obesity
HP:0001513 · SaudiVarKB evidence summary derived from retained literature mentions.
762Phenotype mentions
100Publications
50Associated gene records
50Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| FTO | HGNC:24678 | 21 | 21 |
| MC4R | HGNC:6932 | 11 | 11 |
| FAS | HGNC:11920 | 7 | 7 |
| ADIPOQ | HGNC:13633 | 7 | 7 |
| TG | HGNC:11764 | 6 | 6 |
| MTHFR | HGNC:7436 | 6 | 6 |
| VDR | HGNC:12679 | 6 | 6 |
| UCP1 | HGNC:12517 | 6 | 6 |
| LEP | HGNC:6553 | 6 | 6 |
| ACE2 | HGNC:13557 | 6 | 6 |
| NLRP3 | HGNC:16400 | 5 | 5 |
| TCF7L2 | HGNC:11641 | 5 | 5 |
| ACE | HGNC:2707 | 5 | 5 |
| SIRT1 | HGNC:14929 | 4 | 4 |
| TNF | HGNC:11892 | 4 | 4 |
| KLF14 | HGNC:23025 | 4 | 4 |
| LDLR | HGNC:6547 | 4 | 4 |
| TP53 | HGNC:11998 | 4 | 4 |
| DNMT1 | HGNC:2976 | 4 | 4 |
| SOD2 | HGNC:11180 | 4 | 4 |
| TLR2 | HGNC:11848 | 4 | 4 |
| FABP4 | HGNC:3559 | 4 | 4 |
| LEPR | HGNC:6554 | 4 | 4 |
| LPL | HGNC:6677 | 3 | 3 |
| CYP21A2 | HGNC:2600 | 3 | 3 |
| SOD1 | HGNC:11179 | 3 | 3 |
| CRP | HGNC:2367 | 3 | 3 |
| GIPR | HGNC:4271 | 3 | 3 |
| VEGFA | HGNC:12680 | 3 | 3 |
| ALMS1 | HGNC:428 | 3 | 3 |
| EGFR | HGNC:3236 | 3 | 3 |
| TLR4 | HGNC:11850 | 3 | 3 |
| GSTM1 | HGNC:4632 | 3 | 3 |
| MYC | HGNC:7553 | 3 | 3 |
| CD14 | HGNC:1628 | 3 | 3 |
| HIF3A | HGNC:15825 | 3 | 3 |
| FGF21 | HGNC:3678 | 3 | 3 |
| PRDM16 | HGNC:14000 | 3 | 3 |
| CPT1A | HGNC:2328 | 2 | 2 |
| CCL5 | HGNC:10632 | 2 | 2 |
| BDNF | HGNC:1033 | 2 | 2 |
| PPARG | HGNC:9236 | 2 | 2 |
| STAT3 | HGNC:11364 | 2 | 2 |
| SOD3 | HGNC:11181 | 2 | 2 |
| HMOX1 | HGNC:5013 | 2 | 2 |
| ABCB1 | HGNC:40 | 2 | 2 |
| PTGS2 | HGNC:9605 | 2 | 2 |
| FOS | HGNC:3796 | 2 | 2 |
| BRCA1 | HGNC:1100 | 2 | 2 |
| PTH | HGNC:9606 | 2 | 2 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| rs9939609 | rs9939609 | 8 | 8 |
| rs1544410 | rs1544410 | 3 | 3 |
| rs731236 | rs731236 | 3 | 3 |
| C677T | C677T | 2 | 2 |
| rs12970134 | rs12970134 | 2 | 2 |
| rs17782313 | rs17782313 | 2 | 2 |
| rs2228570 | rs2228570 | 2 | 2 |
| rs5743708 | rs5743708 | 2 | 2 |
| rs7903146 | rs7903146 | 2 | 2 |
| rs11642841 | rs11642841 | 2 | 2 |
| rs4240157 | rs4240157 | 2 | 2 |
| rs17817449 | rs17817449 | 2 | 2 |
| rs7799039 | rs7799039 | 2 | 2 |
| rs1137101 | rs1137101 | 2 | 2 |
| rs1800436 | rs1800436 | 1 | 1 |
| rs1800437 | rs1800437 | 1 | 1 |
| rs2302382 | rs2302382 | 1 | 1 |
| rs10423928 | rs10423928 | 1 | 1 |
| rs34125392 | rs34125392 | 1 | 1 |
| A1298C | A1298C | 1 | 1 |
| c.2729C>G | c.2729C>G | 1 | 1 |
| p.Ser910* | p.Ser910* | 1 | 1 |
| c.94C>T | c.94C>T | 1 | 1 |
| p.Gln32Ter | p.Gln32Ter | 1 | 1 |
| c.160A>T | c.160A>T | 1 | 1 |
| p.Lys54Ter | p.Lys54Ter | 1 | 1 |
| c.720C>A | c.720C>A | 1 | 1 |
| p.Cys240Ter | p.Cys240Ter | 1 | 1 |
| c.505A>T | c.505A>T | 1 | 1 |
| p.Lys169Ter | p.Lys169Ter | 1 | 1 |
| c.775delA | c.775delA | 1 | 1 |
| c.1339G>A | c.1339G>A | 1 | 1 |
| p.Ala447Thr | p.Ala447Thr | 1 | 1 |
| c.951+1G>A | c.951+1G>A | 1 | 1 |
| c.119C>G | c.119C>G | 1 | 1 |
| p.Ser40* | p.Ser40* | 1 | 1 |
| c.196delA | c.196delA | 1 | 1 |
| rs2107538 | rs2107538 | 1 | 1 |
| rs7903146 | rs7903146 | 1 | 1 |
| rs895819 | rs895819 | 1 | 1 |
| rs11614913 | rs11614913 | 1 | 1 |
| rs972283 | rs972283 | 1 | 1 |
| rs6505162 | rs6505162 | 1 | 1 |
| rs2234693 | rs2234693 | 1 | 1 |
| rs2910164 | rs2910164 | 1 | 1 |
| IVS18 | IVS18 | 1 | 1 |
| rs7975232 | rs7975232 | 1 | 1 |
| rs1642785 | rs1642785 | 1 | 1 |
| rs9894946 | rs9894946 | 1 | 1 |
| rs1042522 | rs1042522 | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026Type 2 Diabetes Mellitus in Saudi Arabia: Prevalence, Risk Factors, and Management Strategies: A Review.Endocrine, metabolic & immune disorders drug targets1 mentions
- 2026Biochemical landscape of breast cancer: integrating serum markers with clinical prognosis and staging.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico1 mentions
- 2026Acute Toxicities of Bone Marrow Donation in Unrelated Donors with Sickle Cell Trait: A Center for International Blood and Marrow Transplantation Research Analysis.Transplantation and cellular therapy1 mentions
