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2 records shown · first 60Lack of association between fat mass and obesity-associated genetic variant (rs8050136) and type 2 diabetes mellitus.
PMID 35110337 | PMCID PMC9127913 | DOI 10.15537/smj.2022.43.2.20210822 · Saudi medical journal · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs8050136 | “Lack of association between fat mass and obesity-associated genetic variant (rs8050136) and type 2 diabetes mellitus.” | 0.90 | hgvs_regex_v1 |
| gene | FTO | “OBJECTIVES: To study the genotype and allele frequency of the fat mass and obesity-associated (FTO) rs8050136 A>C genetic variant and investigate its association with type 2 diabetes mekkitus (T2DM) parameters.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Lack of association between fat mass and obesity-associated genetic variant (rs8050136) and type 2 diabetes mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia, Madinah | “METHODS: This study was carried out on 118 diabetic patients and 106 healthy individuals (control) from Prince Mohammed bin Abdulaziz Hospital, Al Madinah Al Munawarah, Saudi Arabia. CONCLUSION: Our findings show that the FTO rs8050136 A>C variant is not associated with T2DM in the Saudi population.” | 0.95 | saudi_context_rules_v1 |
Polycystic ovary syndrome is linked with the fat mass obesity (FTO) gene variants rs17817449 and rs1421085 in western Saudi Arabia.
PMID 35655906 | PMCID PMC9148595 | DOI 10.6026/97320630017904 · Bioinformation · 2021 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | rs8050136 | “Therefore, it is of interest to determine the genotype and allele frequency for three FTO variants - rs17817449 (G/T), rs1421085 (C/T) and rs8050136 (A/C) -in western Saudi population.” | 0.90 | hgvs_regex_v1 |
| gene | FTO | “Polycystic ovary syndrome is linked with the fat mass obesity (FTO) gene variants rs17817449 and rs1421085 in western Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Polycystic ovary syndrome is linked with the fat mass obesity (FTO) gene variants rs17817449 and rs1421085 in western Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | infertility | “Polycystic ovary syndrome (PCOS) is characterised by infertility, obesity, insulin resistance and clinical and/or biochemical signs of hyperandrogenism.” | 0.98 | phenotype_alias_lexicon_v2 |