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2 records shown · first 60BDNF Val66Met Variant as a Genetic Risk Factor for Major Depressive Disorder in Saudis.
PMID 41631468 | DOI 10.1177/19450265261419292 · Genetic testing and molecular biomarkers · 2026 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs6265 | “The Val66Met polymorphism (rs6265), involving the substitution of valine (Val, G allele) with methionine (Met, A allele), impairs activity-dependent BDNF secretion.” | 0.90 | hgvs_regex_v1 |
| gene | BDNF | “BDNF Val66Met Variant as a Genetic Risk Factor for Major Depressive Disorder in Saudis.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “OBJECTIVE: Major depressive disorder (MDD) is a prevalent and disabling psychiatric condition in Saudi Arabia, with genetic susceptibility remaining incompletely characterized. This study examined the frequency of Val66Met and its association with MDD in a Saudi cohort. MATERIALS AND METHODS: A case-control study was conducted, including 87 patients with MDD (44 males, 43 females; mean age 44.2 ± 11.5 years) and 87 healthy controls (39 males, 48 females; mean age 28.7 ± 8.4 years).” | 0.95 | saudi_context_rules_v1 |
Association between the Val66Met polymorphism (rs6265/G196A) of the BDNF gene and cognitive performance with SSRI use in Arab Alzheimer's disease patients.
PMID 35002376 | PMCID PMC8720700 | DOI 10.1016/j.jsps.2021.10.007 · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs6265 | “Association between the Val66Met polymorphism (rs6265/G196A) of the BDNF gene and cognitive performance with SSRI use in Arab Alzheimer's disease patients.” | 0.90 | hgvs_regex_v1 |
| gene | BDNF | “Association between the Val66Met polymorphism (rs6265/G196A) of the BDNF gene and cognitive performance with SSRI use in Arab Alzheimer's disease patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Association between the Val66Met polymorphism (rs6265/G196A) of the BDNF gene and cognitive performance with SSRI use in Arab Alzheimer's disease patients.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Healthy young, middle ages (25-59 years old) and elderly (more than 60 years old) participants (140) as well as 40 AD patients of whom are both of Saudi Arabian origin were recruited.” | 0.95 | saudi_context_rules_v1 |