- 2026Amylin receptors as therapeutic targets in obesity: Emerging peptide-based strategies.Vascular pharmacology1 mentions
- 2026In Vivo Gastric Expression of FTO and MC4R in Sleeve Gastrectomy Patients: Diagnostic Utility Without Predictive Value for Weight Loss.Obesity surgery1 mentions
- 2026Inflammatory Bowel Disease in Children and Young People Living With Overweight or Obesity: A Critical Narrative Review.Obesity reviews : an official journal of the International Association for the Study of Obesity1 mentions
- 2026Efficacy of omega-3 fatty acids as a functional food: a multifaceted approach to health reinforcement.Journal of the science of food and agriculture1 mentions
- 2026GDF-15 as an integrative cardiometabolic biomarker.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2026Reduced plasma epidermal growth factor levels reflect poor glycaemic status in type 2 diabetes.Endocrine connections1 mentions
- 2026Mitigation of Metabolic Diseases Through Personalized Nutrition: A Critical In-Depth Review.Food science & nutrition1 mentions
- 2026Analysis of Risk Factors and Assessment of miRNA-122 as a Novel Biomarker for Colon Cancer in Egyptian Patients.Asian Pacific journal of cancer prevention : APJCP1 mentions
- 2026Modulatory Role of Moringa Oleifera-Loaded Silver Nanoparticles on UCP1 and PPARGC1A Genes Expression in an Obesity Rat Model.Applied biochemistry and biotechnology1 mentions
- 2026Post-Myocardial Infarction Prognostic Factors and Mortality in the Gulf Region: A Systematic Review and Meta-Analysis.Current cardiology reviews1 mentions
- 2026RNA-Binding Proteins in Adipose Biology: From Mechanistic Understanding to Therapeutic Opportunities.International journal of molecular sciences1 mentions
- 2026Methanimine derivative (BN3) alleviates obesity-associated neurobehavior alteration by influencing metabolic and neuroinflammatory gene pathways in in-vivo zebrafish model.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2026Atypical antipsychotics and metabolic dysfunction-associated steatotic liver disease in children and adolescents: A systematic review.International journal of psychiatry in medicine1 mentions
- 2026Advancing Life Sciences and Biotechnology in Saudi Arabia: A Comprehensive Overview of the Saudi Biobank Project Study Design and Aspirations.Journal of epidemiology and global health1 mentions
- 2026Graphene-based SPR biosensor in octagon-cross-shaped optimized with Au-Ag and SiC ceramic nanomaterials investigation for cancerous cells and single-cell RNA detection.SLAS technology1 mentions
- 2026The Impact of Weight Loss Secondary to Bariatric Surgery on Telomere Biology: A Narrative Review.Biomedicines1 mentions
- 2026Polycystic Ovarian Syndrome (PCOS): A Brief Overview on Pathogenesis, Main Signaling Pathways, and Recent Studies Performed on Letrozole-induced PCOS in Rodents.Current pharmaceutical biotechnology1 mentions
- 2026KCNJ11 (p.Arg192Cys)-associated MODY13 with coexisting autoimmunity in a child, a case report.BMC pediatrics1 mentions
- 2026Effect of walking exercise on liver enzymes in children with phenylketonuria and non-alcoholic fatty liver disease: A randomized controlled trial.Medicina clinica1 mentions
- 2026Congenital adrenal hyperplasia in Saudi Arabia: Epidemiology, genetic mutations, and evolving management strategies.Journal of the National Medical Association1 mentions
- 2026Exploring Adipose Tissue Complexity Through Omics Approaches: Implications for Health and Disease.Cells1 mentions
- 2026Exploring the Epigenetic Mechanisms Underlying Chronic Diseases: A Comprehensive Review.Current gene therapy1 mentions
- 2026Association of Monocyte Chemoattractant Protein-1 and Endothelin-1 Genes with Cardiac Pro-Β-Type Natriuretic Peptide Levels in Obese Hypertensive Patients.Current pharmaceutical design1 mentions
