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2 records shown · first 60A study on the immunological vitality of an inflammatory biomarker explored with rs5743708 polymorphism in TLR2 gene among Saudi women confirmed with polycystic ovarian syndrome.
PMID 37485450 | PMCID PMC10362453 | DOI 10.1016/j.sjbs.2023.103687 · Saudi journal of biological sciences · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs5743708 | “A study on the immunological vitality of an inflammatory biomarker explored with rs5743708 polymorphism in TLR2 gene among Saudi women confirmed with polycystic ovarian syndrome.” | 0.90 | hgvs_regex_v1 |
| gene | TLR2 | “A study on the immunological vitality of an inflammatory biomarker explored with rs5743708 polymorphism in TLR2 gene among Saudi women confirmed with polycystic ovarian syndrome.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Toll-like receptor 2 (TLR2) gene was linked to PCOS and chronic inflammation, and the prevalence of obesity was rising in Saudi women.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “A study on the immunological vitality of an inflammatory biomarker explored with rs5743708 polymorphism in TLR2 gene among Saudi women confirmed with polycystic ovarian syndrome. Toll-like receptor 2 (TLR2) gene was linked to PCOS and chronic inflammation, and the prevalence of obesity was rising in Saudi women. AIM: In this study, we investigated the molecular role of rs5743708 polymorphism in TLR2 gene among Saudi women diagnosed with PCOS using the Rotterdam criteria. METHODS: Blood samples were collected from 220 Saudi women in this hospital-based case-control study; 110 were PCOS women and remaining 110 were non-PCOS (control women). CONCLUSION: The rs5743708 polymorphism was not associated to PCOS in Saudi women.” | 0.95 | saudi_context_rules_v1 |
Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.
PMID 23289617 | DOI 10.1089/gtmb.2012.0281 · Genetic testing and molecular biomarkers · 2013 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs5743708 | “Two polymorphisms located in the TLR2 gene (Pro631His and Arg753Gln, rs5743704 and rs5743708, respectively), and two (Asp299Gly and Thr399Ile, rs4986790 and rs4986791, respectively), located in the TLR4 gene have been genotyped in 201 unrelated individuals from Saudi Arabia.” | 0.90 | hgvs_regex_v1 |
| gene | TLR2 | “Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.” | 0.98 | hgnc_dict_v1 |
| gene | TLR4 | “Genetic variation of TLR2 and TLR4 among the Saudi Arabian population: insight into the evolutionary dynamics of the Arabian Peninsula.” | 0.98 | hgnc_dict_v1 |
| phenotype | malaria | “Considering the reported protective role of these polymorphisms against malaria, the data suggest that the regional variation at these gene loci could have been shaped by both evolutionary infection pressure and bidirectional human migrations in the past.” | 0.98 | phenotype_alias_lexicon_v2 |