetes: A Saudi population study.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | renal failure | “INTRODUCTION: One of the complications of diabetes mellitus (DM) is diabetic nephropathy (DN), which plays a significant role in the progression of end-stage renal disease.” | 0.93 | phenotype_alias_lexicon_v2 |
Association SOD2 and PON1 Gene Polymorphisms with Polycystic Ovary Syndrome in Saudi Women.
PMID 35414808 | PMCID PMC8928176 | DOI 10.1159/000519527 · Molecular syndromology · 2022 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4880 | “In this study, we investigate the associations between superoxide dismutase 2 (SOD2) (rs4880) and paraoxonase 1 (PON1) (rs705379) polymorphisms in PCOS in Saudi women.” | 0.90 | hgvs_regex_v1 |
| gene | SOD2 | “Association SOD2 and PON1 Gene Polymorphisms with Polycystic Ovary Syndrome in Saudi Women.” | 0.98 | hgnc_dict_v1 |
| gene | PON1 | “Association SOD2 and PON1 Gene Polymorphisms with Polycystic Ovary Syndrome in Saudi Women.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “Association SOD2 and PON1 Gene Polymorphisms with Polycystic Ovary Syndrome in Saudi Women. In this study, we investigate the associations between superoxide dismutase 2 (SOD2) (rs4880) and paraoxonase 1 (PON1) (rs705379) polymorphisms in PCOS in Saudi women. The study included 99 females with PCOS and 98 healthy women as a control. SOD2 and PON1 polymorphisms may be genetic factors that affect the occurrence of PCOS in Saudi females.” | 0.95 | saudi_context_rules_v1 |
Antioxidants-Related Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPX), Glutathione-S-Transferase (GST), and Nitric Oxide Synthase (NOS) Gene Variants Analysis in an Obese Population: A Preliminary Case-Control Study.
PMID 33924357 | PMCID PMC8070436 | DOI 10.3390/antiox10040595 · Antioxidants (Basel, Switzerland) · 2021 · 14 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4880 | “Six SNPs were significantly more prevalent in obese cohorts: (1) GSTM1 rs1056806*C/T; (2) SOD1 rs2234694*A; (3) SOD2 rs4880*G; (4) SOD3 rs2536512*A; (5) GPX1 rs1800668*A; (6) NOS3 rs1799983*G.” | 0.90 | hgvs_regex_v1 |
| gene | GSTM1 | “Six SNPs were significantly more prevalent in obese cohorts: (1) GSTM1 rs1056806*C/T; (2) SOD1 rs2234694*A; (3) SOD2 rs4880*G; (4) SOD3 rs2536512*A; (5) GPX1 rs1800668*A; (6) NOS3 rs1799983*G.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Six SNPs were significantly more prevalent in obese cohorts: (1) GSTM1 rs1056806*C/T; (2) SOD1 rs2234694*A; (3) SOD2 rs4880*G; (4) SOD3 rs2536512*A; (5) GPX1 rs1800668*A; (6) NOS3 rs1799983*G.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Six SNPs were significantly more prevalent in obese cohorts: (1) GSTM1 rs1056806*C/T; (2) SOD1 rs2234694*A; (3) SOD2 rs4880*G; (4) SOD3 rs2536512*A; (5) GPX1 rs1800668*A; (6) NOS3 rs1799983*G.” | 0.98 | hgnc_dict_v1 |
Association of SOD2 Mutation (c.47T > C) with Various Primary Angle Closure Glaucoma Clinical Indices.
PMID 24070129 | DOI 10.3109/13816810.2013.838276 · Ophthalmic genetics · 2015 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4880 | “We investigated whether the c.47T>C polymorphism (SNP rs4880) in the manganese superoxide dismutase (SOD2) gene is a risk factor for primary angle closure glaucoma (PACG) in the Saudi population.” | 0.90 | hgvs_regex_v1 |
| gene | SOD2 | “Association of SOD2 Mutation (c.47T > C) with Various Primary Angle Closure Glaucoma Clinical Indices.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “We investigated whether the c.47T>C polymorphism (SNP rs4880) in the manganese superoxide dismutase (SOD2) gene is a risk factor for primary angle closure glaucoma (PACG) in the Saudi population.” | 0.95 | saudi_context_rules_v1 |
| variant | c.47T>C | “We investigated whether the c.47T>C polymorphism (SNP rs4880) in the manganese superoxide dismutase (SOD2) gene is a risk factor for primary angle closure glaucoma (PACG) in the Saudi population.” | 0.95 | hgvs_regex_v1 |
Association of Mn-SOD mutation (c.47T > C) with various POAG clinical indices.
PMID 23647424 | DOI 10.3109/13816810.2013.796390 · Ophthalmic genetics · 2014 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs4880 | “MATERIALS AND METHODS: A cohort of 226 unrelated POAG patients and 403 unrelated control subjects from Saudi Arabia were genotyped for a single nucleotide polymorphism (SNP; rs4880; c.47T > C) utilizing Taq-Man® assay ID: C_8709053_10.” | 0.90 | hgvs_regex_v1 |
| population | Saudi Arabia | “BACKGROUND: To investigate whether the c.47T > C mutation in the manganese superoxide dismutase gene (Mn-SOD) is a risk factor for primary open angle glaucoma (POAG) in the Saudi population. MATERIALS AND METHODS: A cohort of 226 unrelated POAG patients and 403 unrelated control subjects from Saudi Arabia were genotyped for a single nucleotide polymorphism (SNP; rs4880; c.47T > C) utilizing Taq-Man® assay ID: C_8709053_10.” | 0.95 | saudi_context_rules_v1 |