- 2026Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities.Cell metabolism1 mentions
- 2026Proteomic Profiling of Endometrial Cancer Tissues Reveals Differential Expression of Proteomes in Obese Versus Non-Obese Patients.Cells1 mentions
- 2026Traditional cardiovascular risk factors and their association with atherosclerotic cardiovascular disease in homozygous familial hypercholesterolemia: A cross-sectional analysis from the HICC registry.Atherosclerosis1 mentions
- 2026Association of P2Y12 G52T genetic polymorphism with recurrent thromboembolic events in stroke and myocardial infarction patients on clopidogrel therapy: a prospective observational study.Scientific reports1 mentions
- 2026IGF-1 attenuates high fat diet-elicited cardiomyopathy via arachidylcarnitine-dependent suppression of ferroptosis and mitochondrial dysfunction.European journal of pharmacology1 mentions
- 2026Prevalence of Malnutrition Among School-Aged Children With and Without Intellectual and Developmental Disabilities in Saudi Arabia: A Cross-Sectional Study.Food science & nutrition1 mentions
- 2026Modulation of the serotonergic system restores oxidative balance and gene expression in the brain and heart of rats with obesity induced by overnutrition.Frontiers in physiology1 mentions
- 2026The Effect of Liraglutide on the Hypolipidemic, Anti-Inflammatory, and Antioxidant Properties of Atorvastatin Mediated via the Nrf2/HO-1 Signaling Pathway: In Vivo and In Silico Validation.Pharmaceutics1 mentions
- 2026Impacts of Dietary Patterns and Screen Time on the Risk of Developing Type 2 Diabetes Mellitus Among Children in Saudi Arabia: A Cross-Sectional Study.Cureus1 mentions
- 2026The distinct musculoskeletal phenotypes of Type 1 and Type 2 diabetes: a sonographic characterization of enthesopathy burden.Advances in rheumatology (London, England)1 mentions
- 2026Triglyceride-glucose indices distinguish clinical from preclinical obesity in US adults: A cross-sectional study.Medicine1 mentions
- 2026Irisin-Driven AMPK-PGC-1α Activation Underlies the Renoprotective Effects of Swimming Exercise in Obesity-Induced Kidney Injury.Biomolecules1 mentions
- 2026Targeting Gut Microbiota by DPP-4 Inhibitors in Obesity: Mechanistic Insights and Therapeutic Implications.Current nutrition reports1 mentions
- 2026Childhood Obesity: Global Burden, Multifactorial Etiologies, Biological Mechanisms, and Emerging Interventions for Prevention and Management.Saudi medical journal1 mentions
- 2026Maternal CDKAL1 polygenic risk and offspring growth trajectories beyond gestational diabetes.Pediatric research1 mentions
- 2026Latent autoimmune diabetes in Saudi adults aged 30-55 years old seen at a tertiary hospital in Riyadh, Saudi Arabia.Journal of family medicine and primary care1 mentions
- 2026Genetic and Metabolic Basis of Increased Diabetes Mellitus Risk in Down Syndrome: A Narrative Review.Canadian journal of diabetes1 mentions
- 2026Epidemiological Trends and Burden of Adult Kidney Cancer in Saudi Arabia: A 42-Year Retrospective Analysis (1982-2023).Cancer reports (Hoboken, N.J.)1 mentions
- 2026Innovations in Pediatric Nursing: Emerging Technologies Including Virtual Reality, Telehealth, Artificial Intelligence, and Digital Mental Health-A Scoping Review.SAGE open nursing1 mentions
- 2026Microbiome and One Health in GCC countries: current status, research gaps, and future directions.Frontiers in microbiology1 mentions
- 2026Premature atherosclerotic cardiovascular disease in the MENA region: economic impact, barriers to care, and policy recommendations for an escalating crisis.Current opinion in lipidology1 mentions
- 2026Epoxy Clerodane Diterpene Attenuates the Differentiated Adipocyte Hypertrophy and Enhances Mitochondrial Metabolism.ChemistryOpen1 mentions
- 2026Chrononutrition and cardiometabolic health: circadian timing as a dimension of precision nutrition.Frontiers in nutrition1 mentions
- 2026Association between leptin gene polymorphisms and hematological metabolic parameters in obese Saudi adults.Frontiers in medicine1 mentions
- 2026Interplay between CARD9 genetic variants and fungal colonization patterns among patients with diabetes.Frontiers in fungal biology1 mentions
- 2026Diagnostic and prognostic biomarkers in PCOS: Navigating insulin resistance, systemic inflammation, and endometrial receptivity.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2026Probiotic Modulation of Gut Microbiota: Antioxidant Mechanisms and Clinical Benefits in Obesity and Type 2 Diabetes Management.Antioxidants (Basel, Switzerland)1 mentions
- 2026Association Between Metabolic Syndrome and Prostate Cancer: A Systematic Review.Cancers1 mentions
- 2026Vinpocetine Attenuates Hepatic Steatosis by Modulating Key Lipogenic and Lipid Transport Genes (PPAR- γ, SREBP, and FAT/CD36) in Experimental Non-Alcoholic Fatty Liver Disease.Journal of biochemical and molecular toxicology1 mentions
- 2026Nutritional characterization and postprandial glycemic response of low-calorie date snacks incorporating psyllium and oat fibers in healthy and type 2 diabetes.Frontiers in nutrition1 mentions
- 2026Weight loss with atogepant in the long-term treatment of migraine: An interim analysis of a safety endpoint from a phase 3, multicenter, open-label, 156-week extension study.Headache1 mentions
- 2026Obesity and Risk of Pediatric-Onset Multiple Sclerosis (POMS): a Systematic Review and Meta-Analysis.Maedica1 mentions
- 2026Genome-wide association studies of missing metabolite measures from two population-based studies.Genome biology1 mentions
- 2025Dietary pattern, physical activity and body composition of Children with and without Down Syndrome - A case control study.Journal of intellectual disabilities : JOID1 mentions
- 2025Bacterial metabolomics: current applications for human welfare and future aspects.Journal of Asian natural products research1 mentions
- 2025Natural Honey Proteins Prevent Diet-Induced Obesity and Metabolic Disorders in Rats.Journal of medicinal food1 mentions
- 2025Long-term all-cause mortality of metabolic-dysfunction associated steatotic liver disease based on body weight phenotypes following acute myocardial infarction: A retrospective cohort study.Diabetes, obesity & metabolism1 mentions
- 2025Metabolic Phenotype and Risk of Obesity-Related Cancers in the Women's Health Initiative.Cancer prevention research (Philadelphia, Pa.)1 mentions
- 2025Upregulation versus loss of function of NTRK2 in 44 affected individuals leads to 2 distinct neurodevelopmental disorders.Genetics in medicine : official journal of the American College of Medical Genetics1 mentions
- 2025Maternal epilepsy and pregnancy, delivery and neonatal outcomes: A population-based retrospective cohort study.Epilepsy & behavior : E&B1 mentions
- 2025Long-Term Remission Rate of Type 2 Diabetes Following Bariatric Surgery: A Retrospective Cohort Study in Adult Patients in Riyadh, Saudi Arabia.Cureus1 mentions
- 2025Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry.European heart journal1 mentions
- 2025Resveratrol Anti-inflammatory Effect against Palmitate-induced Cytotoxicity in Raw 264.7 Macrophages.Current medicinal chemistry1 mentions
- 2025Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies.Food science & nutrition1 mentions
- 2025Serum levels of Wnt5a in Egyptian women with obesity and their association with toll like receptor 2 Arg753Gln gene polymorphism in a pilot case control study of obesity as a state of metaflammation.Scientific reports1 mentions
- 2025Clinical Epidemiology and Phenotypic Characteristics of Hidradenitis Suppurativa Disease in the Central Region of Saudi Arabia: Findings from a Cross-Sectional.Clinical, cosmetic and investigational dermatology1 mentions
- 2025Frailty determinants in heart failure: Inflammatory markers, cognitive impairment and psychosocial interaction.ESC heart failure1 mentions
- 2025Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome-An Update.Medicina (Kaunas, Lithuania)1 mentions
- 2025A Clinicopathological Study of Surface Epithelial Tumors of the Ovary: A Retrospective Analysis at a Tertiary Care Center in Jeddah, Saudi Arabia.Cureus1 mentions
- 2025A Review on miRNAs in Enteric Bacteria-mediated Host Pathophysiology: Mechanisms and Implications.Journal of biochemical and molecular toxicology1 mentions
- 2025Harnessing Artificial Intelligence in Obesity Research and Management: A Comprehensive Review.Diagnostics (Basel, Switzerland)1 mentions
- 2025University Students' Sociodemographics, Physical Inactivity, and Inadequate and Poor-Quality Sleep Are Associated With Their Overweight/Obesity: Findings From a Case-Control Study in Bangladesh.Health science reports1 mentions
- 20253D facial imaging: a novel approach for metabolic abnormalities risk profiling.Science China. Life sciences1 mentions
- 2025Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link.Journal of the National Cancer Center1 mentions
- 2025(Z)-N-(3-([1,1'-biphenyl]-2-yl)-4-heptyl-4-hydroxythiazolidin-2-ylidene)-4-bromobenzamide as carbonic anhydrase inhibitor: exploration of its in vitro and in silico studies.BMC chemistry1 mentions
- 2025Unraveling the Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic Interventions.International journal of molecular sciences1 mentions
- 2025Comprehensive review of thrombophilia: pathophysiology, prevalence, risk factors, and molecular diagnosis.Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine1 mentions
- 2025Clinical characterization of blood pressure phenotypes: the BP phenotype score.Blood pressure1 mentions
- 2025Global Effect of Cardiovascular Risk Factors on Lifetime Estimates.The New England journal of medicine1 mentions
- 2025Cross-sectional analysis of eating disorder risk and risk correlates in candidates for bariatric surgery from the BariPredict cohort.Scientific reports1 mentions
- 2025Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults.Frontiers in nutrition1 mentions
- 2025Prevalence and impact of endocrinopathies on growth in pediatric down syndrome patients: A retrospective analysis.Saudi medical journal1 mentions
- 2025The REDOX balance in the prefrontal cortex is positively modulated by aerobic exercise and altered by overfeeding.Scientific reports1 mentions
- 2025Gut microbiota diversity in obese rats treated with intermittent fasting, probiotic-fermented camel milk with or without dates and their combinations.Scientific reports1 mentions
- 2025Exploring the efficacy of Benincasa hispida extract on obesity linked inflammatory bowel disease by integrating computational analysis and experimental validations.Scientific reports1 mentions
- 2025Environmental and Familial Risk Factors for Multiple Sclerosis: Insights from a Saudi Arabian Cohort.Medicina (Kaunas, Lithuania)1 mentions
- 2025Beyond the Gut: Unveiling Butyrate's Global Health Impact Through Gut Health and Dysbiosis-Related Conditions: A Narrative Review.Nutrients1 mentions
- 2025Canagliflozin: A Comprehensive Review of Advances in Preclinical Research.Drug research1 mentions
- 2025Obesity and its management in primary care setting.Journal of diabetes and its complications1 mentions
- 2025Long-term outcomes of congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a retrospective study from a tertiary care center in Saudi Arabia.Frontiers in endocrinology1 mentions
- 2025Role and Significance of MicroRNAs in the Relationship Between Obesity and Cancer.Balkan medical journal1 mentions
- 2025Clinical studies on anti-obesity medications in Arab countries.Saudi medical journal1 mentions
- 2025Glucagon-like peptide-1 receptor agonists: a review from a cardiovascular perspective.Frontiers in cardiovascular medicine1 mentions
- 2025Stearoyl-CoA desaturase 1 deficiency drives saturated lipid accumulation and increases liver and plasma acylcarnitines.Journal of lipid research1 mentions